A proteomic analysis of the anti-dengue virus activity of andrographolide

Paemanee, Atchara; Hitakarun, Atitaya; Wintachai, Phitchayapak; Roytrakul, Sittiruk; Smith, Duncan R.

doi:10.1016/j.biopha.2018.10.054

Cited by 56 publications

(46 citation statements)

References 45 publications

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“…Andrographolide, a bicyclic diterpenoid lactone, is a major bioactive constituent of Andrographis paniculata, and has been shown to have activity against a number of viruses including DENV [16][17][18][19][20][21][22][23][29][30][31]. Given the close relationship between DENV and ZIKV, which belong to the same genus, it seems reasonable to expect that andrographolide would have antiviral activity against ZIKV, as was Figure 6.…”

Section: Discussionmentioning

confidence: 91%

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Khanom

Sun

et al. 2020

Molecules

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Andrographolide is a labdene diterpenoid with potential applications against a number of viruses, including the mosquito-transmitted dengue virus (DENV). In this study, we evaluated the anti-viral activity of three 14-aryloxy analogues (ZAD-1 to ZAD-3) of andrographolide against Zika virus (ZIKV) and DENV. Interestingly, one analogue, ZAD-1, showed better activity against both ZIKV and DENV than the parental andrographolide. A two-dimension (2D) proteomic analysis of human A549 cells treated with ZAD-1 compared to cells treated with andrographolide identified four differentially expressed proteins (heat shock 70 kDa protein 1 (HSPA1A), phosphoglycerate kinase 1 (PGK1), transketolase (TKT) and GTP-binding nuclear protein Ran (Ran)). Western blot analysis confirmed that ZAD-1 treatment downregulated expression of HSPA1A and upregulated expression of PGK1 as compared to andrographolide treatment. These results suggest that 14-aryloxy analogues of andrographolide have the potential for further development as anti-DENV and anti-ZIKV agents.

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Section: Discussionmentioning

confidence: 91%

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Khanom

Sun

et al. 2020

Molecules

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“…However, in adult animals, GRP78 is preferably required for cancer cell survival under pathological conditions such as tumor progression and drug resistance (Wang, Wey, Zhang, Ye, & Lee, 2009). Furthermore, andrographolide was also shown to act against DENV through GRP78 interaction pathway (Paemanee et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Results highlighted the important role of GRP78 and the unfolded protein response in mediating the anti-DENV activity of andrographolide; this might explain the broad antiviral activity of andrographolide (Paemanee, Hitakarun, Wintachai, Roytrakul, & Smith, 2019).…”

Section: Anti-denv Effects Of Diterpenes And/or Their Derivativesmentioning

confidence: 91%

“…A very recent study was conducted in an attempt to further understand the mechanism of action of andrographolide in inhibiting DENV infection of liver cells using a proteomic based approach. Results highlighted the important role of GRP78 and the unfolded protein response in mediating the anti‐DENV activity of andrographolide; this might explain the broad antiviral activity of andrographolide (Paemanee, Hitakarun, Wintachai, Roytrakul, & Smith, ).…”

Section: Review Findingsmentioning

confidence: 93%

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Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

Islam

Mubarak

2019

Phytotherapy Research

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Dengue, a mosquito‐borne viral disease, causes about 100 million cases of infection annually. It is a major public concern, and if left untreated or improperly diagnosed, may cause serious health problems or even death. Historically, dengue has not considered priorities for pharmaceutical companies made the available treatment options. Therefore, medicinal scientists are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Diterpenes, a class of terpenes have gained much attention due to their diverse biological effects. This review aimed at summarizing available evidences of diterpenes and their derivatives acting against dengue virus and their vectors. For this, an updated search was made in the databases: PubMed and ScienceDirect by using specific keywords. Among the 117 published reports, a total of 30 articles was included in this review. Findings suggest that a number of diterpenes and/or their derivatives act against dengue virus and their two potential vectors namely Aedes aegypti and Ae. albopictus. In conclusion, diterpenes and their derivatives may have the potential alternative therapeutic tools for the management of dengue virus and some associated diseases transmitted by Aedes mosquito.

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“…It is a lactone diterpene that gives the plant a bitter taste. Many studies have focused on the anti-viral [12][13][14], anti-thrombotic [15,16], hepatoprotective [17,18], anticancer [19,20], and anti-inflammatory properties [21] of andrographolide. Several data have reported the antioxidant activities of andrographolide in various in vitro and in vivo model systems [22,23].…”

Section: Introductionmentioning

confidence: 99%

Andrographolide, A Natural Antioxidant: An Update

et al. 2019

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Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

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A proteomic analysis of the anti-dengue virus activity of andrographolide

Cited by 56 publications

References 45 publications

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

Andrographolide, A Natural Antioxidant: An Update

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