A Prospective Randomized Study Comparing Woven Polyglycolic Acid and Autogenous Vein Conduits for Reconstruction of Digital Nerve Gaps

Rinker, Brian; Liau, James Y.

doi:10.1016/j.jhsa.2011.01.030

Cited by 107 publications

(58 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For nerve defects, which were never greater than 3 cm, Laveaux et al could demonstrate that nerve grafting was superior to vein grafting [56]. Rinker and Liau showed in a prospective randomized controlled study that digital nerve reconstructions with autologous vein grafts were comparable to the use of PGA conduits with regard to sensory recovery (gap lengths: 0.4–2.5 cm) [99]. Furthermore, the use of artificial conduits was associated with a slightly higher postoperative complication rate compared to the use of vein grafts [99].…”

Section: Discussionmentioning

confidence: 99%

Sensory Recovery Outcome after Digital Nerve Repair in Relation to Different Reconstructive Techniques: Meta-Analysis and Systematic Review

Paprottka

Wolf

Harder

et al. 2013

Plastic Surgery International

View full text Add to dashboard Cite

Good clinical outcome after digital nerve repair is highly relevant for proper hand function and has a significant socioeconomic impact. However, level of evidence for competing surgical techniques is low. The aim is to summarize and compare the outcomes of digital nerve repair with different methods (end-to-end and end-to-side coaptations, nerve grafts, artificial conduit-, vein-, muscle, and muscle-in-vein reconstructions, and replantations) to provide an aid for choosing an individual technique of nerve reconstruction and to create reference values of standard repair for nonrandomized clinical studies. 87 publications including 2,997 nerve repairs were suitable for a precise evaluation. For digital nerve repairs there was practically no particular technique superior to another. Only end-to-side coaptation had an inferior two-point discrimination in comparison to end-to-end coaptation or nerve grafting. Furthermore, this meta-analysis showed that youth was associated with an improved sensory recovery outcome in patients who underwent digital replantation. For end-to-end coaptations, recent publications had significantly better sensory recovery outcomes than older ones. Given minor differences in outcome, the main criteria in choosing an adequate surgical technique should be gap length and donor site morbidity caused by graft material harvesting. Our clinical experience was used to provide a decision tree for digital nerve repair.

show abstract

Section: Discussionmentioning

confidence: 99%

Sensory Recovery Outcome after Digital Nerve Repair in Relation to Different Reconstructive Techniques: Meta-Analysis and Systematic Review

Paprottka

Wolf

Harder

et al. 2013

Plastic Surgery International

View full text Add to dashboard Cite

show abstract

“…Excellent nerve regeneration and functional recovery were observed in rats[4] and rabbits[39] who underwent autogenous vein grafting for repair of peripheral defects of less than 30 mm. Autogenous vein grafts were also effective in clinical studies, with recovery of two-point discrimination in patients with short digital nerve defects that were bridged by vein grafts[21404142]. Currently, autogenous vein grafts are mainly used to repair nerve defects of less than 30 mm because veins have little mechanical resistance to kinking and collapse[4344].…”

Section: Discussionmentioning

confidence: 99%

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

2014

View full text Add to dashboard Cite

Motor reinnervation after repair of tibial nerve defects using autologous vein grafts in rats has previously been reported, but sensory reinnervation after the same repair has not been fully investigated. In this study, partial sensory reinnervation of muscle spindles was observed after repair of 10-mm left tibial nerve defects using autologous vein grafts with end-to-end anastomosis in rats, and functional recovery was confirmed by electrophysiological studies. There were no significant differences in the number, size, or electrophysiological function of reinnervated muscle spindles between the two experimental groups. These findings suggest that repair of short nerve defects with autologous vein grafts provides comparable results to immediate end-to-end anastomosis in terms of sensory reinnervation of muscle spindles.

show abstract

“…Further analysis showed that PGA conduits were equivalent or superior to traditional autografts in less than 4-and 9-30-mm gaps [145]. Other researchers also compared PGA conduits and vein grafts to repair digital nerve gaps up to 4 cm and equivalent or superior recovery was obtained [146,147]. Further experiments have demonstrated the success of bioabsorbable PGA nerve conduits in the regeneration of nerve defects [148][149][150][151].…”

Section: Polyglycolic Acidmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

show abstract

A Prospective Randomized Study Comparing Woven Polyglycolic Acid and Autogenous Vein Conduits for Reconstruction of Digital Nerve Gaps

Cited by 107 publications

References 30 publications

Sensory Recovery Outcome after Digital Nerve Repair in Relation to Different Reconstructive Techniques: Meta-Analysis and Systematic Review

Sensory Recovery Outcome after Digital Nerve Repair in Relation to Different Reconstructive Techniques: Meta-Analysis and Systematic Review

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Contact Info

Product

Resources

About