A promising approach to optimizing the healing of postoperative infected wounds

Миронов, М.; Блинова, Е. В.; Степаненко, И. С.; Блинов, Д. С.; Abrosimov, A. V.; Kilmyashkina, M.F.; Dydykin, S.S.; Pakhomov, D. A.; Nelipa, M. V.; Чудайкин, А Н

doi:10.17116/operhirurg2018204123

Cited by 3 publications

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“…Лечение гнойно-воспалительных процессов мягких тканей остаётся и на сегодняшний день областью хирургии, которой уделяется недостаточно внимания со стороны специалистов как стационарного, так и амбулаторного звена, с множеством нерешённых проблем, приобретая новые оттенки, которые необходимо учитывать при отработке лечебной программы для каждого конкретного больного [1,2]. В настоящее время методология лечения гнойных процессов базируется, прежде всего, на хирургическом пособии как основном, и этот аспект не подвергается обсуждению ввиду его объективности и доказательности, подтверждённых многолетней клинической практикой [3].…”

Section: обоснованиеunclassified

The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon

Цеймах

Zinchenko

2021

Acta biomedica scientifica

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Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic processes are the emerging microcirculation disorders due to the formation of micro-clots. An important point that aggravates the course of the disease is the development of thrombohemorrhagic syndrome. As a result, even with a variety of antibacterial drugs and the ыavailability of new treatment methods, it is often not possible to achieve positive results in the treatment of this heavy contingent of patients.Aim: to improve the effectiveness of complex therapy of patients with extensive soft tissue phlegmon by relieving thrombohemorrhagic syndrome.Materials and methods. Cryoplasma-anti-enzyme therapy in the composition of complex treatment was received by 59 (48.8 %) patients of the main group, 62 (51.2 %) patients of the comparison group received only the generally accepted treatment. In each group, there are three variants of the course of the disease – moderate, severe and septic.Results. The analysis of the clinical course of the disease showed that in patients of the first group, wounds were cleared of necrotic masses and purulent discharge with filling them with healthy granulation tissue 5.3 days faster than in the second group (p˂0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The proportion of thrombotic and thromboembolic causes of death in the first group (14.3 %) was lower than in the second (17.7 %) (p˂ 0.05).Conclusion. The use of cryoplasma-anti-enzyme therapy as part of complex treatment contributed to the effective relief of thrombohemorrhagic syndrome, the elimination of microcirculatory disorders, which allowed performing plastic closure of a wound defect 1.6 times faster, prevented the progression of multiple organ failure, and contributed to a reduction in mortality.

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Section: обоснованиеunclassified

The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon

Цеймах

Zinchenko

2021

Acta biomedica scientifica

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Evidence-based aspects of stimulating uncomplicated wound healing with local use of acexamic acid silver salt

Pakhomov¹,

Блинова²,

Shimanovsky³

et al. 2020

Oper. khir.

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Comparative analysis of the healing dynamics in gunshot versus domestic purulent-infected wounds

Dunaevskaya,

Kosik

2024

jour

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Aim. To conduct a comparative analysis of the dynamics of healing of gunshot and domestic wounds in the purulent-infected stage, depending on the wound coating used.Methods. The study examined the treatment outcomes of 30 patients with gunshot and household purulent-infected soft tissue wounds, treated during a special operation in the Donetsk region of Donbass. Among these patients, those with gunshot wounds were military personnel involved in active combat. The gender distribution was 7 women (23 %) and 23 men (77 %), with a mean age of 42.5 years [range: 33.59 to 75 years]. The average Body Mass Index (BMI) of the patients was 27 kg/ m² [range: 25.35 to 28.15 kg/m²].Results. When comparing the patient groups, notable differences in wound healing rates were observed. The group with the highest healing rate showed significant progress, with wounds healing by 80.7 % by day 15 and 95.8 % by day 30. Another group, which underwent a similar treatment method, also demonstrated a high healing rate, albeit slightly lower: by day 15, wounds had healed by 71.6 % (3.1 % lower than the first group), and by day 30, the healing rate was 93.7 % (2.1 % lower). The groups with the lowest healing rates showed significantly slower progress, with healing rates of 52 % and 47.9 % on day 15, and 87 % and 81.5 % on day 30, respectively

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A promising approach to optimizing the healing of postoperative infected wounds

Cited by 3 publications

References 0 publications

The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon

The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon

Evidence-based aspects of stimulating uncomplicated wound healing with local use of acexamic acid silver salt

Comparative analysis of the healing dynamics in gunshot versus domestic purulent-infected wounds

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