A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

Boge, T; Remigy, M.; Vaudaine, Sarah; Tanguy, Jérôme; Bourdet‐Sicard, Raphaëlle; Werf, Sylvie van der

doi:10.1016/j.vaccine.2009.06.094

Cited by 206 publications

(173 citation statements)

References 23 publications

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“…13 This study benefitted from a high degree of similarity among the study groups, effectively controlling for a range of potential influences on responses to vaccination including age, 19 sex, prior influenza vaccination, 15,16 frailty, 20 chronic health conditions, obesity, 21 moderate exercise 22 and probiotic use. 23 Similarity of baseline antibody titers among the study groups avoided the need for adjustment of observed responses. 24 Baseline antibody titers to B/Brisbane were much higher in this study (e.g., GMT 157.4) than in recent studies in seniors by Chi et al 25 (GMT 10.8) and Falsey et al 6 (GMT 19.0).…”

Section: Discussionmentioning

confidence: 99%

Safety, immunogenicity, and tolerability of three influenza vaccines in older adults

Scheifele

McNeil

Ward

et al. 2013

Human Vaccines & Immunotherapeutics

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Section: Discussionmentioning

confidence: 99%

Safety, immunogenicity, and tolerability of three influenza vaccines in older adults

Scheifele

McNeil

Ward

et al. 2013

Human Vaccines & Immunotherapeutics

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“…Pilot study: probiotic (n 44) or placebo (n 42) consumed for 7 weeks Confirmatory study: probiotic (n 113) or placebo (n 109) consumed for 13 weeks. Vaccination after 4 weeks Trend for higher virus-specific antibody titres in probiotic v. control group Significantly greater seroconversion rate for B strain in main study at 3, 6 and 9 weeks post-vaccination in probiotic v. placebo group (P = 0·02) (77) Lactobacillus fermentum Healthy adults given probiotic (n 25) or placebo (n 25) for 4 weeks; vaccination on day 14…”

Section: Probiotics and The Immune Response To Influenza Vaccinationmentioning

confidence: 89%

“…Four out of eight of the studies investigating the impact of probiotics on responses to influenza vaccination were conducted in healthy adults (72)(73)(74)(75) , while the remaining four were conducted in elderly subjects (76)(77)(78)(79) ; three of these were conducted in institutionalised individuals (77)(78)(79) (Table 1). The largest of the trials conducted in elderly subjects (n 362 and 375 on probiotic and placebo, respectively) demonstrated no effect of L. casei Shirota on respiratory infections, seroprotection, seroconversion or mean antibody titres (79) .…”

Section: Probiotics and The Immune Response To Influenza Vaccinationmentioning

confidence: 99%

Ageing, immunity and influenza: a role for probiotics?

Yaqoob

2013

Proc. Nutr. Soc.

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Influenza is a major cause of death in the over 65s. Increased susceptibility to infection and reduced response to vaccination are due to immunosenscence in combination with medical history and lifestyle factors. Age-related alterations in the composition of the gut microbiota have a direct impact on the immune system and it is proposed that modulation of the gut microbiota using pre- and probiotics could offer an opportunity to improve immune responses to infections and vaccination in older people. There is growing evidence that probiotics have immunomodulatory properties, which to some extent are strain-dependent, and are strongly influenced by ageing. Randomised controlled trials suggest that probiotics may reduce the incidence and/or severity of respiratory infections, although there is limited data on older people. A small number of studies have examined the potential adjuvant effects of selected probiotics for vaccination against influenza; however, the data is inconsistent, particularly in older people. This review describes the impact of age-related changes in the gut on the immune response to respiratory infections and evaluates whether restoration of gut microbial homoeostasis by probiotics offers an opportunity to modulate the outcome of respiratory infections and vaccination against influenza in older people. Although there is promising evidence for effects of probiotics on human health, there is a lack of consistent data, perhaps partly due to strain-specific differences and an influence of the age of the host. Further research is critical in evaluating the potential use of probiotics in respiratory infections and vaccination in the ageing population.

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“…Some studies have shown improved response to vaccination with a dietary intervention, while others have not. Studies involving prebiotics and response to vaccination were included in the review by (20) , while studies of probiotics were reviewed by Lomax &Calder (2009) (21) and by Maidens et al (2013) (22) (23) reported two controlled studies of oral Lactobacillus casei DN-114 001 administration for 7 weeks (study 1) and 13 weeks (study 2) in elderly subjects (>70 years of age; mean age about 84 years) who received the seasonal influenza vaccine after 4 weeks. Study 1 used the 2005/2006 seasonal influenza vaccine and identified 40 to 50 % seroprotection and 20-50 % seroconversion (depending upon viral strain) in the control group 3 weeks post-vaccination, in keeping with the relatively poor response to vaccination in the elderly.…”

Section: Refining the Criteria And Developing A New Evaluation Templatementioning

confidence: 99%

Improving selection of markers in nutrition research: evaluation of the criteria proposed by the ILSI Europe Marker Validation Initiative

et al. 2017

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The conduct of high-quality nutrition research requires the selection of appropriate markers as outcomes, for example as indicators of food or nutrient intake, nutritional status, health status or disease risk. Such selection requires detailed knowledge of the markers, and consideration of the factors that may influence their measurement, other than the effects of nutritional change. A framework to guide selection of markers within nutrition research studies would be a valuable tool for researchers. A multidisciplinary Expert Group set out to test criteria designed to aid the evaluation of candidate markers for their usefulness in nutrition research and subsequently to develop a scoring system for markers. The proposed criteria were tested using thirteen markers selected from a broad range of nutrition research fields. The result of this testing was a modified list of criteria and a template for evaluating a potential marker against the criteria. Subsequently, a semi-quantitative system for scoring a marker and an associated template were developed. This system will enable the evaluation and comparison of different candidate markers within the same field of nutrition research in order to identify their relative usefulness. The ranking criteria of proven, strong, medium or low are likely to vary according to research setting, research field and the type of tool used to assess the marker and therefore the considerations for scoring need to be determined in a setting-, field-and tool-specific manner. A database of such markers, their interpretation and range of possible values would be valuable to nutrition researchers.

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A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

Cited by 206 publications

References 23 publications

Safety, immunogenicity, and tolerability of three influenza vaccines in older adults

Safety, immunogenicity, and tolerability of three influenza vaccines in older adults

Ageing, immunity and influenza: a role for probiotics?

Improving selection of markers in nutrition research: evaluation of the criteria proposed by the ILSI Europe Marker Validation Initiative

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