“…QL migrates posteriorly, differentiating into PQR, PVM, and SDQL neurons (Figures 1A and 1B), whereas QR migrates anteriorly, producing AQR, AVM, and SDQR neurons. Q neuroblast migration is activated by EGL-20/Wnt proteins secreted posteriorly (Coudreuse et al, 2006), a process mediated through the endocytosis of Wnt-transport factor MIG-14/Wls by Retromer complex as well as proper folding by protein disulfide isomerase (PDI-1) (Coudreuse et al, 2006;Pan et al, 2008;Torpe et al, 2019;Yang et al, 2008). Binding of EGL-20/Wnt to the Frizzled receptors LIN-17 and MIG-1 in the QL leads to the activation of the canonical Wnt signaling with BAR-1/b-catenin stabilization and nuclear localization (Harris et al, 1996;Maloof et al, 1999;Sawa et al, 1996), which induces the transcription of target genes, including mab-5 (Harris et al, 1996;Salser and Kenyon, 1992;Whangbo and Kenyon, 1999).…”