A Prospective, Randomized, Single-blinded Controlled Trial on Biodegradable Synthetic Polyurethane foam as a Packing Material after Septoplasty

Abstract

SPF is as suitable as Merocel to be used after septoplasty with beneficial effects on bleeding and pain at packing removal.

Merocel versus Nasopore for Nasal Packing: A Meta-Analysis of Randomized Controlled Trials

“…A total of 459 potentially relevant articles were identified from the initial search; however, most were retrospective studies, review articles, non-randomized studies, case reports, or not relevant to the aim of the present study, or provided irrelevant data. Ultimately, seven trials [6]–[8], [11]–[14] were identified as eligible, all of which were RCTs published from 2009 to 2013, and consensus on study selection was reached by discussion among the researchers. Characteristics of eligible trials are summarized in Table 1.…”

“…One trial reported allocation concealment with a sealed envelope [6], but concealment of allocation was an undefined risk in the other studies because it was not reported. Double blinding method was applied in one study [8], single blinding of patients in two [6], [12], and unmasked designation in one [7], blinding was not reported in the remaining three [11], [13], [14]. Funding biases were not evident in any of the studies, and they did not have baseline imbalances.…”

“…Two trials have reported that Nasopore packing caused significantly less pain and bleeding during removal than did Merocel packing [6], [7]; another study showed little difference in nasal symptoms between the two packing materials 5 days after surgery [8], and still another reported that Nasopore was a significant factor in the formation of excessive granulation tissue 3–4 weeks after FESS [9]. To address this issue, we performed a meta-analysis that included all available data from randomized controlled trials (RCTs) that compared Merocel with Nasopore as a packing material at the end of nasal surgery with regard to the subjective severity of the symptoms.…”

Effect of Aerosolized Fibrin Sealant on Hemostasis and Wound Healing after Endoscopic Sinus Surgery: A Prospective Randomized Study

“…In addition, during the removal of the Merocel packing, the possibility of bleeding from the epithelium is increased as bloody crusts or blood clots present between the Merocel packing and the nasal mucosa may be removed at the same time, which would result in more crusting and the formation of granulation tissue. 32 Several other studies have reported that using FS for endonasal surgeries, including septoplasty and conchotomy, is effective in producing postoperative hemostasis. 25,26,[34][35][36] Gleich et al 37 found that autologous fibrin tissue adhesives provided reliable hemostasis, decreased crusting, accelerated mucosal healing, and diminished synechiae.…”

Transseptal Suturing Reduce Patient Anxiety after Septoplasty Compared to Nasal Packing

“…Many forms of nasal packing are available, including Merocel, "rapid rhino", the "Doyle pack", gauze with vaseline, and synthetic polyurethane. These are placed after surgery to prevent bleeding, septal hematoma, and septal abscess (13,14). Although the packs afford many advantages, they increase the risk of infection and cause pain (15).…”