In an effort to increase the cure rate of carcinoma of the head of the pancreas involving the portal system and/or associated arteries, en bloc radical pancreatectomy with associated vascular structures was performed. Twenty-one patients treated by en bloc pancreatectomy had 1-, 2-, and 3-year survival rates of 32.4, 16.2, and 8.2%, respectively, as compared to 15 patients undergoing standard pancreatectomy with 1- and 2-year survival rates of 13.2 and 0%, respectively. Although long-term survival after radical pancreatectomy is limited at present, this procedure often seems to afford the best hope of curing patients with deeply invasive carcinoma of the pancreas.