A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice

Weerachayaphorn, Jittima; Chuncharunee, Aporn; Mahagita, Chitrawina; Lewchalermwongse, Buarong; Suksamrarn, Apichart; Piyachaturawat, Pawinee

doi:10.1016/j.jep.2011.06.040

Cited by 34 publications

(18 citation statements)

References 43 publications

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“…Previously, our group has shown that ASPP 049 is the major phytoestrogen found in C. comosa and that the hexane extract of C. comosa protected bone loss in ovariectomized mice (14,15). Our data, therefore, provide evidence suggesting that ASPP 049 may prevent bone loss by activating Wnt/␤-catenin signaling as E2 does (5).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we have demonstrated that the hexane extract of C. comosa prevents bone loss induced by estrogen deficiency in a mouse model (14). To test whether ASPP 049 activates Wnt signaling in bone cells as in transfected HEK 293T cells, we examined the effects of this compound and E2 on endogenous Wnt/␤-catenin signaling in preosteoblastic cells (MC3T3-E1).…”

Section: Aspp 049 Induces Tcf/lef-dependent Activation Of Wnt/␤-catenmentioning

confidence: 99%

“…C. comosa exhibits an estrogen-like activity and induces cornification of the vaginal epithelium in the smear and keratinization of the mucosal surface of the vagina (13). Recently, a study reported that the hexane extract of this plant prevented bone loss induced by estrogen deficiency (14). However, the molecular mechanism underlying the effect of C. comosa in protecting bone loss is still unknown.…”

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confidence: 99%

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A Phytoestrogen Diarylheptanoid Mediates Estrogen Receptor/Akt/Glycogen Synthase Kinase 3β Protein-dependent Activation of the Wnt/β-Catenin Signaling Pathway

Bhukhai

Suksen

Bhummaphan

et al. 2012

Journal of Biological Chemistry

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Background: Diarylheptanoid (ASPP 049) isolated from C. comosa exhibits high estrogenic activity. Results: ASPP 049 rapidly induced ␤-catenin accumulation in the nucleus and activated TCF/LEF-mediated activation of Wnt/␤-catenin signaling. Conclusion: ASPP 049 from C. comosa induces preosteoblastic cell proliferation and differentiation through activation of Wnt/␤-catenin signaling. Significance: Providing a scientific rationale for using C. comosa as a dietary supplement to prevent bone loss in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Section: Aspp 049 Induces Tcf/lef-dependent Activation Of Wnt/␤-catenmentioning

confidence: 99%

mentioning

confidence: 99%

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A Phytoestrogen Diarylheptanoid Mediates Estrogen Receptor/Akt/Glycogen Synthase Kinase 3β Protein-dependent Activation of the Wnt/β-Catenin Signaling Pathway

Bhukhai

Suksen

Bhummaphan

et al. 2012

Journal of Biological Chemistry

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“…Based on previous experimental studies, oral administration of plant extracts should begin right after OVX, especially for phytoestrogens with mild estrogenic action, due to the fact that changes in proximal tibia post OVX are clearly evident in 2 weeks time [15,28,29,33]. The beneficial effect of AP extract on the prevention of bone loss and maintenance of bone strength after ovariectomy might be related to the presence of different types of isoflavonoids included in it.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Patsaki¹,

Tchoumtchoua²,

Passali³

et al. 2016

Med Aromat Plants

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“…The hexane extract of C. comosa rhizome exhibited hypocholesterolemic [14,15] and anti-inflammatory activity [16,17]. Furthermore, treatment with C. comosa hexane extract improved the spatial memory of post-training [18] and effectively prevented bone loss in ovariectomized rodents [19]. The unique pharmacological actions of C. comosa underscore its therapeutic potential in relieving menopausal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Improvements of insulin resistance in ovariectomized rats by a novel phytoestrogen from Curcuma comosa Roxb

Prasannarong

Saengsirisuwan

Piyachaturawat

et al. 2012

BMC Complement Altern Med

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BackgroundCurcuma comosa Roxb. (C. comosa) is an indigenous medicinal herb that has been used in Thailand as a dietary supplement to relieve postmenopausal symptoms. Recently, a novel phytoestrogen, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol or compound 049, has been isolated and no study thus far has investigated the role of C. comosa in preventing metabolic alterations occurring in estrogen-deprived state. The present study investigated the long-term effects (12 weeks) of C. comosa hexane extract and compound 049 on insulin resistance in prolonged estrogen-deprived rats.MethodsFemale Sprague-Dawley rats were ovariectomized (OVX) and treated with C. comosa hexane extract (125 mg, 250 mg, or 500 mg/kg body weight (BW)) and compound 049 (50 mg/kg BW) intraperitoneally three times per week for 12 weeks. Body weight, food intake, visceral fat weight, uterine weight, serum lipid profile, glucose tolerance, insulin action on skeletal muscle glucose transport activity, and GLUT-4 protein expression were determined.ResultsProlonged ovariectomy resulted in dyslipidemia, impaired glucose tolerance and insulin-stimulated skeletal muscle glucose transport, as compared to SHAM. Treatment with C. comosa hexane extract and compound 049, three times per week for 12 weeks, markedly reduced serum total cholesterol and low-density lipoprotein levels, improved insulin sensitivity and partially restored uterine weights in ovariectomized rats. In addition, compound 049 or high doses of C. comosa hexane extract enhanced insulin-mediated glucose uptake in skeletal muscle and increased muscle GLUT-4 protein levels.ConclusionsTreatment with C. comosa and its diarylheptanoid derivative improved glucose and lipid metabolism in estrogen-deprived rats, supporting the traditional use of this natural phytoestrogen as a strategy for relieving insulin resistance and its related metabolic defects in postmenopausal women.

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A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice

Cited by 34 publications

References 43 publications

A Phytoestrogen Diarylheptanoid Mediates Estrogen Receptor/Akt/Glycogen Synthase Kinase 3β Protein-dependent Activation of the Wnt/β-Catenin Signaling Pathway

A Phytoestrogen Diarylheptanoid Mediates Estrogen Receptor/Akt/Glycogen Synthase Kinase 3β Protein-dependent Activation of the Wnt/β-Catenin Signaling Pathway

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Improvements of insulin resistance in ovariectomized rats by a novel phytoestrogen from Curcuma comosa Roxb

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