A Prototype Prophylactic Anti-Influenza Preparation in Aerosol Form on the Basis ofAbies sibiricaPolyprenols

Abstract

This research investigates a promising antiviral compound based on polyprenols from Siberian silver fir (Abies sibirica). The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 microm; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD(50) of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 microg/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities.

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

“…Apart from that, there are several studies that examine polyisoprenoid-containing bilayer lipid membrane models [35][36][37] and liposomal formulations [38]. All the accumulated research notwithstanding, there are still only a few commercial polyprenol formulations such as Ropren ® [39], Fortepren ® [3], and antiviral polyprenol aerosol [40] available on the market today, and thus we wished to explore the potential of such polyprenol preparations further.…”

Cytotoxic and Antiproliferative Activity of Polyisoprenoids in Seventeen Mangroves Species Against WiDr Colon Cancer Cells

“…There are two types of polyisoprenoids:the first is polyprenol, and the second is dolichol. Polyisoprenoids are not toxic, and polyisoprenoids are known to show some pharmacological activity, as anticancer (Kuznecovs et al, 2007), antidyslipidaemic (Singh et al, 2007), anti-influenza, and antiviral agents (Safatov et al, 2005).…”

Polyprenols from Taxus chinensis var. mairei prevent the development of CCl4-induced liver fibrosis in rats

“…mairei. Polyprenols have anticancer (Kuznecovs et al, 2007), antidyslipidemic (Singh et al, 2007), anti-influenza and antiviral activities (Safatov et al, 2005). Several studies have demonstrated the hepatoprotective effects of polyprenols on patients with non-alcoholic steatohepatitis (Golovanova et al, 2010) and with acute or chronic hepatic injury induced by carbon tetrachloride (CCl 4 ) (Wang et al, 2008;Yang et al, 2011).…”