A Prospective Randomized Controlled Trial Comparing N-butyl-2 Cyanoacrylate (Histoacryl), Octyl Cyanoacrylate (Dermabond), and Subcuticular Suture for Closure of Surgical Incisions

Koonce, Stephanie L.; Eck, Dustin L.; Shaddix, Kyle K.; Perdikis, Galen

doi:10.1097/sap.0b013e318289856f

Cited by 30 publications

(17 citation statements)

References 11 publications

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“…23 Similarly, several recent trials have demonstrated that wound closure with OCA offers comparable scar cosmesis compared to repair with sutures. [24][25][26][27][28][29] In accord with our results, a 2014 Cochrane review and meta-analysis found that wound closure with tissue adhesives resulted in significantly more episodes of wound dehiscence than sutures. 30 Strengths of this study include its use of a validated scar assessment tool by blinded observers, a priori data analysis, and larger sample size relative to similar published studies.…”

Section: Discussionsupporting

confidence: 81%

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

et al. 2020

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BACKGROUND Although the use of 2-octylcyanoacrylate (OCA) in cutaneous surgery offers increased efficiency, there is scant data comparing scar outcomes achieved with OCA versus 5-0 fast-absorbing gut suture (FG). OBJECTIVE To compare scar cosmesis achieved with OCA versus FG for surgical wound closure. MATERIALS AND METHODS A total of 44 patients with postoperative defects of at least 3 cm were included. Half of each wound was randomized to receive closure with either OCA or FG. At 3 months, patients and 2 blinded observers evaluated each scar using the Patient and Observer Scar Assessment Scale (POSAS). RESULTS The total observer POSAS score (mean [SD]) for the side repaired with OCA (12.3 [4.72]) and the side that received FG (11.6 [4.36]) did not differ significantly (p = .40). There was no significant difference in the total patient POSAS scores between closure with OCA (14.9 [8.67]) and FG (14.6 [8.90]) (p = .70). Based on observer POSAS scores, scar pigmentation was significantly worse on the scar half repaired with OCA (1.98 [0.91]) compared with FG (1.79 [0.80]) (p = .05). CONCLUSION With the exception of inferior scar pigmentation with OCA, there was no statistically significant difference in wound cosmesis after linear wound closure with OCA versus FG.

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Section: Discussionsupporting

confidence: 81%

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

et al. 2020

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“…In prospective trials, however, fibrin‐based glues did not show a benefit in sealing high‐output fistulas, mainly due to the glues' weak adhesive strength . Methacrylate adhesives “superglue” are strong adhesives commonly used as Dermabond for wound closure, polymethyl methacryclate in kyphoplasty, or histo‐acryl glue in cardiac surgery . Methacrylates have also been used experimentally in some fistulas, but their application can be technically challenging, especially with catheters, as glues polymerize during delivery.…”

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confidence: 99%

Supramolecular Metallo‐Bioadhesive for Minimally Invasive Use

et al. 2016

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“…Porém, em relação aos adesivos biológicos (fibrina) e sintéticos (cianoacrilato), verificou-se que os adesivos biológicos apresentam menor resistência à tração e menor tempo de polimerização. Além disso, eles têm o potencial de transmissão da doença em comparação com adesivos sintéticos (Koonce et al, 2015).…”

Section: Discussionunclassified

Uso da cola de cianoacrilato como alternativa em procedimentos cirúrgicos: uma revisão integrativa

Filho¹,

Pardinho²,

Avena³

et al. 2021

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Objetivo: Verificar se o uso da cola de cianoacrilato em procedimentos cirúrgicos produz desfechos benéficos para o paciente, no que diz respeito à cicatrização e custo benefício. Métodos: Foi realizada uma revisão integrativa da literatura nas bases de dados PubMed, Bireme/BVS e SciELO, sendo incluídos artigos que se referiam a cianoacrilatos, cirurgias e suturas em seres humanos. Artigos de revisão da literatura, dissertações, capítulos de livros, estudos de caso e editoriais, além dos textos duplicados, foram excluídos. Resultados: Foram encontrados 897 artigos, dos quais 830 foram excluídos após aplicação dos critérios de inclusão e exclusão, e após a leitura dos resumos e textos na íntegra. Assim, 67 artigos foram incluídos nesta revisão. Conclusão: Os estudos demonstraram que as colas de cianoacrilato podem ser utilizadas como alternativa em procedimentos cirúrgicos, principalmente pela facilidade de aplicação, diminuição do risco de contaminação e aumento da eficácia da cicatrização. Apesar de não substituírem as suturas em todos os procedimentos cirúrgicos, as colas de cianoacrilato constituem-se como um método rápido, barato e eficaz, com melhor custo-benefício e tempo de cicatrização, especificamente, nas cirurgias plásticas, oftalmológicas e cardíacas.

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A Prospective Randomized Controlled Trial Comparing N-butyl-2 Cyanoacrylate (Histoacryl), Octyl Cyanoacrylate (Dermabond), and Subcuticular Suture for Closure of Surgical Incisions

Abstract: Our results demonstrate a decreased time required for wound closure using N-butyl-2 cyanoacrylate compared to both suture and octyl cyanoacrylate regardless of incision type with no significant difference in scar width or satisfaction ratings.

Cited by 30 publications

References 11 publications

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

Supramolecular Metallo‐Bioadhesive for Minimally Invasive Use

Uso da cola de cianoacrilato como alternativa em procedimentos cirúrgicos: uma revisão integrativa

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