Role of FDG‐PET staging in selecting the optimum patient for hepatic resection of metastatic colorectal cancer

Strasberg, Steven M.; Dehdashti, Farrokh

doi:10.1002/jso.21729

Cited by 15 publications

(12 citation statements)

References 42 publications

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“…In some patients, the 30 min extra scanner time necessary for the RGL-PET and PL-PET may change clinical management of potentially resectable colorectal liver metastases by either preventing futile laparotomies or by leading to a change in surgical strategy. Moreover, the study confirms the importance of performing a 18F-FDG PET before surgical resection of colorectal liver metastases to rule out extrahepatic malignancy and to confirm the CT findings of liver lesions suspicious of malignancy (6,7,14).…”

Section: Discussionsupporting

confidence: 71%

“…Accurate diagnostic imaging in the preoperative assessment of patients with potentially resectable colorectal liver metastases is essential in order to identify candidates for curative liver surgery (6,7). Current guidelines (October 2013) from the National Comprehensive Cancer Network (NCCN) recommend a staging 2-deoxy-2-(18F)fluoro-D-Glucose positron emission tomography (18F-FDG PET) examination for patients with potentially surgically curable metastatic colorectal cancer (8).…”

Section: Introductionmentioning

confidence: 99%

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Respiratory gated and prolonged acquisition 18F-FDG PET improve preoperative assessment of colorectal liver metastases

et al. 2015

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Respiratory gated and prolonged acquisition 18F-FDG PET improve preoperative assessment of colorectal liver metastases

et al. 2015

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“…The specificity of the radiolabel is important for accurately marking a target tissue for imaging. In particular, PET imaging with 2′-[ 18 F]fluorodeoxyglucose ( 18 FDG PET) has become a useful tool in the evaluation of tumor lesions, particularly for pancreatic cancer, and the discovery of distant metastases [5], [6], [7], [8]. 18 FDG is a glucose analog that is taken up avidly by rapidly growing malignant masses, but not all hot spots are cancerous.…”

Section: Introductionmentioning

confidence: 99%

Consistent Surgeon Evaluations of Three-Dimensional Rendering of PET/CT Scans of the Abdomen of a Patient with a Ductal Pancreatic Mass

Wampole

Kairys²,

Mitchell³

et al. 2013

PLoS ONE

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Two-dimensional (2D) positron emission tomography (PET) and computed tomography (CT) are used for diagnosis and evaluation of cancer patients, requiring surgeons to look through multiple planar images to comprehend the tumor and surrounding tissues. We hypothesized that experienced surgeons would consistently evaluate three-dimensional (3D) presentation of CT images overlaid with PET images when preparing for a procedure. We recruited six Jefferson surgeons to evaluate the accuracy, usefulness, and applicability of 3D renderings of the organs surrounding a malignant pancreas prior to surgery. PET/CT and contrast-enhanced CT abdominal scans of a patient with a ductal pancreatic mass were segmented into 3D surface renderings, followed by co-registration. Version A used only the PET/CT image, while version B used the contrast-enhanced CT scans co-registered with the PET images. The six surgeons answered 15 questions covering a) the ease of use and accuracy of models, b) how these models, with/without PET, changed their understanding of the tumor, and c) what are the best applications of the 3D visualization, on a scale of 1 to 5. The six evaluations revealed a statistically significant improvement from version A (score 3.6±0.5) to version B (score 4.4±0.4). A paired-samples t-test yielded t(14) = −8.964, p<0.001. Across the surgeon cohort, contrast-enhanced CT fused with PET provided a more lifelike presentation than standard CT, increasing the usefulness of the presentation. The experienced surgeons consistently reported positive reactions to 3D surface renderings of fused PET and contrast-enhanced CT scans of a pancreatic cancer and surrounding organs. Thus, the 3D presentation could be a useful preparative tool for surgeons prior to making the first incision. This result supports proceeding to a larger surgeon cohort, viewing prospective 3D images from multiple types of cancer.

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“…18 F]fluorodeoxyglucose ( 18 FDG PET) has become a useful tool in the evaluation of tumor lesions, particularly for pancreatic cancer, and the discovery of distant metastases [40][41][42][43]. 18 FDG is a glucose analog that is taken up aggressively by rapidly growing malignant masses, but not all hot spots are cancerous.…”

Section: Discussionmentioning

confidence: 99%

Three Dimensional Projection Environment for Molecular Design and Surgical Simulation

Wickstrom

Chen²,

Devadhas³

et al. 2011

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REPORT DOCUMENTATION PAGEForm Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) 29- 07-2009 -28-07-2011 REPORT DATE (DD-MM-YYYY) 28-08-2011 REPORT TYPE Final DATES COVERED SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)Medical Research and Materiel USAMRMC Materiel Command TATRC Telemedicine & Advanced Fort Detrick SPONSOR/MONITOR'S REPORTTechnology Research Center Maryland 21702-5012 NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release; distribution unlimited SUPPLEMENTARY NOTES ABSTRACTWe hypothesized in Aim 1 that docking of three-dimensional (3D) projections of potential target binding agents with 3D projections of macromolecular disease targets visualized on a computer with touch and feel feedback will enable identification of optimal agent designs, and culling of suboptimal agent designs, prior to synthesis. We found that direct measurements of cellular uptake of two different EGF fragments, EGF20-31 and EGF32-48, agreed with the computer predictions of no uptake by EGF20-31, and significant uptake by EGF32-48. This observation is consistent with our first hypothesis. We hypothesized in Aim 2 that 3D FDG PET images of patients superimposed on 3D anatomical images of patients visualized on a large computer display would enable improved preoperative planning, because the FDG PET images revealed specific sites of active disease. We found that a set of 6 experienced surgeons found that the final 3D version was accurate, useful, and worth applying in practice. This observation is consistent with our second hypothesis. SUBJECT TERMScancer, computerized tomography, haptic, hybridization, imaging, molecular dynamics, nuclear medicine, oncogene, pancreatic, positron emission tomography, receptors, surgery, volumetric A. INTRODUCTIONWe hypothesized that our fusion of genetic, visual, and tactile information would improve surgeons' understanding of the extent of disease and will ultimately permit surgeons to better plan operations and to prepare for the actual pathology found. We proposed to combine current medical imaging technologies with genetic imaging to leverage our ability to pr...

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Role of FDG‐PET staging in selecting the optimum patient for hepatic resection of metastatic colorectal cancer

Cited by 15 publications

References 42 publications

Respiratory gated and prolonged acquisition 18F-FDG PET improve preoperative assessment of colorectal liver metastases

Respiratory gated and prolonged acquisition 18F-FDG PET improve preoperative assessment of colorectal liver metastases

Consistent Surgeon Evaluations of Three-Dimensional Rendering of PET/CT Scans of the Abdomen of a Patient with a Ductal Pancreatic Mass

Three Dimensional Projection Environment for Molecular Design and Surgical Simulation

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