A prospective randomized study on the use of nadroparin calcium in the prophylaxis of thromboembolism in Korean patients undergoing elective total hip replacement

Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography

“…In previous Asian studies of major orthopedic surgery followed by systematic venography, the reported rates of total DVT varied widely, ranging between 0% and 64% after THR [7][8][9][10][11][12], 11% and 77% after TKR [9,[13][14][15][16][17], and 7% and 50% after HFS [8,9,18,19]. However, these studies were heterogeneous, with sample sizes ranging between 14 [9] and 244 patients [14].…”

Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study

“…Again, previous small epidemiological studies performed in Asian patients undergoing major orthopedic surgery, and using different designs and confirmatory diagnostic tools, gave disparate results with rates of symptomatic events ranging from 0.0% to 47.1%. [20][21][22][23][24][25] However, in the recently reported large epidemiological study in 2420 Asian patients (11 Asian countries) undergoing major orthopedic surgery (SMART), the rates of the composite of adjudicated confirmed symptomatic venous thromboembolism or sudden death were 1.2% (99% CI: 0.7-1.8) up to hospital discharge and 1.5% (99% CI: 1.0-2.3) at 1 month, 2 which are similar to those found in our study. Recent data regarding the rate of symptomatic events in Western patients undergoing orthopedic surgery without receiving thromboprophylaxis are limited.…”

“…To our knowledge, only five small open studies have evaluated a prophylactic method in Asian patients. 18,[31][32][33][34] These studies were small in size and the beneficial effect of treatment was in general not statistically significant, but all showed that prophylaxis could reduce the rate of venous thromboembolism to some extent. Although these data should be confirmed in larger well-conducted multicenter studies, we believe that there is no reason why the benefit of thromboprophylaxis, well documented in the West, 4 should not also be achieved in Asian patients.…”

Is pre-operative assessment of coagulation profile with Thrombelastography (TEG) useful in predicting venous thromboembolism (VTE) following orthopaedic surgery?

“…[1][2][3][4][5][6][7][8][9] While many studies have shown that the incidence of deep vein thrombosis (DVT) is lower in Asian patients than the Western population, 1,3,4,9 some of the recent studies from China and south east Asia have shown significant incidence of DVT in high-risk orthopaedic patients. 2,[5][6][7] In India, there are conflicting reports on the incidence of VTE.…”