A prospective series of patients with hyperglycaemia-associated movement disorders

Cervantes-Arriaga, Amín; Arrambide, Georgina; Rodríguez-Violante, Mayela

doi:10.1016/j.jocn.2011.01.029

Cited by 4 publications

(19 citation statements)

References 23 publications

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“…Common to the vast majority of HIIM is that they often resolve within hours to days of improvement/correction of hyperglycemia, supporting a metabolic etiology rather than a purely structural abnormality (2)(3)(4)(5)(6)(7). HIIM are most commonly seen in patients with long-standing, poorly controlled diabetes; often these individuals have a hemoglobin A1C exceeding 10% (2)(3)(4)(5). The glucose levels of our patients on presentation (899 and 577 mg/ dL) were consistent with the degree of hyperglycemia associated with HIIM described in the literature, as were their serum osmolalities and sodium concentrations (2-7).…”

Section: Discussionmentioning

confidence: 99%

Hyperglycemia-Induced Involuntary Movements: 2 Case Reports and a Review of the Literature

Borensztein

Walker

Schell

et al. 2015

AACE Clinical Case Reports

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Objective: Autonomic and peripheral neurologic manifestations of hyperglycemia are commonly seen in clinical practice; acute hyperglycemia-induced involuntary movements (HIIM) are rarer and less well known. In this article we describe 2 patients with HIIM and review the scientific literature to better characterize the clinical and pathophysiologic features of these disorders.Methods: A literature search was performed using the PubMed database. Whenever possible, the most recent publication on a topic was utilized, with a 20-year cutoff time since publication. Articles were selected based on the quality of presented data or citations utilized.Results: HIIM can present in a variety of ways including seizures, hemichorea-hemiballismus (HCHB) and, very rarely, tremor. While HIIM are more commonly seen in patients with long-standing, uncontrolled diabetes, they can also be the initial presentation of diabetes. The precise pathophysiology of HIIM remains unknown; however, at least for HCHB, it is hypothesized that hyperglycemia increases the metabolism of the inhibitory neurotransmit-Abbreviations: HCHB = hemichorea-hemiballismus; HIIM = hyperglycemia-induced involuntary movements; GABA = gamma aminobutyric acid; EPC = epilepsia partialis continua; MRI = magnetic resonance imaging; NKH = nonketotic hyperglycemia

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Section: Discussionmentioning

confidence: 99%

Hyperglycemia-Induced Involuntary Movements: 2 Case Reports and a Review of the Literature

Borensztein

Walker

Schell

et al. 2015

AACE Clinical Case Reports

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show abstract

“…In a prospective study involving hyperglycemia-associated movement disorders, all 10 patients were misdiagnosed on initial evaluation by a general practitioner [4]. Because the number of patients with HCNH reported in the literature is limited, we analyzed the clinical presentation, neuroimaging features, and evolution at follow-up of 12 patients with HCNH.…”

Section: Introductionmentioning

confidence: 99%

Hemichorea Associated with Nonketotic Hyperglycemia: Clinical and Neuroimaging Features in 12 Patients

Guo¹,

Miao²,

Ji³

et al. 2014

Eur Neurol

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Background: Nonketotic hyperglycemia is a rare cause of hemichorea. Patients with hemichorea associated with nonketotic hyperglycemia (HCNH) always have a favorable prognosis when given prompt treatment. Methods: We reviewed the medical records of 12 patients with HCNH in our hospital between January 2005 and January 2013. The clinical data, laboratory findings, and imaging features of the patients were collected. Results: All 12 patients were admitted to the hospital with a complaint of involuntary movements. Ten patients had a history of diabetes, while the other 2 patients had not been diagnosed. The meanlevel of blood glucose on admission was 330.7 ± 107.8 mg/dl, and the ketones were negative. A cranial computed tomography scan showed hyperdensity in the striatum, which quickly resolved. Magnetic resonance imaging showed hyperintensity on T1-weighted images without change over several months. Nearly all of the patients experienced relief from the hemichorea symptoms after correcting hyperglycemia with a combination of dopamine receptor inhibitors and the sedative lorazepam, if necessary. Conclusion: HCNH is a benign disorder, the pathogenesis of which remains unclear. Radiologic changes can provide guidance for early treatment and generally give an estimation of the degree of injury.

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“…2,5,6 Including all reported adult HNKH cases in four major series, the mean age was 70.22 ± 10.85 years, and more than two-thirds (67.1%) of the cases were females. 1,2,5,6 Including our case, HNKH has been reported as an initial manifestation of DM in five (71.4%) of the seven reported pediatric cases to date. 3,4 The mean age of the pediatric HNKH patients was 13.71 ± 2.92 years (Table 1).…”

Section: Jmdmentioning

confidence: 99%

“…[1][2][3][4][5][6] Haloperidol, clonazepam and valproate are commonly used drugs. [1][2][3][4][5][6] Including our case, five (71.4%) of the seven pediatric cases reported amelioration of involuntary movements within a month of onset. 3,4 It remains unclear which clinical factors could predict the final clinical outcome.…”

Section: Jmdmentioning

confidence: 99%

“…1,2,5,6 Both upper and lower limb involvement was observed in the majority of adult cases (93.3%), with additional involvement of the face reported in 20% of cases (Table 1). 1,2,5,6 Occasional cases may have isolated upper limb involvement. 1,5 In the pediatric age group, 85.7% of the cases reported involvement of both upper and lower limbs, with face involvement in 43% of the cases.…”

Section: Jmdmentioning

confidence: 99%

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Pediatric Hemichorea-Hemiballismus Associated with Nonketotic Hyperglycemia: A Case Report and Review of the Literature

Kumar¹,

Prakash

2021

JMD

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A prospective series of patients with hyperglycaemia-associated movement disorders

Cited by 4 publications

References 23 publications

Hyperglycemia-Induced Involuntary Movements: 2 Case Reports and a Review of the Literature

Hyperglycemia-Induced Involuntary Movements: 2 Case Reports and a Review of the Literature

Hemichorea Associated with Nonketotic Hyperglycemia: Clinical and Neuroimaging Features in 12 Patients

Pediatric Hemichorea-Hemiballismus Associated with Nonketotic Hyperglycemia: A Case Report and Review of the Literature

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