A prospective study to assess the role of vitamin D individually and in combination with cyclosporine in the treatment of dry eye in patients with deficient serum 25(OH)D levels

Watts, P. S.; Sahai, Anshu; Kumar, P Ratan; Shamshad, Mohd Abid; Trivedi, Gopal Krishan; Tyagi, Lokendra

doi:10.4103/ijo.ijo_1492_19

Cited by 20 publications

(24 citation statements)

References 31 publications

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“…These are in agreement with findings, of Bae et al (11) which concluded that the mean age of the patients was 58.21 ± 12.94 years and included 21 men and 84 women. In another prospective-randomized study of Watts et al (12) in which 90 patients with DED with deficient serum 25(OH) D levels were randomized into three groups and were given treatment for dry eye. Out of 90 patients, 52 were females and 38 were males with a mean age of 44.87 ± 14.77 (range = 20-80) years.…”

Section: Discussionmentioning

confidence: 99%

“…Among the many etiological factors, an association of Vitamin D deficiency with DES and tear film insufficiency has received attention in recent studies. The prevalence of vitamin D deficiency in India has been reported to be 80%-90% in most studies (13) , a study of Watts et al (12) and Aparna et al (14) defined the deficiency as a serum vitamin D level of < 20 ng/ml. However, another study of Yoon et al (15) has taken < 12 ng/ml as the cutoff.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Vitamin D Supplementation on Dry Eye in People with Low Serum Vitamin D

Said¹,

Basiony²,

Amin³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Dry eye is a disease (DED) of the tear film and ocular surface, leading to ocular discomforts and pain. The pathophysiology of DED includes tear film instability and ocular surface inflammation. Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate, and zinc. It is not strictly a vitamin, and may be considered a hormone as its synthesis and activity occur in different locations.Objective: This study aimed to investigate tear film function in patients with vitamin D deficiency. Patient and methods: A case-control study included 75 eyes of 39 patients who were referred to the Ophthalmologic Clinic, Menoufia University during the period from March 2020 to December 2020. Patients of dry eye underwent tear break up time, Schirmer I test without anesthesia and special tests as well as measurement of serum vitamin D level were assessed. Results: 25-hydroxy vitamin D level of the studied group ranged from 6-18.50 ng/ml with mean value of 8.22 ± 4.814 ng/ml. Also, majority of studied sample (92.3%) had bilateral affected eyes, followed by Gelinya (30%). Schirmer's test, tear film breakup time (TFBUT) and ocular surface disease index (OSDI) were increased significantly when compared the values at baseline and after treatment to be after 10 weeks (P < 0.001). Conclusion:Vitamin D replacement appears to improve ocular surface health in patients with vitamin D deficiency. However, further clinical trials with a large sample size and control group are warranted to define the role of vitamin D. Vitamin D supplementation is an effective and useful treatment for patients with dry eye syndrome (DES) that is refractory to conventional treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D Supplementation on Dry Eye in People with Low Serum Vitamin D

Said¹,

Basiony²,

Amin³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…An improvement in cornea epithelial bore has been reported in patients with vitamin D supplementation, because it regulates narrow joints between cells 10 . In addition, vitamin D immunomodulatory mechanisms have been proposed in in ammatory eye processes, expressed in inhibition of in ammatory cell migration (Th1 and Th2 cells), increased interleucine synthesis (IL) 10, reduction of in ammatory cytokines such as IL6, C-reactive protein and tumor necrosis factor (TNF) alpha 11,12 . Other described functions of this vitamin is act as a stabilizer of the eye surface, through the reduction of the osmolarity of tears 12 .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Role in Chronic Dacryocystitis

Valentín-Bravo¹,

Onrubia²,

Pacheco-Callirgos³

et al. 2021

Preprint

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Introduction: Vitamin D deficiency has been associated with dry eye disease or Sjogren's syndrome. Due to the anti-inflammatory role of vitamin D in eye diseases, it has been proposed to study the role of this vitamin in chronic dacryocystitis, which is an infectious and inflammatory process affecting the nasolacrimal system. Objective: Determine the association between vitamin D levels with the presence of chronic dacryocystititis.Materials and Methods: A cross-sectional descriptive observational study analyzed a sample of 40 individuals, of whom had been diagnosed with chronic dacryocystitis. Biochemical tests for serum 25-hydroxyvitamin D (vitamin D) were subjected to the entire sample. The difference in the means was calculated using the T-test for associated data. The reference significance value was 0.05.Results: Chronic dacryocystitis commonly occurs in the age group of 51 to 67 years. Women were more vulnerable to infection than men. No association was found between the presence of chronic dacriocystitis and vitamin D levels (p-0.755). It is recommended to use larger cohorts as well as multicenter studies evaluating this association, such as supplemental use of vitamin D on a large scale.Conclusions: Low vitamin D levels are not associated with the presence of chronic dacriocystitis.

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“…published in this issue of the Indian Journal of Ophthalmology. [ 1 2 3 4 ] The prevalence of vitamin D deficiency in India has been reported to be 40%–99% (80%–90% in most studies). [ 5 ] Most studies define the deficiency as a serum vitamin D level of <20 ng/ml;[ 4 5 ] however, some studies[ 2 ] have taken <12 ng/ml as the cutoff.…”

mentioning

confidence: 99%

“…[ 6 ] Vitamin D induces the production of IL10 and reduces inflammatory cytokines/factors like IL1, IL6, TNF alpha, and C-reactive protein. [ 4 ] In addition, vitamin D reduces inflammation by increasing antioxidant cytokines in tears and suppressing both Th1 and Th2 cells. [ 7 ] Vitamin D induces D cathelicidin, which promotes the wound healing of conjunctiva and cornea.…”

mentioning

confidence: 99%