A prospective study of serum C-reactive protein and D-lactate levels for early prediction of strangulation in intestinal obstruction

Dhoon, Ramprasad; Kumawat, Suresh; Soni, Murari Lal; Rohella, M. K.; Sharma, Sunil; Karosia, Vinod; Chahil, Rajesh

doi:10.18203/2349-2902.isj20192983

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…LPS can promote the synthesis and secretion of inflammatory factors and then induce systemic inflammation. As a specific and sensitive indicator of gastric mucosal ischemia, FABP can reflect the condition of gastric mucosal ischemia and damage [ 19 , 20 ]. Lin et al [ 21 ] used transnasal intestinal obstruction catheterization to treat acute intestinal obstruction caused by Yellowstone, which can significantly control the disease progression and relieve abdominal distention and pain.…”

Section: Discussionmentioning

confidence: 99%

Application Effect of Somatostatin Combined with Transnasal Ileus Catheterization in Patients with Acute Intestinal Obstruction and Advanced Gastric Cancer

Liu

2022

Computational Intelligence and Neuroscience

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Objective: To explore the application of somatostatin combined with nasal plug catheterization in patients with advanced gastric cancer and acute intestinal obstruction. Methods. This study included 94 cases of patients with acute intestinal obstruction and advanced gastric cancer, and according to the length of hospital stay, the patients were randomly divided into two groups: the control group and the study group, with 47 cases in each group. Based on the observations made by the team in the control group given somatostatin combined treatment, we observed two groups of patients with gastrointestinal function, serum index, quality of life, therapeutic effect, and adverse reactions. Results. Abdominal distention, abdominal pain duration, and normal exhaust time were significantly shorter in the study group than in the control group. The study group was higher than the control group in terms of gastrointestinal decompression volume, drainage volume, and abdominal circumference reduction within 24 hours ( P < 0.05 ). After treatment, the levels of CRP, IgA, LPS, and FABP were lower than before, and the levels of CRP, IgA, LPS, and FABP in the former group were much lower than those in the latter group ( P < 0.05 ). Compared with before treatment, the former GIQLI scale score was significantly higher than the latter ( P < 0.05 ). After treatment, the efficiency is much higher than the latter ( P < 0.05 ). After treatment, the former significantly lowers the incidence of postoperative complications of the latter ( P < 0.05 ). Conclusion. For patients with advanced gastric cancer and acute intestinal obstruction, it is safe and feasible to use somatostatin combined with transnasal intestinal obstruction catheterization to restore gastrointestinal function, improve inflammatory response, and promote the improvement of quality of life with high safety and feasibility.

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Section: Discussionmentioning

confidence: 99%

Application Effect of Somatostatin Combined with Transnasal Ileus Catheterization in Patients with Acute Intestinal Obstruction and Advanced Gastric Cancer

Liu

2022

Computational Intelligence and Neuroscience

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“…CRP begins to rise in 3-6 h after inflammation, peaks in 30-60 h 17 . Studies suggested that CRP and lactate levels might help predict strangulation and make early decisions for surgery 18 .…”

Section: Discussionmentioning

confidence: 99%

Do biomarkers have predictive value in the treatment modality of the patients diagnosed with bowel obstruction?

Şahin

Gülen

Acehan

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVES: This study aimed to investigate the ability of the biomarkers to predict the surgery treatment and mortality in patients above 18 years of age who were hospitalized with the diagnosis of bowel obstruction from the emergency department.METHODS: This is a 2-year retrospective study. The patients' demographic data, laboratory parameters on admission to emergency department, treatment modalities, and the length of hospital stay were recorded. Patients were divided into two groups: conservative and surgical treatment. Statistical analysis was performed to investigate the value of biomarkers in predicting mortality and the need for surgery. Data were analyzed using IBM SPSS version 22.RESULTS: A total of 179 patients were included in this study. Of these, 105 (58.7%) patients were treated conservative and 74 (41.3%) were treated operatively. The elevated procalcitonin (PCT) level, C-reactive protein, blood urea nitrogen-to-albumin ratio, and lactate-to-albumin ratio were significantly correlated with surgical treatment, length of hospital stay, and mortality. procalcitonin threshold value of 0.13 ng/mL was able to predict the need for surgical treatment, with a sensitivity of 79% and a specificity of 70.3%. Procalcitonin threshold value of 0.65 ng/mL was able to predict the mortality rate of the patients, with a sensitivity of 92.9% and a specificity of 78.1%.CONCLUSIONS: Biomarkers, especially procalcitonin, may be useful in bowel obstruction treatment management and may predict mortality.

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A Prospective Study on Lactate Dehydrogenase Levels in Acute Intestinal Obstruction as a Marker of Bowel Gangrene

Prathapan,

Walwekar,

Hosamani

et al. 2024

Cureus

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A prospective study of serum C-reactive protein and D-lactate levels for early prediction of strangulation in intestinal obstruction

Cited by 3 publications

References 8 publications

Application Effect of Somatostatin Combined with Transnasal Ileus Catheterization in Patients with Acute Intestinal Obstruction and Advanced Gastric Cancer

Application Effect of Somatostatin Combined with Transnasal Ileus Catheterization in Patients with Acute Intestinal Obstruction and Advanced Gastric Cancer

Do biomarkers have predictive value in the treatment modality of the patients diagnosed with bowel obstruction?

A Prospective Study on Lactate Dehydrogenase Levels in Acute Intestinal Obstruction as a Marker of Bowel Gangrene

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