A Pulmonary Sclerosing Hemagioma with an Increasing Uptake on PET

Abstract

Pulmonary sclerosing hemangioma is a relatively rare neoplasm of the lung. Although there have been five previous case reports that address the 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) findings in a sclerosing hemangioma of the lung, no report has demonstrated an interval change in the FDG-PET findings. This report describes a case of pulmonary sclerosing hemangioma which presented with an increase of uptake of FDG-PET after about one years' follow-up.

18F-FDG PET/CT features of pulmonary sclerosing hemangioma

“…A total of 16 PSHs from 10 reports were found, and their 18F-FDG PET or PET/CT features were summarized in Table 3. Except for two cases of PSH (11), of which the SUVmax was 0, PSHs have been reported to show various increased FDG uptakes and SUVmax, which ranged 1.6 to 5.3 (4,(11)(12)(13)(14)(15)(16)(17)(18)(19). The results of these previous reported cases were similar to those of our study.…”

“…Based on our results and previous case reports (4,(11)(12)(13)(14)(15)(16)(17)(18)(19), we can state that PSHs often show increased FDG uptake and significant SUVmax, particularly when they are 2 cm or larger even though it is benign in pathology and clinical course. On the other hand, this increased FDG uptake of PSH may be evidence of low-grade malignancy to some investigators who regard this tumor as a potentially lowgrade malignancy since a few cases of lymph node metastases have been reported (17 -23).…”

Treatment of 28 patients with sclerosing hemangioma (SH) of the lung

“…But in fact, FDG is not a cancer-specific agent and some benign diseases including SH could show false-positive results on PET [11]. There have been some published reports about pulmonary SH with increased uptake on PET scan, and some authors thought the high uptake should be related to the tumor size or the potentially low-grade malignant nature of SH [12-15]. We performed PET scan on five patients, and found SUV of the patient who had bilateral multiple tumors and the largest tumor of the patient was 5.5 cm in diameter was greater than 2.5.…”

18F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography and Computed Tomography in a Large Pulmonary Sclerosing Pneumocytoma with Contralateral Lung Metastasis

“…[ 5 ] 18 F-FDG PET/CT has been used in the evaluation of these tumors with different studies depicting a highly variable 18 F-FDG uptake. [ 6 7 8 9 ] To the best of our knowledge, this is the largest PSP reported till now in the literature. PSP is a benign slow-growing tumor, but rare occurrences of metastases warrant long-term follow-up.…”