A prospective randomized study comparing amoxycillin/ clavulanate with cefuroxime plus metronidazole for perioperative prophylaxis in gynaecological surgery

Linden, M.C.G.J. van der; Erp, E. J. M. Van; Ruijs, G. J. H. M.; Holm, Jonas

doi:10.1016/0028-2243(93)90178-f

Cited by 15 publications

(4 citation statements)

References 14 publications

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“…Amoxicillin‐clavulanic acid is a relatively inexpensive broad‐spectrum drug that has been studied in several comparative trials of prophylaxis in abdominal, and gynecologic surgery. In clinical trials that studied amoxicillin‐clavulanic acid as surgical prophylaxis in gynecologic indication it was proved that this regimen was more cost‐ effective than cefuroxime plus metronidazole (6), cephradime plus metronidazole (9), metronidazole alone (8), and piperacilline alone (7). Cefazolin is the most commonly used drug in North America in surgical prophylaxis (1,5).…”

Section: Discussionmentioning

confidence: 99%

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Prospective randomized study comparing amoxicillin‐clavulanic acid with cefazolin as antimicrobial prophylaxis in laparotomic gynecologic surgery

Cormio

Fazio

Cacciapuoti

et al. 2003

Acta Obstet Gynecol Scand

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Section: Discussionmentioning

confidence: 99%

“…Numerous studies have been published in recent years about antimicrobial prophylaxis in gynecologic surgery, however, the optimal drug and schedule for the different surgical procedures are still matters of debate (5–10).…”

mentioning

confidence: 99%

Prospective randomized study comparing amoxicillin‐clavulanic acid with cefazolin as antimicrobial prophylaxis in laparotomic gynecologic surgery

Cormio

Fazio

Cacciapuoti

et al. 2003

Acta Obstet Gynecol Scand

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“…On the other hand, Stiver et al did not find a statistically significant difference regarding development of UTI between patients undergoing vaginal hysterectomy receiving single-dose ceftriaxone and multidose cefazolin prophylaxis [13]. Also, Van der Linden et al found no difference in UTI rates in patients undergoing vaginal hysterectomy with or without colporrhaphy and receiving amoxicillin/clavulanate versus cefuroxime plus metronidazole [14]. Brouwer and Hoogkamp-Korstanje did not find a statistically significant difference regarding development of UTI in patients receiving single-dose ceftriaxone or cefuroxime plus metronidazole prophylaxis [15].…”

Section: Comparisons Between Two Antibiotic Regimensmentioning

confidence: 96%

Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review

et al. 2008

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We evaluated the prevalence of urinary tract infection (UTI) after pelvic floor operations for non-malignant etiology and the effectiveness of antibiotic prophylaxis. This was made possible by a review of the evidence from relevant randomized controlled trials (RCTs). Nineteen out of 879 initially identified studies met the criteria for inclusion in our review. Four RCTs compared an antibiotic prophylactic regimen with placebo, 11 two different prophylactic antibiotic regimens, and four had three different treatment arms. Among placebo recipients undergoing pelvic floor surgery, 10-64% developed UTI. In contrast, UTI after pelvic floor gynecological surgery occurred in 0-15% of the patients who received cephalosporins as antibiotic prophylaxis; the likelihood for postoperative UTI was higher for patients receiving cotrimoxazole (28%), ampicillin/sulbactam (13.6%), metronidazole plus ampicillin (20%), metronidazole (10-22.7%), or ciprofloxacin (27.2%). The use of a cephalosporin as perioperative antimicrobial prophylaxis is the optimal regimen in preventing UTIs after pelvic floor surgery.

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“…Cefuroxime in combination with metronida zole is often used in this field and there is some experi ence with a single dose regimen [5,6]. We compared the prophylactic efficacy of this regimen with that o f cef triaxone.…”

Section: Introductionmentioning

confidence: 99%

Single dose ceftriaxone versus single dose cefuroxime plus metronidazole for preventing febrile morbidity and urinary tract infection in vaginal hysterectomy

Brouwer¹,

Korstanje²

1995

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To compare the prophylactic efficacy o f 1 g ceftriaxone with 1,5 g cefuroxime + 0.5 g metronidazole for febrile morbid ity and urinary tract infection in patients undergoing vaginal hysterectomy. Study design: A prospective, randomized, comparative, non-blinded study with at least 100 patients on each side. The two-sample /-test was used for testing equality o f two means and the x 2 test was used for pair differences. Results: Single dose cefuroxime + metronidazole and ceftriaxone were equally effective in preventing febrile morbidity postoperatively. Additionally ceftriaxone was more effective in sterilizing pre-operatively existing bacteriuria.

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A prospective randomized study comparing amoxycillin/ clavulanate with cefuroxime plus metronidazole for perioperative prophylaxis in gynaecological surgery

Cited by 15 publications

References 14 publications

Prospective randomized study comparing amoxicillin‐clavulanic acid with cefazolin as antimicrobial prophylaxis in laparotomic gynecologic surgery

Prospective randomized study comparing amoxicillin‐clavulanic acid with cefazolin as antimicrobial prophylaxis in laparotomic gynecologic surgery

Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review

Single dose ceftriaxone versus single dose cefuroxime plus metronidazole for preventing febrile morbidity and urinary tract infection in vaginal hysterectomy

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