A prospective study of viral and mycoplasma infections in chronic inflammatory bowel disease

Kangro, H. O.; Chong, Sonny K. F.; Hardiman, Annarella; Heath, R. B.; Walker-Smith, J A

doi:10.1016/0016-5085(90)90272-3

Cited by 102 publications

(49 citation statements)

References 9 publications

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“…In particular, during the winter, due to respiratory tract infections with organisms such as influenza and Mycoplasma pneumoniae, these drugs may be associated with the onset of UC. It has also been reported that respiratory and systemic viral infections are associated with the exacerbation of inflammatory bowel disease [23,24] . Also during the winter, intake of NSAIDs due to arthritic pain is common in Japan.…”

Section: Discussionmentioning

confidence: 98%

Seasonal variations in the onset of ulcerative colitis in Japan

Koido

Ohkusa

Saito

et al. 2013

WJG

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AIM:To investigate seasonal variations in the onset and relapse of ulcerative colitis (UC) in Japanese patients. Between 1994 and 2006, 198 Japanese patients diagnosed with UC according to conventional criteria in an academic hospital were enrolled for onset evaluation. Among 265 Japanese patients with UC who were observed for more than 12 mo, 165 patients relapsed (239 times) and were enrolled for relapse evaluation. The patients' symptoms were recorded each month for 12 consecutive years. METHODS: BRIEF ARTICLE RESULTS:There was monthly seasonality in symptom onset during October and March for UC. The onset of symptoms in UC patients frequently occurred during the winter. Variation in UC onset was observed according to both month (P = 0.015) and season (P = 0.048). Relapse commonly occurred in October, and variations in relapse were not significant either in month (P = 0.52) or season (P = 0.12). Upper respiratory inflammation was the main factor responsible for relapse. CONCLUSION:Our results suggest that environmental factors associated with winter and spring seasonality may be responsible for triggering the clinical onset of UC in Japan.© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Japanese population; Onset; Relapse; Seasonal variations; Ulcerative colitisCore tip: Monthly seasonality in the symptomatic onset of ulcerative colitis (UC) during October and March was observed in Japan. The onset of symptoms frequently occurred during the winter, whereas relapse of UC particularly occurred in October. Upper respiratory inflammation was one of the main factors responsible for relapse. Therefore, environmental factors associated with winter and spring seasonality may be responsible for triggering the clinical onset of UC in Japan.

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Section: Discussionmentioning

confidence: 98%

Seasonal variations in the onset of ulcerative colitis in Japan

Koido

Ohkusa

Saito

et al. 2013

WJG

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“…Studies investigating seasonal patterns in the onset or reactivation of these diseases have produced conflicting results [1,2,3,4,5,6,7,8,9,10,11,12]. Most were retrospective, based on records from specialist outpatient clinics or general practitioners, and checked relapses after treatment with the drugs usually used during flare-ups, such as steroids.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Patterns of Hospital Treatment for Inflammatory Bowel Disease in Italy

Soncini

Triossi²,

P³

et al. 2006

Digestion

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Aim: It is still debated whether clinical flare-ups of chronic inflammatory bowel disease follow a seasonal pattern, and the various reports are based on general practitioners’ records or hospital discharge charts. There are, however, no specific figures for treatment in hospital gastroenterology units, which serve as a reference point for these disorders. This study was therefore designed to investigate whether there is a seasonal pattern in admissions for inflammatory intestinal disease in Italy, differing from what is generally known about gastrointestinal pathologies, since there are no nation-wide figures on the subject. Methods: The RING (Ricerca Informatizzata in Gastroenterologia) project is an observational study collecting hospital discharge forms from 22 centers in Italy. Results: From winter 2000 to autumn 2003, the 22 gastroenterology units participating in the RING project discharged 32,357 patients following ordinary hospital admissions. Of these, 2,856 (8.8%) had a main diagnosis of inflammatory bowel disease: 1,541 Crohn’s disease, and 1,315 ulcerative colitis. No seasonal patterns were detected for either category, or when the analysis was done by age, sex and site of disease. Conclusions: The most serious flare-ups of inflammatory bowel disease, i.e. those requiring routine hospital treatment, do not appear to follow any seasonal pattern, regardless of the site of the disease or the patient’s age or sex.

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“…In an extensive study, Kangro et al (5) reported that 40% of disease flares in a population of susceptible individuals were temporally associated with documented viral respiratory infections. Other groups have demonstrated a higher incidence of measles virus particles in the resected colon tissue of patients with Crohn's disease as compared with tissue from patients who did not have IBD (6,7).…”

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confidence: 99%