2019
DOI: 10.3390/nu11071596
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A Prospective Study on Changes in Nutritional Status and Growth Following Two Years of Ketogenic Diet (KD) Therapy in Children with Refractory Epilepsy

Abstract: Introduction: Epilepsy is a neurological disorder characterized by an increased susceptibility to seizures. The ketogenic diet (KD) is currently the most important alternative non-pharmacological treatment. Despite its long history of clinical use, it is not clear how this diet affects longitudinal growth in children. Methods: A prospective study was designed to evaluate growth and nutritional status in 45 children on KD. Growth was assessed by measuring weight, height, and body mass index (BMI). Standard devi… Show more

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Cited by 27 publications
(21 citation statements)
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“…Other studies, specifically those that do not require a calorie restriction and provide vitamin and mineral supplementation, do not report such significant impacts on growth [ 63 , 107 ]. A prospective cohort of 151 children with refractory epilepsy were followed to evaluate growth as well as nutritional status on the cKD [ 109 ]. Participants in this cohort were not calorie restricted, received 90% of energy from fat and 10% of energy from protein plus carbohydrate and a sugar-free multivitamin, calcium and potassium citrate as oral supplementation.…”
Section: Resultsmentioning
confidence: 99%
“…Other studies, specifically those that do not require a calorie restriction and provide vitamin and mineral supplementation, do not report such significant impacts on growth [ 63 , 107 ]. A prospective cohort of 151 children with refractory epilepsy were followed to evaluate growth as well as nutritional status on the cKD [ 109 ]. Participants in this cohort were not calorie restricted, received 90% of energy from fat and 10% of energy from protein plus carbohydrate and a sugar-free multivitamin, calcium and potassium citrate as oral supplementation.…”
Section: Resultsmentioning
confidence: 99%
“…Ferraris and co-authors [ 43 ] retrospectively investigated the occurrence of linear growth retardation in 34 children on a KDT, 20 of them with GLUT1DS, of which 16 did not show growth retardation at 12 months. A prospective study was designed by Armeno et al [ 48 ] to evaluate growth in 45 children on a KDT. They observed growth deceleration in 9%.…”
Section: Discussionmentioning
confidence: 99%
“…The nutritional follow-up was helpful to improve overweight and thinness, but showed growth deceleration in some of the subjects, confirming that children with refractory epilepsy treated with KD need careful growth monitoring. However, as was also declared by the authors themselves, several limiting problems affected the data interpretation of the study: (a) the lack of consideration of other causes of delayed growth, as represented by different antiepileptic drugs, type of epileptic syndrome, or severity of neurologic dysfunction; (b) the lack of addressing the association between height velocity and hormonal growth status before starting and while on KD [ 121 ].…”
Section: How Could Kds and Kbs Affect Bone Metabolism?mentioning
confidence: 99%
“…Subjects on the KD showed a delay in growth Fourthy-five Argentinian children, 23 boys, on KD for at least two years, between 0.8 and 17.3 years of age (mean 6.6) [121] Prospective cohort Growth assessment (weight, height, and BMI). Standard deviation scores for all measurements calculated at KD initiation and at follow-up…”
Section: Duration Of the Kd Regimen And Study Of Bone Health Parametersmentioning
confidence: 99%