A Prospective Study ofTrans-Fatty Acid Levels in Blood and Risk of Prostate Cancer

Chavarro, Jorge E.; Stampfer, Meir J.; Campos, Hannia; Kurth, Tobias; Willett, Walter C.; Ma, Jing

doi:10.1158/1055-9965.epi-07-0673

Cited by 74 publications

(63 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that TFAs are associated with increased risk of developing breast cancer and nonaggressive prostate cancer [21,22] . The effects of EA on colon carcinogenesis remain controversial.…”

Section: Discussionmentioning

confidence: 99%

Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

et al. 2016

View full text Add to dashboard Cite

The effects of trans-fatty acids (TFAs) on cardiovascular disorders have been extensively studied, and the effect of TFAs on cancers has recently been recognized. This study examined the effects of elaidic acid (EA), a TFA, on colorectal cancer (CRC) progression. We demonstrated that EA enhanced the growth, survival, and invasion of the CRC cell lines, CT26, and HT29. Tumor growth and metastasis in the lung, liver, and peritoneum were significantly more enhanced in CRC cells treated with EA than those treated with the cis form of EA, oleic acid (OA), or vehicle. Spheres of CRC cells were formed at more pronounced numbers in EA-treated cells than in OA-treated cells. Compared to OA, EA treatment also induced expression of the stemness factors, nucleostemin, CD133, and Oct4. Moreover, spheres of EA-treated CRC cells were larger and more proliferative than spheres of OA-treated cells. Oral intake of EA also enhanced liver metastasis and CD133 expression of CRC cells in a dose-dependent manner. EA intake also increased resistance to 5-fluorouracil. Inhibition of Wnt and ERK1/2 abrogated EA-induced enhancement of metastasis. Our findings demonstrate that EA might provide prominent metastatic potential to CRC cells, which shows important implications for the treatment of CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Among men with this genotype, the association between total trans FA, trans 18: 1, trans 18: 2 intake and PC was substantially stronger: ORs of higher quartiles equal to 4.80 (2.29-10.08), 5.11 (2.45-10.66) and 3.64 (1.65-8.08), respectively. In the study of Chavarro et al [2008], the effect is strong with a linear dose-dependent effect in subjects of the placebo arm with regard to trans 18: 2 and absent in the aspirin-treated subjects, suggesting an interference with the COX enzymes' pathway. These last 2 cohort studies in addition to the case-control study strongly suggested an increased risk of PC related to trans FA intake.…”

Section: Trans Fatty Acidsmentioning

confidence: 92%

“…The 3 case-control studies [Bidoli et al, 2005;Hedelin et al, 2007;Liu et al, 2007] and 5 cohort studies [Giovannucci et al, 2007;Neuhouser et al, 2007;Park et al, 2007;Wallström et al, 2007;Chavarro et al, 2007Chavarro et al, , 2008 reported conflicting results. Neither biological plausibility nor experimental models support a deleterious effect of ALA.…”

Section: N-3 Fa: Linolenic Acidmentioning

confidence: 99%

Background Review Paper on Total Fat, Fatty Acid Intake and Cancers

Gerber¹

2009

Ann Nutr Metab

View full text Add to dashboard Cite

“…The array of potentially harmful effects of industrial trans fatty acids is wide, and include alterations in metabolic and signalling pathways, higher circulating levels of lipid, systemic inflammation, endothelial dysfunction, and possibly increased visceral adiposity, body weight and insulin resistance [13]. There is evidence that trans fatty acids could be associated with an increased risk of breast cancer [14,15], non-aggressive prostate cancer [16], gastric adenocarcinomas [17] and colorectal adenomas [18]. The World Health Organisation recommends eliminating the use of trans fatty acids in food processing for cardiovascular disease prevention [19].…”

Section: Main Mechanisms Involving Nutritional Factors In Cancer Devementioning

confidence: 99%

European Code against Cancer 4th Edition: Diet and cancer

Norat

Scoccianti

Boutron‐Ruault

et al. 2015

Cancer Epidemiology

135

View full text Add to dashboard Cite

Lifestyle factors, including diet, have long been recognised as potentially important determinants of cancer risk. In addition to the significant role diet plays in affecting body fatness, a risk factor for several cancers, experimental studies have indicated that diet may influence the cancer process in several ways. Prospective studies have shown that dietary patterns characterised by higher intakes of fruits, vegetables, and whole-grain foods, and lower intakes of red and processed meats and salt, are related to reduced risks of death and cancer, and that a healthy diet can improve overall survival after diagnosis of breast and colorectal cancers. There is evidence that high intakes of fruit and vegetables may reduce the risk of cancers of the aerodigestive tract, and the evidence that dietary fibre protects against colorectal cancer is convincing. Red and processed meats increase the risk of colorectal cancer. Diets rich in high-calorie foods, such as fatty and sugary foods, may lead to increased calorie intake, thereby promoting obesity and leading to an increased risk of cancer. There is some evidence that sugary drinks are related to an increased risk of pancreatic cancer. Taking this evidence into account, the 4th edition of the European Code against Cancer recommends that people have a healthy diet to reduce their risk of cancer: they should eat plenty of whole grains, pulses, vegetables and fruits; limit high-calorie foods (foods high in sugar or fat); avoid sugary drinks and processed meat; and limit red meat and foods high in salt.

show abstract

A Prospective Study ofTrans-Fatty Acid Levels in Blood and Risk of Prostate Cancer

Cited by 74 publications

References 38 publications

Elaidic Acid, a <b><i>Trans</i></b>-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

Elaidic Acid, a <b><i>Trans</i></b>-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

Background Review Paper on Total Fat, Fatty Acid Intake and Cancers

European Code against Cancer 4th Edition: Diet and cancer

Contact Info

Product

Resources

About