A Prospective Study of Body Mass Index, Weight Change, and Risk of Cancer in the Proximal and Distal Colon

Laake, Ida; Thune, Inger; Selmer, Randi; Tretli, Steinar; Slattery, Martha L.; Veierød, Marit B.

doi:10.1158/1055-9965.epi-09-0813

Cited by 65 publications

(71 citation statements)

References 45 publications

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“…In contrast to our findings for men, Laake et al (11) reported a relative risk for distal colon cancer of 1.87 (95% CI, 0.93-3.75) for weight gain ≥10 kg but only 1.02 (95% CI, 0.47-2.18) for proximal colon cancer in a Norwegian, populationbased cohort study. They found relative risks of 0.91 (95% CI, 0.43-1.94) and 1.46 (95% CI, 0.83-2.56), respectively, for women.…”

Section: Discussioncontrasting

confidence: 99%

“…We are aware of only one other study that has investigated the association between weight change and risk of colon cancer by tumor subsite (11). In contrast to our findings for men, Laake et al (11) reported a relative risk for distal colon cancer of 1.87 (95% CI, 0.93-3.75) for weight gain ≥10 kg but only 1.02 (95% CI, 0.47-2.18) for proximal colon cancer in a Norwegian, populationbased cohort study.…”

Section: Discussionmentioning

confidence: 99%

“…Several large prospective cohort (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and case-control studies (12,13) have reported positive associations between colon cancer risk and weight or body mass index (BMI) for men, but the evidence is inconsistent for women (1,3,7,8,(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Body Size, Weight Change, and Risk of Colon Cancer

Bassett

Severi

English

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Epidemiologic studies have consistently reported positive associations between obesity and colon cancer risk for men, but the evidence is less consistent for women. Few studies have investigated effects of weight change on colon cancer risk.Methods: Using the Melbourne Collaborative Cohort Study, which recruited men and women mostly in 40 to 69 years of age, we investigated associations between weight and body mass index (BMI) at age 18 years and at study entry and weight change since age 18 years and colon cancer. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox regression.Results: During follow-up of 16,188 men and 23,438 women for 14 years on average, we ascertained 569 incident colon cancers. Weight and BMI at study entry were positively associated with colon cancer risk for men [HR, 1.12 (95% CI, 1.04-1.21) per 5-kg increment; HR, 1.39 (95% CI, 1.12-1.71) per 5 kg/m 2 ], but not

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Body Size, Weight Change, and Risk of Colon Cancer

Bassett

Severi

English

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Our study is consistent with previous studies in having shown stronger positive associations for BMI and colorectal cancer incidence [25][26][27][28][29][30][31][32] and adenoma recurrence, [18][19] in men compared with women. Studies of colorectal adenoma incidence have shown more equivocal results by sex, [33][34][35] though a meta-analysis of studies suggested that the association is weaker for postmenopausal women compared with premenopausal women.…”

Section: Discussionsupporting

confidence: 92%

Prospective Investigation of Body Mass Index, Colorectal Adenoma, and Colorectal Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Kitahara

Berndt

González

et al. 2013

JCO

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A B S T R A C T PurposeObesity has consistently been linked to an increased risk of colorectal cancer, particularly among men. Whether body mass index (BMI) differentially influences the risk across the stages of colorectal cancer development remains unclear. We evaluated the associations of BMI with colorectal adenoma incidence, adenoma recurrence, and cancer in the context of a large screening trial, in which cases and controls had an equal chance for disease detection. MethodsWe prospectively evaluated the association between baseline BMI and the risk of incident distal adenoma (1,213 cases), recurrent adenoma (752 cases), and incident colorectal cancer (966 cases) among men and women, ages 55 to 74 years, randomly assigned to receive flexible sigmoidoscopy screening as part of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We calculated odds ratios (ORs) and 95% CIs for adenoma incidence and recurrence, and hazard ratios (HRs) and 95% CIs for colorectal cancer incidence, using multivariable-adjusted models. ResultsCompared with normal-weight men (18.5 to 24.9 kg/m 2 ), obese men (Ն 30 kg/m 2 ) had significantly higher risk of incident adenoma (OR, 1.32; 95% CI, 1.06 to 1.65) and colorectal cancer (HR, 1.48; 95% CI, 1.16 to 1.89) and a borderline increased risk of recurrent adenoma (OR, 1.50; 95% CI, 0.98 to 2.30). No associations were observed for either adenoma or cancer in women. ConclusionData from this large prospective study suggest that obesity is important throughout the natural history of colorectal cancer, at least in men, and colorectal cancer prevention efforts should encourage the achievement and maintenance of a healthy body weight in addition to regular screenings.

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“…These associations seem to be stronger for men [1][2][3]. The 'Health Professionals Follow-Up Study' that included 46,349 men over a prospective 28-year period, the 'Melbourne Collaborative Cohort Study' with 16,188 men and 23,438 women with almost a 14-year follow-up, and the 'Norwegian population-based Study' of 8,822 men and 37,357 women corroborated these findings [4][5][6].…”

mentioning

confidence: 72%