A previously unreported <i>Dra</i>I polymorphism within the regulatory region of the bovine <i>growth hormone</i> gene and its association with growth traits in Korean Hanwoo cattle

Kim, N. K.; Yw, Seo; Kim, G. H.; Joh, J. H.; Kim, O. H.; Chung, E. R.; Lee, C. S.

doi:10.1111/j.1365-2052.2004.01100.x

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…The finding is not surprising for GH and NPY-3, which were reported to be polymorphic only in one or few breeds (Kim et al, 2004;Sherman et al, 2008), while it was unexpected for GDF8-3, for which polymorphism had been described in the Piemontese breed, though in a more limited sample (Vankan et al, 2010). It is also interesting to note that in the Piemontese GDF8-1 was monomorphic too, while variability was reported by Crisà et al (2003) in the same breed.…”

Section: Resultsmentioning

confidence: 72%

Comparison of Four Italian Beef Cattle Breeds by Means of Functional Genes

Lasagna

Ceccobelli

Lorenzo

et al. 2015

Italian Journal of Animal Science

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Piemontese, Chianina, Marchigiana and Romagnola are the main Italian beef breeds, and the quality of their products is largely recognised all over the world. Here, 18 single nucleotide polymorphisms (SNPs) in 12 candidate genes involved on meat traits were investigated on 1055 candidates for selection in order to analyse the within-and betweenbreed variability with a functional marker approach. Three SNPs (GDF8-3, GH and NPY-3) were monomorphic and most of the polymorphic SNPs showed an allele distribution quite similar in the four breeds. High variability at LEP-2, LEP-3 and LEPR markers was detected across breeds and the analysis of the relationship between genetic differentiation and heterozygosity indicated significant deviation from a neutral-equilibrium model for LEP-2. The highest pairwise fixation index values (0.1189 to 0.1877) were obtained for the comparisons of Piemontese with the other breeds, while the lowest value (0.0296) was observed in Chianina and Marchigiana. The Piemontese differentiation from the other breeds could be due to its geographical isolation and selection targets. The results for breed assignment follows the genetic differentiation, in fact, Piemontese had the highest percentage of correct assignment (87.6), while Marchigiana had the lowest (47.5). These findings suggest that functional markers can be more suitable than neutral markers in discriminating breeds similar in morphology if selection plays some role in their differentiation.

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Section: Resultsmentioning

confidence: 72%

Comparison of Four Italian Beef Cattle Breeds by Means of Functional Genes

Lasagna

Ceccobelli

Lorenzo

et al. 2015

Italian Journal of Animal Science

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“…The variations of GH, GHR and other genes in the growth hormone pathway could lead to serious abnormal growth such as dwarfism 25 26 27 and adiposity 28 , and the over-expression of growth hormone is the major cause for gigantism in human 29 . The associations between the variations of these genes and growth traits have also been identified in livestock 30 31 32 33 , poultry 34 and a few fishes 35 . It is generally accepted that the mutations of genes related to the growth hormone could cause significant differences of growth.…”

Section: Discussionmentioning

confidence: 97%

A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia

Liu

Sun

Xia

et al. 2014

Sci Rep

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Growth is an important trait in animal breeding. However, the genetic effects underpinning fish growth variability are still poorly understood. QTL mapping and analysis of candidate genes are effective methods to address this issue. We conducted a genome-wide QTL analysis for growth in tilapia. A total of 10, 7 and 8 significant QTLs were identified for body weight, total length and standard length at 140 dph, respectively. The majority of these QTLs were sex-specific. One major QTL for growth traits was identified in the sex-determining locus in LG1, explaining 71.7%, 67.2% and 64.9% of the phenotypic variation (PV) of body weight, total length and standard length, respectively. In addition, a candidate gene GHR2 in a QTL was significantly associated with body weight, explaining 13.1% of PV. Real-time qPCR revealed that different genotypes at the GHR2 locus influenced the IGF-1 expression level. The markers located in the major QTL for growth traits could be used in marker-assisted selection of tilapia. The associations between GHR2 variants and growth traits suggest that the GHR2 gene should be an important gene that explains the difference in growth among tilapia species.

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“…Mutations in the GHR gene alter GH functions by changing the protein's ability to bind to this receptor on target cells (Maskur and Arman 2014). Several reports documented the association between milk yield and composition in cattle and the polymorphism in ABCG2 (Mousavizadeh et al 2013;Ghombavani et al, 2016), GH (Ge et al, 2003;Kim et al, 2004;Mullen et al, 2010;Komisarek et al, 2011;Mullen et al, 2011), and GHR genes (Blott et al, 2003;Maj et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

El‐Nahas¹

2018

PVJ

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The aim of the present study was to evaluate the effect of polymorphisms in the ATP-binding cassette subfamily G member 2 (ABCG2), growth hormone (GH) and growth hormone receptor (GHR) genes on 305-day yields and milk traits in native Egyptian cattle (Baladi), Holstein Friesian cattle and hybrid cattle using DNA sequencing and Restriction Fragment Length Polymorphisms (RFLPs). A total of 148 cows were selected from the three animal populations. The ABCG2-HhaI-AA genotype was significantly associated with an increased milk lactose percentage and reduced milk yields in Baladi cows. The GH-MSP1-heterozygous genotype (GH) showed significant associations with SNF, protein and lactose percentages in the hybrid cows. Fewer TG repeats were found in the 5' untranslated region of GHR in Baladi cows, which could be used for marker-assisted selection to protect against the lower milk yields observed in this population. Additionally, GHR-MSP1-VL, can be associated with higher SNF, fat, protein and lactose percentages in hybrid cows, as well as lower milk yields in Baladi cows. We concluded that the three cattle populations have their own genetic identities in relation to genetic markers, which can be used for marker-assisted selection to improve milk traits in these three cattle populations.

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A previously unreported DraI polymorphism within the regulatory region of the bovine growth hormone gene and its association with growth traits in Korean Hanwoo cattle

Cited by 10 publications

References 7 publications

Comparison of Four Italian Beef Cattle Breeds by Means of Functional Genes

Comparison of Four Italian Beef Cattle Breeds by Means of Functional Genes

A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia

Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

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