A promising marker in early diagnosis of septic acute kidney injury of critically ill patients: urine insulin like growth factor binding protein-7

Aydoğdu, Müge; Boyacı, Nazlıhan; Yüksel, Seher; Gürsel, Gül; Sivri, Ayşe Banu Çaycı

doi:10.1080/00365513.2016.1187765

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…In congruence with our findings, A prospective multicentre observational study of 94 babies, (22) detected that Patients with AKI had substantially increased urine IGFBP-7*TIMP-2 levels. Other researchers (23) reported that IGFBP-7*TIMP-2 may reliably assess AKI development in neonates after cardiac operation. IGFBP-7*TIMP-2 usefulness in high-risk patients having major noncardiac surgery has also been studied.…”

Section: Discussionmentioning

confidence: 99%

Role of urinary Tissue inhibitor of metalloproteinase- 2 and Insuin like growth factor binding protein-7 in detection of acute kidney injury in critically ill children in pediatric intensive care unit

A. Sobeih,

S. Alsayed,

M. Ismail

et al. 2023

Benha Medical Journal

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Background: Acute kidney injury (AKI) is more prevalent in critically sick paediatric patients owing to variables like mechanical ventilation, severe infection and nephrotoxic medications. This study aimed to assess urinary TIMP-2 * IGFBP-7 role as an earlier predictor of AKI in critically ill children. Methods: This is case control study included pediatric patients admitted to PICU and at risk for AKI (Group I) and age-and sex-matching control group (Group II) which was split into 2 subgroups: Group II A that included children admitted to PICU without risk of AKI and Group II B as a control group that included healthy children not admitted to PICU. Children were exposed to a comprehensive history taking, clinical examination, and laboratory examinations. Two urine sample 48 hour apart for urinary tissue inhibitor of metalloproteinase-2 (TIMP-2), insulin-like growth factor binding protein-7 (IGFBP-7). Results: Cases with risk of AKI showed significantly higher TIMP2 and IGFBP7*TIMP2 those were the substantial AKI predictors, whereas no substantial change was seen among the groups in IGFBP7 levels. The described markers showed no significant differences according to the AKI etiological factors, long term outcome, AKI 30-day mortality or ICU stay length (p>0.05). Conclusions: The levels of IGFBP-7*TIMP-2 marker in the critically ill pediatric population could be a predictor of AKI risk. The studied markers did not show significant difference according to the mortality. Moreover, they did not show significant correlation with ICU stay length.

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Section: Discussionmentioning

confidence: 99%

Role of urinary Tissue inhibitor of metalloproteinase- 2 and Insuin like growth factor binding protein-7 in detection of acute kidney injury in critically ill children in pediatric intensive care unit

A. Sobeih,

S. Alsayed,

M. Ismail

et al. 2023

Benha Medical Journal

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“…[ 19 ], demonstrated that urinary [IGFBP-7]*[TIMP-2] was significantly higher in patients with AKI. It can effectively predict the occurrence of AKI following cardiac surgery in infants [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary NGAL, IGFBP-7, and TIMP-2: novel biomarkers to predict contrast medium-induced acute kidney injury in children

Sun

Kang

et al. 2022

Renal Failure

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Background Serum creatinine (SCr) is unreliable in detecting acute changes in kidney function. Early recognition of contrast-induced acute kidney injury (CI-AKI) can provide better opportunities for preventive interventions. Therefore, the purpose of this study is to examine the value of the combined detection of urinary neutrophil gelatinase-associated lipocalin (NGAL), insulin-like growth factor binding protein-7 (IGFBP-7), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the early diagnosis of children with CI-AKI. Methods A prospective, single-center clinical trial was performed and included 172 children aged 0–18 years. The dynamic changes of urinary NGAL, IGFBP-7, and TIMP-2 levels in children with intravascular injection of contrast medium were investigated to determine whether they can diagnose CI-AKI early. Results CI-AKI occurred in 20 of 137 enrolled patients, and the incidence was 14.59%. In the CI-AKI group, urinary levels of NGAL, IGFBP-7, TIMP-2, and [IGFBP-7]*[TIMP-2] were significantly increased 2 h after angiography and remained at high levels at 6 h. Using a cutoff value of 36.274 ng/mL, the specificity was 70.0%, and the sensitivity was 68.4% for the prediction of CI-AKI, which was excellent for urinary NGAL. When both urinary IGFBP-7 and TIMP-2 were used together, urinary [IGFBP-7]*[TIMP-2] at 0.417(ng/mL) 2 /1000 was regarded as the cutoff value. The specificity was 80.0%, and the sensitivity was 81.2%. Conclusions NGAL, IGFBP-7, and TIMP-2 concentrations in the urine of children after receiving injections of contrast medium increased faster than SCr and had good clinical value for the early diagnosis of CI-AKI in children. The combination of IGFBP-7 and TIMP-2 was better than either analyte alone.

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A promising marker in early diagnosis of septic acute kidney injury of critically ill patients: urine insulin like growth factor binding protein-7

Abstract: Admission urine IGFBP7 levels and following its course in ICUs can be used as a promising new biomarker for the early diagnosis of septic AKI development without being affected by sepsis itself.

Cited by 2 publications

References 40 publications

Role of urinary Tissue inhibitor of metalloproteinase- 2 and Insuin like growth factor binding protein-7 in detection of acute kidney injury in critically ill children in pediatric intensive care unit

Role of urinary Tissue inhibitor of metalloproteinase- 2 and Insuin like growth factor binding protein-7 in detection of acute kidney injury in critically ill children in pediatric intensive care unit

Urinary NGAL, IGFBP-7, and TIMP-2: novel biomarkers to predict contrast medium-induced acute kidney injury in children

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