A Prospective Controlled Study of Magnetic Resonance Imaging of the Brain in Gay Men and Parenteral Drug Users With Human Immunodeficiency Virus Infection

Dooneief, George; Bello, Jacqueline A.; Todak, George; Mun, In Ki; Marder, Karen; Malouf, Renee; Gorman, Jack M.; Hilal, S. K.; Stern, Yaakov; Mayeux, Richard

doi:10.1001/archneur.1992.00530250042014

Cited by 39 publications

(7 citation statements)

References 31 publications

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“…Seventy-five HIV-positive men and 38 HIV-negative men agreed to participate in an adjunctive magnetic resonance imaging study. No differences were observed between the two groups, nor was level of HIV illness progression associated with degree of atrophy or foci of increased signal (21). Throughout the 4 years of observation, only five cases of AIDSrelated dementia were identified (22).…”

Section: Discussionmentioning

confidence: 87%

Stability of mood despite HIV illness progression in a group of homosexual men

Rabkin

Goetz²,

Remien³

et al. 1997

AJP

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B oth doctors and patients often assume that people with terminal illnesses are apt to become clinically depressed, especially as death approaches. Rarely, however, has this assumption been studied systematically or prospectively. Our data allow us to shed some light on whether clinical depression is an inevitable or even likely concomitant of fatal illness.While several large studies have generated prevalence rates of mood disorders among HIV-positive and HIVnegative men and women on a cross-sectional basis, there is a paucity of information about longitudinal changes in rates of either syndromal disorders or psychiatric symptoms as HIV illness progresses. Joseph et al. (1) found stable scores over six semiannual occasions on self-rating scales of depression in the Chicago Multicenter AIDS Cohort Study group, despite HIV illness progression. Perry et al. (2) followed 328 homosexual and heterosexual men and women, both HIV negative and HIV positive, who sought HIV antibody testing. Over a 1-year period, they found a decline in severity of depressive symptoms on both clinician-and self-rated scales, but no difference between HIV-positive and HIV-negative subjects on any occasion.A pair of studies (3, 4), published in the Journal of the American Medical Association, followed community cohorts of homosexual men semiannually since 1985. Both used the same self-report screening scale for mood problems (Center for Epidemiologic Studies Depression [CES-D] Scale). Neither study found a significant relation between CES-D Scale scores and the time to either diagnosis of AIDS or death, although they differed regarding the effect of depressive symptoms on the rate of decline of CD4 cells.

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Section: Discussionmentioning

confidence: 87%

Stability of mood despite HIV illness progression in a group of homosexual men

Rabkin

Goetz²,

Remien³

et al. 1997

AJP

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“…Additionally, decreased white matter volume in HIV seropositive individuals has been associated with dementia (35). However, in other studies, no relationship was identified between presence of WMHs and cognitive performance (36)(37)(38). Additionally, there is evidence that development of dementia in HIV infection may be associated with atrophy of other brain regions such as the basal ganglia and hippocampus (39).…”

Section: Discussionmentioning

confidence: 91%

Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study

McMurtray

Nakamoto

Shikuma

et al. 2008

Journal of Stroke and Cerebrovascular Diseases

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“…Additionally, the presence of dementia in HIV is associated with decreased white matter volume [24]. However, other studies have reported no relationship between WMH and cognitive performance in HIV infection [25,26,27]. This discrepancy has been partially resolved with the advent of newer neuroimaging techniques which allow improved detection of white matter injury [28, 29], and provide further support for a relationship between white matter damage and severity of cognitive impairment in HIV-seropositive individuals [30,31,32,33,34].…”

Section: Discussionmentioning

confidence: 99%

Small-Vessel Vascular Disease in Human Immunodeficiency Virus Infection: The Hawaii Aging with HIV Cohort Study

McMurtray¹,

Nakamoto²,

Shikuma³

et al. 2007

Cerebrovasc Dis

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Background: This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals. Methods: Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging of the brain of 57 HIV-seropositive individuals. Results: Cerebral small-vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters. Conclusions: These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small-vessel ischemic vascular disease than HIV-related CNS pathology, and support the need for aggressive treatment of vascular risk factors in HIV-seropositive individuals.

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A Prospective Controlled Study of Magnetic Resonance Imaging of the Brain in Gay Men and Parenteral Drug Users With Human Immunodeficiency Virus Infection

Abstract: \s=b\To detect the earliest structural changes in the brain in human immunodeficiency virus (HIV) infection, 118 gay men and 115 parenteral drug users enrolled in a study of the natural history of HIV infection underwent magnetic resonance imaging evaluations.

Cited by 39 publications

References 31 publications

Stability of mood despite HIV illness progression in a group of homosexual men

Stability of mood despite HIV illness progression in a group of homosexual men

Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study

Small-Vessel Vascular Disease in Human Immunodeficiency Virus Infection: The Hawaii Aging with HIV Cohort Study

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