A Prognostic System Applicable to Patients with Resectable Liver Metastasis from Colorectal Carcinoma Staged by Positron Emission Tomography with [18F]Fluoro-2-Deoxy-D-Glucose: Role of Primary Tumor Variables

Tan, Marcus; Castaldo, Eric T.; Gao, Feng; Chari, Ravi S.; Linehan, David C.; Wright, J. Kelly; Hawkins, William G.; Siegel, Barry A.; Delbeke, Dominique; Pinson, C. Wright; Strasberg, Steven M.

doi:10.1016/j.jamcollsurg.2007.12.023

Cited by 36 publications

(37 citation statements)

References 47 publications

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“…11,20,33,35,37,39,41,[43][44][45]47 Poor differentiation of primary tumor was considered a negative prognostic variable in only three studies 20,38,45 while in four other studies 34,35,39,44 it was not significantly associated with outcome.…”

Section: Prognostic Factorsmentioning

confidence: 94%

“…Only four studies 38,41,45,48 did not present it as a negative prognostic factor of survival after resection of CRLM.…”

Section: Prognostic Factorsmentioning

confidence: 96%

“…11,20,32,33,[35][36][37]39,42,[44][45][46] Nevertheless, six studies 34,38,40,41,47,48 concluded that regional lymph node metastases of primary tumor was not a significant prognostic factor for survival. This fact was supported by other studies not included in the analysis.…”

Section: Prognostic Factorsmentioning

confidence: 99%

“…11,43,48 Nine studies concluded that preoperative elevation of CEA is not significant as a prognostic factor after resection of CRLM. 33,[35][36][37]40,41,45 Maximum size of hepatic metastases was indicated as a prognostic factor in eight studies 11,20,32,33,34,37,41,46 and was considered without importance in 8 other studies. 35,36,[38][39][40][42][43][44][45]47,48 Extrahepatic disease (EHD) was considered a poor prognostic factor in seven of the nine prognostic scores that evaluated this parameter.…”

Section: Prognostic Factorsmentioning

confidence: 99%

“…33,[35][36][37]40,41,45 Maximum size of hepatic metastases was indicated as a prognostic factor in eight studies 11,20,32,33,34,37,41,46 and was considered without importance in 8 other studies. 35,36,[38][39][40][42][43][44][45]47,48 Extrahepatic disease (EHD) was considered a poor prognostic factor in seven of the nine prognostic scores that evaluated this parameter. 11,20,34,37,[46][47][48] In the majority of the analyzed studies patients with EHD were excluded from the analysis as many authors consider EHD a negative prognostic factor being considered as a contraindication for surgery of liver metastases in many institutions.…”

Section: Prognostic Factorsmentioning

confidence: 99%

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Prognostic Factors after Liver Resection for Colorectal Liver Metastasis

et al. 2015

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Introduction: Surgery is the only potentially curative treatment for patients with colorectal liver metastases, resulting in 5-year survival rates of 36-58%. Although many studies have been performed to determine prognostic factors for tumor recurrence and survival after resection of colorectal liver metastases, there are few prognostic scoring systems stratifying patients undergoing surgery for colorectal liver metastases into risk group models. Objectives: To identify, evaluate and compare the existing prognostic scores for survival after surgery for resection of colorectal liver metastases. Material and Methods:Electronic search in PubMed, Cochrane and Embase from 1990 to 2013 using the terms 'hepatic resection', 'colorectal cancer', 'liver metastasis', 'hepatectomy', 'prognostic', and 'score'. Only studies proposing a prognostic model or risk stratification based on clinical and/or pathological variables were included. Results: From 1996 to June 2013, 19 scoring systems were identified, including one nomogram. Thirty prognostic factors were identified although none of the factors was common to all prognostic models. The 4 factors most often included were: number of liver metastases, regional lymph node metastization of primary tumor, preoperative CEA level and maximum size of metastases. The median study sample size was 305 patients (81-1 568 patients) and median follow-up was 33 months (16-54 months). All studies were retrospective and used the Cox proportional hazards model for multi-variable analysis. Conclusion: Several factors have been constantly reported as having prognostic value after liver resection of colorectal liver metastases, although there is no consensus on the ideal scoring system.

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Section: Prognostic Factorsmentioning

confidence: 94%

“…Only four studies 38,41,45,48 did not present it as a negative prognostic factor of survival after resection of CRLM.…”

Section: Prognostic Factorsmentioning

confidence: 96%

Section: Prognostic Factorsmentioning

confidence: 99%

Section: Prognostic Factorsmentioning

confidence: 99%

Section: Prognostic Factorsmentioning

confidence: 99%

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Prognostic Factors after Liver Resection for Colorectal Liver Metastasis

et al. 2015

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Role of FDG‐PET staging in selecting the optimum patient for hepatic resection of metastatic colorectal cancer

Strasberg

Dehdashti

2010

Journal of Surgical Oncology

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Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes

Mahar

Compton

Halabi

et al. 2017

Journal of Surgical Oncology

116

104

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Integrating diverse types of prognostic information into accurate, individualized estimates of outcome in colorectal cancer is challenging. Significant heterogeneity in colorectal cancer prognostication tool quality exists. Methodology is incompletely or inadequately reported. Evaluations of the internal or external validity of the prognostic model are rarely performed. Prognostication tools are important devices for patient management, but tool reliability is compromised by poor quality. Guidance for future development of prognostication tools in colorectal cancer is needed.

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A Prognostic System Applicable to Patients with Resectable Liver Metastasis from Colorectal Carcinoma Staged by Positron Emission Tomography with [18F]Fluoro-2-Deoxy-D-Glucose: Role of Primary Tumor Variables

Cited by 36 publications

References 47 publications

Prognostic Factors after Liver Resection for Colorectal Liver Metastasis

Prognostic Factors after Liver Resection for Colorectal Liver Metastasis

Role of FDG‐PET staging in selecting the optimum patient for hepatic resection of metastatic colorectal cancer

Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes

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