A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-γ productions in murine spleen cells induced by Con-A

Wang, Meiqi; Guilbert, Larry J.; Li, Jie; Wu, Yingqi; Pang, Peter K.T.; Basu, Tapan K.; Shan, Jie

doi:10.1016/j.intimp.2003.12.002

Cited by 83 publications

(79 citation statements)

References 6 publications

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“…Secondly, the daily dosage of CVT-E002 proved to be critical in achieving alopecia amelioration. The significant increase in immune cells (NK cells and non-NK T/B lymphocytes) in all 3 organs (spleen, bone marrow and blood) in the presence of CVT-E002, in vitro and in vivo, under normal and disease conditions, is consistent with several previous observations by other laboratories as well as our own (Wang et al, 2001;2004;Miller et al, 2009;2011a;Durairaj and Miller, 2012;2013). The immune privilege with which the anagen (hair follicle growth center) is imbued under normal conditions is based on numerous carefully balanced factors.…”

Section: Discussionsupporting

confidence: 93%

“…Both biological and chemical standardized assays were applied together with consistent manufacturing processes to ensure that both the composition and the pharmacological activity of each lot of CVT-E002 was identical (Wang et al, 2001;Shan et al, 2007), and free of microbial contaminants. The extract is a strong immune stimulant in vivo and in vitro, and results in increased production of several lymphocyte-stimulating cytokines (Wang et al, 2001;2004).…”

Section: The Dietary Additivementioning

confidence: 99%

“…Res 6 effects, not the least of which is the secondary development of other pathological conditions (Henderson and Ilchyshyn, 1995;Tosti et al, 1989). Some success has also been achieved with laser treatment, quercetin, phytoestrogens, genistein, and aromatherapy (Hay et al, 1998;McElwee et al, 2003;Wikramanayake et al, 2011;.…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we have used a well-established mouse model of human alopecia areata, i.e., the C3H strain (Sundberg et al, 1994;McElwee et al, 2002;McElwee et al, 2003;Wikramanayake et al, 2011;, to investigate the effect of a proprietary, standardized extract of North American ginseng on hair re-growth and maintenance. We have found that daily dietary intake of an extract of North American ginseng, resulted in hair re-growth in such alopecic mice and retention of full body hair long after removing the extract from the diet.…”

Section: Introductionmentioning

confidence: 99%

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Decades of study on alopecia areata have concluded that the condition results from an autoimmune attack on the hair follicle growth center (anagen). In this study, we have used C3H mice, the established model of human alopecia areata. Elderly mice (18 months), almost completely alopecic, were placed on a daily conventional diet (6gm chow/mouse) for 32 weeks (8 months), into which 80mg/mouse of CVT-E002 (a proprietary extract of North American ginseng), was homogenized. These mice began to show hair re-growth after only 2 weeks, with complete hair re-growth by week 32 at which time they were euthanized. The absolute numbers (x10 6 ) of natural killer (NK) immune cells, and of non-NK immune cells (T/B lymphocytes) in mice consuming CVT-E002, were significantly more abundant (p< 0.0001) in both the spleen and bone marrow than in the corresponding organs of parallel, control-diet alopecic mice. In a second group of experiments, CVT-E002 was removed from the diet at week 32 and mice were placed on the control diet for the following 14 weeks (3½ months). All these mice retained their fully re-grown coats. At that time, mice were aged 29 ½ months (2½ years), i.e., 80-90 years of age in humans.

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Section: Discussionsupporting

confidence: 93%

Section: The Dietary Additivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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“…Dr. Basu's research addressed these complex issues and provided critical evaluations of the validity of their clinical efficacy claims, and described an approach to a randomized, double-blind placebo-controlled clinical trial, which were designed taking into account the complexities that are involved in NHPs. The plants (and their products) that he investigated include germinated wheat [27], rhubarb (rheum rhaponticum) [28][29][30], echinacea (purpurea) [31][32][33], fenugreek (trigonella foenum-graecum L.) [34,35], and North American ginseng (panax quinque folium) [36][37][38].…”

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confidence: 99%

Hot Topic: [Recent Concepts in Nutrition (Guest Editor: Ram B Singh)]

Ioannides¹,

Hanlon²,

Konsue³

2010

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's earlier research had focused on the metabolism of vitamins, particularly retinol, ascorbic acid and thiamin. He had studied the relationship of these vitamins with malignant diseases. Highlights of his work include: a) establishing a link between biochemical evidence of secondary deficiency of vitamin A due to its metabolic unavailability and cancers of the epithelial cell origin, such as bronchus, lung and endometrium in humans [1-5]; b) determining an association between breast cancer, especially with skeletal metastases and ascorbic acid deficiency as well as providing mechanistic beneficial effects of ascorbic acid supplement to these patients [6,7]; and

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