A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors

Abstract

BackgroundNutrients such as ω-3 fatty acids including fish oil components eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress the growth and promote apoptosis of tumor cells, improve immune function and reduce the effects of systemic inflammatory response syndrome. We sought to investigate the effect of ω-3 fish oil fat emulsion-based parenteral nutrition (PN) on nutritional state, immune function, inflammatory reaction, expression of tumor factors and complication incidence in patients after surgical resection of gastric cancer.MethodsForty-eight patients after surgical operation of gastric tumor in hospital were randomly divided into the control group and intervention group. Patients in both groups were treated with iso-nitrogen and iso-caloric parenteral nutrition support. In addition, the intervention group received ω-3 fish oil fat emulsion and the control group received soybean oil. The indicators of nutrition, immune function and inflammation in the two groups were detected on the day before the operation and postoperative day 6. The rate of complication was compared between the two groups.ResultsThere was no significant difference in nutritional state, liver function and renal function between the two groups (P > 0.05). However, the levels of inflammatory markers were significantly decreased (P < 0.01), and the rate of complication was also decreased in the intervention group as compared with the control group.Conclusionsω-3 fish oil fat emulsion-based parenteral nutrition alleviates the inflammatory reaction and reduces the rate of inflammatory complications.

PEMBERIAN MINYAK IKAN LELE (Clarias gariepinus) TERHADAP BOBOT BADAN DAN PERUBAHAN HISTOPATOLOGI HATI, GINJAL DAN OTAK TIKUS GALUR Sprague dawley YANG DIBERI PAKAN HIPERKOLESTEROLEMIA

“…Minyak ikan diketahui mengandung omega 3 dan omega 6 yang bermanfaat bagi kesehatan jika dikonsumsi sebagai suplemen (Minis et al 2006). Beberapa penelitian menunjukkan bahwa omega 3 dapat menurunkan kadar trigliserida, meningkatkan High Density Lipoprotein (HDL) dan menurunkan kadar Low Density Lipoprotein (LDL) (Covington 2004); mengurangi risiko kerusakan dan penurunan kemampuan kognitif pada lansia (Gonzales et al 2010); meredakan reaksi inflamasi dan mengurangi tingkat komplikasi inflamasi (Wei et al 2014). Cooper (2003) mengatakan bahwa hal ini disebabkan lemak tak jenuh seperti omega 3 diperkirakan memiliki sifat melindungi (protektif) sel saraf dari risiko PA.…”

Effects of parenteral nutrition of ω-3 polyunsaturated fatty acid, arginine and glutamine on cellular immune status of patients following liver cancer surgery

“…Unsaturated fatty acids as precursors of prostaglandins, are important components of cell membranes, which maintain the fluidity of cell membranes, and participate in the regulation of cellular and biochemical responses [7]. Fish oil/kg body weight/day (0.2 g) in addition to TPN has been recommended to be taken by gastrointestinal tumor patients after surgery, for reduction of inflammatory response syndrome and post-operative recovery, on the basis of the fact that ω-3 unsaturated fatty acids inhibit the formation of pro-inflammatory factors (IL-6 and TNF-a), increase the synthesis of antiinflammatory factor IL-10, improve immune function and eliminate excessive inflammation [8,9].…”

Parenteral Nutrition Enriched with Fish Oil after Gastrointestinal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…Figure 1 shows the process for identifying potentially eligible studies and exclusion criteria. After elaborative screening, 34 articles were assessed by full text and 17 studies with 753 patients [2,[10][11][12]15,16,[23][24][25][26][27][28][29][30][31][32][33] were included for the review. However, three publications [2,24,30,31,33] are same study that reported different outcomes.…”

“…Nine studies reported the occurrence of infectious postoperative complications [11,12,23,26,27,[29][30][31][32]. The incidence of infection was 8.8% in the intervention group (24/273) and 20.1% in the control group (56/271).…”

“…The analysis of four [12,[30][31][32] and five [12,16,[30][31][32] studies showed a significant reduction in values of pro-inflammatory cytokines IL-6 and TNF-α, respectively, within the intervention group compared with the control group. The mean difference for IL-6 was -7.03 (95% CI, -11.10 to -2.97, P = 0.0007, heterogeneity I 2 = 49%) and for TNF-α was -1.18 (95% CI, -1.71 to -0.66, P<0.0001, heterogeneity I 2 = 9%).…”