With the deepened exploration and development of petroleum, pre-stack inversion can predict reservoir and petroleum distribution by extracting elastic parameters by virtue of the gathers. Because of the abundant information, pre-stack inversion has gradually become a focus of research. Existing studies indicate that pre-stack amplitude variation with angle simultaneous inversion has a favourable application effect in conventional shallow sandstone gas reservoirs, but has poor impact in deeply hidden-type reservoirs. For improved the precision of description and prediction of hidden-type reservoirs, the Shahejie Formation in the Gangbei District of the Gangzhong Oil Field was used as an example, and a method of predicting complicated structure-lithology reservoir based on improved Fatti reflection coefficient approximation formula was proposed in this study. Based on petrophysical analysis and coordinate transformation theory, with elastic parameters which were obtained by the new technology, the indicative factors of reservoir sensitivity were established, resulting in forming a series of accurate reservoir prediction methods. Results show that the improved inversion method can accurately describe sand bodies in a complicated structure-lithology reservoir. Indicative factors of reservoir sensitivity show favourable linear correlation with sand bodies and it can indicate reservoir distribution more effectively than the conventional method. Prediction results are in agreement with actual drilling results. The study provides a theoretical reference for identifying complicated structure-lithology reservoirs.