A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Gallo, J. C.; Schneider, Johann; Wet, Johann de; Moxley, Karis; Jordaan, H.F.; Visser, Willem I; Tod, Bianca

doi:10.1155/2022/8443867

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Epidermal inclusion cyst was the commonest benign lesion in accordance with several other studies 9,13,18 . Basal cell carcinoma was the most frequently encountered malignant tumor (63/68) 92.6% comparable to studies by Garrubba C, Gallo JC et al and Al-Dawsari NA 19,20,21 . Pemphigus vulgaris was the most common bullous lesion followed by bullous pemphigoid comparable with various other studies 5,22 .…”

Section: Discussionsupporting

confidence: 85%

Histopathological Review of Skin Diseases: A Three Years Survey of 510 Skin Biopsies in Multan

Ali¹,

Ali²,

Kanwar³

et al. 2023

PJMHS

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Introduction: Skin ailments share a major disease burden worldwide (1, 2).They are considerably frequent in underdeveloped nations and encompass simple ailments like inflammation and pimples to certain grave diseases like skin melanomas (3). However, the type and prevalence of skin disorders differ from area to area on account of dissimilar habitat (4, 5). Skin disorders influence human lives in various ways and many a times the dermal epidermal conditions point some internal ongoing serious disease (6). A vast majority of skin diseases are treated on the basis of clinical diagnosis without confirmation through biopsy. Microscopic examination is mandatory for verification and precise diagnosis and to direct the clinician to opt suitable treatment (7). Considering their importance, the research work being done on the prevalence of specific disorders in particular regions in our country appears deficient especially considering the clinicopathological consonance. The current research was outlined to acumen the skin diseases related burden in our institute. Aim & Objective: The aim of this research is to evaluate the histopathological diversity of skin diseases and their prevalence in Multan region along with the clinic-pathological consonance. Study Design: Retrospective cross sectional study Place and Duration: Histopathology and dermatology departments of Bakhtawar Amin Medical & Dental College and Trust Hospital Multan, from January 2020 to December 2022. Material and Methods: Histopathological reports of all skin biopsies were sorted. The required data like age, gender, clinical presentation, site of the lesion, dermatologist’s findings, and their clinical provisional impression with differential diagnoses were documented along with the histopathological microscopic opinion. The particulars were gathered from clinical files, histopathological demand forms and documented reports. Results: A sum of 510 skin biopsies was received in histopathology section. Out of these, 280 (54.9%) were females and remaining 230 (45.1%) were males. The mean age was 34.70 years (ranging from 2 to 84 years). Most of them were between ages 16-30 years. Majority of the lesions were benign non cancerous and related to skin appendages. Epidermal inclusion cyst appeared to be the most prevalent. Out of 510 biopsies, 68 (13.3%) turned out to be malignant neoplasms. Conclusion: A vast majority of skin diseases are treated only on the basis of clinical diagnosis. The present study revealed that the histopathological opinion was consistent with the clinical judgment in 63 % of the cases, unveiling the significance of histopathological examination that is must for saving time and expenses of the patients. It also helps in reduction of the morbidity related to various skin disorders Keywords: Histopathology, dermatology, skin disorders, skin cancers, epidermal inclusion cyst

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Section: Discussionsupporting

confidence: 85%

Histopathological Review of Skin Diseases: A Three Years Survey of 510 Skin Biopsies in Multan

Ali¹,

Ali²,

Kanwar³

et al. 2023

PJMHS

View full text Add to dashboard Cite

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Clinical Characteristics of Local Recurrent Basal Cell Carcinoma After Surgical Excision: A Retrospective Study of the Patients From a Tertiary Clinical Center

Bal Avci,

Koku Aksu,

Ilhan Erdil

et al. 2024

Cureus

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Background: Basal cell carcinoma (BCC) is the most frequent form of skin cancer. The etiology of recurrent BCC is multifactorial, and the recurrence rate is variable. Objective: The aim of the study was to identify the risk factors of local recurrence after surgical excision in primary BCC. Materials and methods: In our study, 934 patients histopathological diagnosed with BCCs between January 2017 and June 2022 were evaluated retrospectively. Among these, patients who were regularly followed up for at least three years were included in the study. Patients who underwent non-excision treatment were excluded. All the patients who had pathologically confirmed, surgically excised BCCs with safety margins and those with a clinicopathological diagnosis of recurrent BCCs. Demographic and clinical features of 78 patients with non-recurrent primary BCC and 55 patients with local recurrent BCC were compared. Results: The mean age was 69.7±11.7 years. The gender distribution was M/F:1.3. The time from diagnosis to total surgical excision was 2.3±1.4 months, and the time of recurrence was 27.5±23.3 months. The age of the patients, the time from diagnosis to total excision, the lesion size > 2 cm, and the presence of risk factors (such as radiotherapy, malignancy, and immunosuppression) were higher in the recurrent group than in the non-recurrent group (p < 0.05). Location (high/medium/low-risk area) and the presence of multiple lesions did not differ significantly between the recurrent and non-recurrent groups. Conclusion: In patients with BCC, recurrence is often detected in the first three years after diagnosis. Our study determined age, lesion size, accompanying risk factors, and the length of time until total excision as risk factors for recurrence in BCC patients. The histological subtype and lesion localization did not differ between the group with and without recurrence.

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A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Cited by 2 publications

References 30 publications

Histopathological Review of Skin Diseases: A Three Years Survey of 510 Skin Biopsies in Multan

Histopathological Review of Skin Diseases: A Three Years Survey of 510 Skin Biopsies in Multan

Clinical Characteristics of Local Recurrent Basal Cell Carcinoma After Surgical Excision: A Retrospective Study of the Patients From a Tertiary Clinical Center

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