A prospective association between dietary folate intake and type 2 diabetes risk among Korean adults aged 40 years or older: the Korean Multi-Rural Communities Cohort (MRCohort) Study

Abstract

It has not been well established whether dietary folate intake reduces the risk of diabetes development. We aimed to clarify the prospective association between dietary folate intake and type 2 diabetes (T2D) risk among 7333 Korean adults aged 40 years or older who were included in the Multi-Rural Communities Cohort. Dietary folate intake was estimated from all 106 food items listed on a FFQ, not including folate intake from supplements. Two different measurements of dietary folate intake were used: the baseline consumption and the average consumption from baseline until just before the end of follow-up. The association between folate intake and T2D risk was determined through a modified Poisson regression model with a robust error estimator controlling for potential confounders. For 29 745 person years, 319 cases of diabetes were ascertained. In multivariable analyses, dietary folate intake was inversely associated with risk of T2D for women, not for men. For women, the incidence rate ratio of diabetes in the third tertile compared with the first tertile was 0·57 (95 % CI 0·38-0·87, P for trend=0·0085) in the baseline consumption model and 0·64 (95 % CI 0·43-0·95, P for trend=0·0244) in the average consumption model. These inverse associations was found in both normal fasting blood glucose group and impaired fasting glucose group among women. Among non-users of multinutrients and vitamin supplements, the significant inverse association remained. Thus, higher dietary intake of folate is prospectively associated with lower risk of diabetes for women.

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

“…Previous studies have shown lower folate levels and higher homocysteine levels in patients with T2D as compared with non-diabetic subjects [ 27 – 29 ]. A cohort study showed that dietary folate intake was inversely associated with risk of T2D for women, not for men [ 30 ]. Moreover, T2D patients with cognitive decline predispose to have lower folate levels compared with T2D patients without cognitive decline [ 5 ].…”

Epigenetics in Human Obesity and Type 2 Diabetes

“…Additionally, these folate levels correlated positively with the average degree of DNA methylation of 236 CpG sites with significantly decreased methylation in liver biopsies from T2D versus control subjects (Nilsson et al., 2015). Moreover, a higher dietary intake of folate was prospectively associated with a lower risk of diabetes in women (Hong et al., 2017). When a subclinical folate deficiency was created in postmenopausal women, plasma homocysteine increased and lymphocyte DNA methylation decreased (Jacob et al., 1998).…”

Faktor Risiko Diabetes Mellitus Tipe 2 Pada Populasi Asia: A systematic Review

“…Faktor risiko DM tipe 2 yang disebabkan oleh pengaruh lingkungan telah dilaporkan oleh banyak peneliti. Dari hasil kajian sistematik ini diketahui bahwa paling tidak terdapat 9 kelompok faktor risiko DM tipe 2 dari faktor lingkungan, yaitu gangguan pada profil kimia darah (Guo et al, 2013;Sun et al, 2014;Akter et al, 2016;Leng et al, 2017;Lu et al, 2017;Urano et al, 2017;Yamaguchi et al, 2017;Choi et al, 2018;Shen et al, 2018), diet atau asupan zat nutrisi yang salah (Akter et al, 2017;Hong et al, 2017;Shan et al, 2018), gaya hidup (lifestlyle) yang buruk (Sakurai et al, 2013;Lou et al, 2015;, profil antrapometri yang bermasalah (Lim et al, 2013;Heianza et al, 2014;Wang et al, 2014;Cho et al, 2015;Chun et al, 2015;Xue et al, 2015;Lv et al, 2016;Zhang et al, 2016;Akter et al, 2017;Son et al, 2017;Yokomichi et al, 2017), kondisi gangguan/penyakit lain (Lee et al, 2013;Feng et al, 2014;Abraham et al, 2015;Akter et al, 2017;Subekti et al, 2017;Yamaguchi et al, 2017), gangguan sistem reproduksi (Yang et al, 2016;Wang et al, 2018), riwayat DM dalam keluarga (Vijayakumar et al, 2017), jenis pekerjaan sehari-hari (Gao et al, 2017), dan faktor risiko lain yaitu kondisi pendapatan dalam keluarga dan kondisi iklim saat lahir Si et al, 2017).…”