A Prospective Study on Mother-to-Infant Transmission of Hepatitis C Virus

Zanetti, Alessandro; Tanzi, Elisabetta; Romanò, Luisa; Decorti, Giuliana; Minola, E.; Vecchi, L.; Principi, Nicola

doi:10.1159/000024938

Cited by 98 publications

(65 citation statements)

References 13 publications

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“…The present data contribute to our understanding of the epidemiology of MTCT of HCV among HIV-coinfected mothers in Latin America and the Caribbean [42,[53][54][55][56][57]. Most infants who are chronically infected with HCV will initially have asymptomatic infections without significant liver disease.…”

Section: Discussionmentioning

confidence: 99%

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Cabot

Stoszek

Quarleri

et al. 2012

Journal of the Pediatric Infectious Diseases Society

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Background. Maternal human immunodeficiency virus (HIV) coinfection has been associated with increased hepatitis C virus (HCV) mother-to-child transmission (MTCT). We hypothesized that HCV/HIVcoinfected women with well-controlled HIV disease would not have increased HCV MTCT. Methods. The NISDI Perinatal and LILAC cohorts enrolled HIV-infected pregnant women and their infants in Latin America and the Caribbean. This substudy evaluated the HCV infection status of mothers at participating sites and their live born, singleton infants who had a 6-month postnatal visit by December 31, 2008. Mothers who were anti-HCV-positive, or who had CD4 counts (cells/mm 3 ) <200 with detectable HCV RNA, were considered HCV-infected. All HCV-infected women were tested for HCV RNA. Infants with HCV RNA were considered HCV-infected. Results. Of 1042 enrolled women, 739 (71%) mother-infant pairs met the inclusion criteria. Of the 739 women, 67 (9%) were anti-HCV-positive and 672 anti-HCV-negative [68 (10%) with CD4 counts <200; of these, 3 (4.4%) were HCV RNA-positive]. Therefore, our study population comprised 70 HCV-infected (47 with HCV RNA) and 669 HCV-uninfected women (and their infants). Factors associated with maternal HCV infection included unemployment (odds ratio [OR] = 2.58

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Section: Discussionmentioning

confidence: 99%

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Cabot

Stoszek

Quarleri

et al. 2012

Journal of the Pediatric Infectious Diseases Society

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“…The corresponding crude and weighted mother-to-infant transmission rates for women who did not report a history of IVDU was 4.2% (SD ϭ 1.1%) and 3.4%, respectively. 20,25,27,[30][31][32] …”

Section: Intravenous Drug Usementioning

confidence: 99%

Mother–To–Infant Transmission of Hepatitis C Virus

2001

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“…Em pesquisa de gestantes infectadas pelo VHC, não houve transmissão vertical em mães contaminadas apenas com o VHC; contudo, esta percentagem atinge índices de até 36% nos casos de coinfecção pelo HIV 20 . Outro estudo descreve taxa de TV de 3,2% em pacientes não-coinfectadas pelo HIV e 22,5% em pacientes infectadas pelos dois vírus 21 . Metanálise incluindo 10 estudos e 2.382 crianças nascidas de mães infectadas por VHC, com ou sem coinfecção por HIV, demonstrou que a coinfecção estava associada à elevação de 2,8 vezes no risco de TV do VHC 17 .…”

Section: Introductionunclassified

Hepatite C e gestação: análise de fatores associados à transmissão vertical

Gardenal¹,

Figueiró-Filho

Luft

et al. 2011

Rev. Soc. Bras. Med. Trop.

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RESUMOIntrodução: Informações sobre hepatite C durante a gestação em serviços brasileiros são escassas. O objetivo deste estudo foi verificar os fatores associados à transmissão vertical do vírus da hepatite C em gestantes. Métodos: Estudo observacional, transversal, realizado em gestantes procedentes do município de Campo Grande/MS, que apresentaram sorologia reagente e confirmada para VHC, no período de 2002 a 2005. Considerou-se transmissão vertical sorologia VHC positiva por ELISA, confirmada com PCR, após os 18 meses de vida do recém-nascido. Considerou-se fatores associados a TV: tipo de parto, tempo de rotura de membranas, amamentação, histórico de transfusões sanguíneas prévias, uso de drogas ilícitas, número de parceiros sexuais e presença de tatuagens pelo corpo. Resultados: Identificou-se 58 gestantes portadoras do VHC, revelando prevalência de infecção de 0,2% (58/31.187). Das 58 pacientes, 23 (39,6%) preencheram os critérios de inclusão no estudo. A taxa de TV foi de 13% (3/23), sendo os subtipos virais mais frequentes: 1a (53%), 1b (30%), 2b (4%) e 3a (13%). Duas (8,7%) pacientes apresentaram co-infecção pelo HIV. Houve associação (p < 0,05) entre TV e carga viral elevada (> 2,5x10 6 ) e entre TV e uso de drogas ilícitas pela mãe (p < 0,05). Conclusões: O presente estudo demonstra que elevada viremia materna e o uso de drogas ilícitas pela mãe associam-se a transmissão materno-fetal do VHC. Vertical transmission was considered to be positive HCV serology by ELISA, confirmed by PCR, after 18 months of life of the newborn. The factors studied associated with VT were: delivery mode, time of premature rupture of membranes, breastfeeding, blood transfusion history, drug addiction, number of sexual partners and the presence of body tattoos. Results: Fifty-eight pregnant women with HCV infection were identified, indicating a prevalence rate of 0.2% (58/31,187). Of these 58 pregnant women, 23 (39.6%) fulfilled the inclusion criteria. The VT rate was 13% (3/23), and the most frequent HCV viral subtypes were 1a (53%), 1b (30%), 2b (4%) e 3a (13.0%). Two (8.7%) patients were coinfected with HIV. A significant association (p < 0.05) was observed between VT and high maternal serum viremia (> 2.5x10 Palavras-chaves:

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A Prospective Study on Mother-to-Infant Transmission of Hepatitis C Virus

Cited by 98 publications

References 13 publications

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Mother–To–Infant Transmission of Hepatitis C Virus

Hepatite C e gestação: análise de fatores associados à transmissão vertical

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