This article addresses the difficulty of introducing and establishing multidisciplinarity in environmental research within and among the South-Mediterranean environmental research national communities. Moreover, this work attends to assess the internal and external structural factors treating such complex issues in rural, urban, and peri-urban contexts as well as the connections and dependencies of these factors. Throughout a series of programs, projects, and actions that involved scientists and scholars from Algeria, France, Lebanon, Morocco, and Tunisia, some common patterns can be observed despite notable differences in environmental and political contexts. Thus, the main common issues involve funding matters (budget reductions and less versatility), administrative and social hierarchy, relatively small connections with public services and community representatives, and finally the reluctance shown by many researchers to make data available for the community. Nevertheless, the fact that national and international (Arabic and French speaking sphere) researcher's communities have progressively built mutual knowledge thanks to different collaborations is a major achievement, sustaining multidisciplinarity in environmental research. Indeed, this allowed the elaboration of sustainability metrics, demarches, and procedures for assessing environmentally and socioeconomically complex issues.