A Prospective Study of Autologous Chondrocyte Implantation in Patients with Failed Prior Treatment for Articular Cartilage Defect of the Knee

Zaslav, Kenneth R.; Cole, Brian J.; Brewster, Robert; DeBerardino, Thomas M.; Farr, Jack; Fowler, Peter; Nissen, Carl W.

doi:10.1177/0363546508322897

Cited by 224 publications

(201 citation statements)

References 33 publications

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“…Zaslav et al 67 prospectively followed 154 patients who were treated with an ACI procedure and reported that 77% of patients had good to excellent clinical outcomes based on knee function, knee pain, quality of life, and overall health. Similar prospective studies were completed by Rosenberger et al, 53 who reported that 72% of 56 patients subjectively reported a good to excellent outcome.…”

Section: Restorative Technique: Autologous Chondrocyte Implantationmentioning

confidence: 99%

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

Tetteh¹,

Bajaj²,

Ghodadra³

2012

Journal of Orthopaedic & Sports Physical Therapy

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Synopsis The complex structure of articular cartilage allows for diverse knee function throughout range of motion and weight bearing. However, disruption to the structural integrity of the articular surface can cause significant morbidity. Due to an inherently poor regenerative capacity, articular cartilage defects present a treatment challenge for physicians and therapists. For many patients, a trial of nonsurgical treatment options is paramount prior to surgical intervention. In instances of failed conservative treatment, patients can undergo an array of palliative, restorative, or reparative surgical procedures to treat these lesions. Palliative methods include debridement and lavage, while restorative techniques include marrow stimulation. For larger lesions involving subchondral bone, reparative procedures such as osteochondral grafting or autologous chondrocyte implantation are considered. Clinical success not only depends on the surgical techniques but also requires strict adherence to rehabilitation guidelines. The purpose of this article is to review the basic science of articular cartilage and to provide an overview of the procedures currently performed at our institution for patients presenting with symptomatic cartilage lesions. J Orthop Sports Phys Ther 2012;42(3):243–253. doi:10.2519/jospt.2012.3673

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Section: Restorative Technique: Autologous Chondrocyte Implantationmentioning

confidence: 99%

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

Tetteh¹,

Bajaj²,

Ghodadra³

2012

Journal of Orthopaedic & Sports Physical Therapy

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“…In the early 1990s, Brittberg et al [7] in their initial clinical studies on the effectiveness of ACI, reported good or excellent results in 14 out of 16 patients. Two subsequent clinical trials, conducted in larger groups and longer follow-up terms, showed good-to-excellent results in 76 % [8] and 88 % [9] of patients respectively, indicating that the emerging TE technique would soon replace traditional methods of treatment for cartilage, menisci and ligaments injuries and more suitable cells would be searched for.…”

Section: Cell Sourcesmentioning

confidence: 99%

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Trzeciak

Richter

Suchorska

et al. 2016

International Orthopaedics (SICOT)

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Over 20 years ago it was realized that the traditional methods of the treatment of injuries to joint components: cartilage, menisci and ligaments, did not give satisfactory results and so there is a need of employing novel, more effective therapeutic techniques. Recent advances in molecular biology, biotechnology and polymer science have led to both the experimental and clinical application of various cell types, adapting their culture conditions in order to ensure a directed differentiation of the cells into a desired cell type, and employing non-toxic and non-immunogenic biomaterial in the treatment of knee joint injuries. In the present review the current state of knowledge regarding novel cell sources, in vitro conditions of cell culture and major important biomaterials, both natural and synthetic, used in cartilage, meniscus and ligament repair by tissue engineering techniques are described, and the assets and drawbacks of their clinical application are critically evaluated.

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“…Two studies 30,39 reported the preinjury TAS. The Lysholm scale was applied together with the IKDC Subjective Form in 5 studies, 25,42,43,47,50 but no studies used the Lysholm scale in conjunction with the KOOS. Three studies applied both the IKDC and KOOS.…”

Section: Data Synthesismentioning

confidence: 99%

Measuring Physical Activity and Sports Participation After Autologous Cartilage Implantation: A Systematic Review

Santos-Magalhaes¹,

Hambly²

2014

Journal of Sport Rehabilitation

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Context:The assessment of physical activity and return to sport and exercise activities is an important component in the overall evaluation of outcome after autologous cartilage implantation (ACI). Objective: To identify the patient-report instruments that are commonly used in the evaluation of physical activity and return to sport after ACI and provide a critical analysis of these instruments from a rehabilitative perspective. Evidence Acquisition: A computerized search was performed in January 2013 and repeated in March 2013. Criteria for inclusion required that studies (1) be written in English and published between 1994 and 2013; (2) be clinical studies where knee ACI cartilage repair was the primary treatment, or comparison studies between ACI and other techniques or between different ACI generations; (3) report postoperative physical activity and sport participation outcomes results, and (4) have evidence level of I-III. Evidence Synthesis: Twenty-six studies fulfilled the inclusion criteria. Three physical activity scales were identified: the Tegner Activity Scale, Modified Baecke Questionnaire, and Activity Rating Scale. Five knee-specific instruments were identified: the Lysholm Knee Function Scale, International Knee Documentation Committee Score Subjective Form, Knee Injury and Osteoarthritis Outcome Score, Modified Cincinnati Knee Score, and Stanmore-Bentley Functional Score. Conclusions: Considerable heterogeneity exists in the reporting of physical activity and sports participation after ACI. Current instruments do not fulfill the rehabilitative needs in the evaluation of physical activity and sports participation. The validated instruments fail in the assessment of frequency, intensity, and duration of sports participation.

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A Prospective Study of Autologous Chondrocyte Implantation in Patients with Failed Prior Treatment for Articular Cartilage Defect of the Knee

Cited by 224 publications

References 33 publications

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Measuring Physical Activity and Sports Participation After Autologous Cartilage Implantation: A Systematic Review

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