A pulse radiolysis study of hyperoside isolated from Hypericum mysorense

Hariharapura, Raghu Chandrashekar; Mahal, H. S.; Ramamurthy, Srinivasan; Jagani, Hitesh; Vijayan, P.

doi:10.1016/j.radphyschem.2014.09.011

Cited by 7 publications

(4 citation statements)

References 54 publications

(62 reference statements)

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“…Technically, O 2 •– can be generated from O 2 by using various methods such as sonolysis − and pulse radiolysis. − Pulse radiolysis provides a well-defined solution and high O 2 •– concentrations in the presence of specific radical-scavenging substances. It is widely used in biological studies, − particularly for studying the reaction mechanisms of O 2 •– with enzymes, namely, SODs and superoxide reductases. − However, specialized equipment is required. − Moreover, because O 2 •– is a short-lived species in aqueous solutions, it decomposes immediately following pulse radiolysis. Therefore, this method is unsuitable for studying the long-term reactivity of O 2 •– .…”

Section: Generation Of the Superoxide Ionmentioning

confidence: 99%

Superoxide Ion: Generation and Chemical Implications

Hayyan¹,

Hashim²,

AlNashef³

2016

Chem. Rev.

1,713

1,058

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Superoxide ion (O2(•-)) is of great significance as a radical species implicated in diverse chemical and biological systems. However, the chemistry knowledge of O2(•-) is rather scarce. In addition, numerous studies on O2(•-) were conducted within the latter half of the 20th century. Therefore, the current advancement in technology and instrumentation will certainly provide better insights into mechanisms and products of O2(•-) reactions and thus will result in new findings. This review emphasizes the state-of-the-art research on O2(•-) so as to enable researchers to venture into future research. It comprises the main characteristics of O2(•-) followed by generation methods. The reaction types of O2(•-) are reviewed, and its potential applications including the destruction of hazardous chemicals, synthesis of organic compounds, and many other applications are highlighted. The O2(•-) environmental chemistry is also discussed. The detection methods of O2(•-) are categorized and elaborated. Special attention is given to the feasibility of using ionic liquids as media for O2(•-), addressing the latest progress of generation and applications. The effect of electrodes on the O2(•-) electrochemical generation is reviewed. Finally, some remarks and future perspectives are concluded.

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Section: Generation Of the Superoxide Ionmentioning

confidence: 99%

Superoxide Ion: Generation and Chemical Implications

Hayyan¹,

Hashim²,

AlNashef³

2016

Chem. Rev.

1,713

1,058

View full text Add to dashboard Cite

show abstract

“…In addition, the pKa value of rutin is about 5.4. 39 That is, rutin is present in a formation of molecule in pH 4.0 solution so that electron and proton can diffuse easily to the GC electrode surface. When in pH 9.0 solution, rutin exited as ionic formation leading to the hinder of electron and proton-transfer to the electrode surface.…”

Section: Resultsmentioning

confidence: 99%

The Fabrication of Multiple Stimuli-Responsive Film Electrode and Logic Gates of Rutin

Hou

Xue

et al. 2020

J. Electrochem. Soc.

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The glassy carbon (GC) electrode surface modified with carboxylic multi-walled carbon nanotubes (c-MWCNTs) and poly(N-isopropylacrylamide) (PNIPAM) films were used to investigate multiple switching electrochemical behaviors of rutin, and a 4-input/3-output logic-gate system was constructed. The drug molecule rutin acted as electroactive probe, and displayed triple stimuli-responsive switchable cyclic voltammetry (CV) properties on c-MWCNTs/PNIPAM film electrodes. From pH 4.0 to pH 9.0 at 25 °C, the peak currents of rutin were decreasing with the pH value increasing due to the property of rutin itself and the electrostatic interaction between polyacrylamide (PAA) in the film and rutin molecule. When external temperature and Na2SO4 concentration increased, the CV response signals of rutin decreased because the hydrogen bonds between amide group of PNIPAM hydrogel polymer and water molecules were broken gradually, and a collapsed globule structure was formed. According to above results, multiple stimulus-responsive hydrogel thin film sensor was constructed. Then a 4-input/3-output logic-gate system including AND, NAND and INHIBIT gates was fabricated successfully. The construction of logic-gate system based on drug molecule rutin may provide a novel approach and model leading to design the new-style drug sensor, which might be applied to the intelligent medical diagnostics and drug release.

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“…For example, hyperoside (CID5281643), a quercetin3-O-D-galactoside (i.e., quercetin with a beta-D-galactosyl residue attached at position 3), is a flavonol glycoside present in a variety of vegetables and fruits [26]. It is predominant in Hypericum mysorense [27]. Hyperoside has been reported to have neuroprotective effects [28], cardioprotective activity [29] and antioxidant activity [30,31].…”

Section: Discussionmentioning

confidence: 99%

Molecular docking, simulation and binding free energy analysis of small molecules as PfHT1 inhibitors

Owoloye

Ligali

Enejoh

et al. 2022

Preprint

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Malaria chemotherapy has been plagued by parasite resistance. Novel drugs must be continually explored for malaria treatment. Plasmodium falciparum requires host glucose for survival and proliferation. Protein involved in hexose permeation, P. falciparum hexose transporter 1 (PfHT1) is a potential drug target. We performed high throughput virtual screening of 21,352 small-molecule compounds against PfHT1. The stability of the lead compound complexes was evaluated via molecular dynamics (MD) simulation for 100 nanoseconds. We also investigated the pharmacodynamic, pharmacokinetic and physiological characteristics of the compounds in accordance with Lipinksi rules for drug-likeness to bind and inhibit PfHT1. Molecular docking and free binding energy analyses were carried out using Molecular Mechanics with Generalised Born and Surface Area (MMGBSA) solvation to determine the selectivity of the hit compounds for PfHT1 over the human glucose transporter (hGLUT1) orthologue. Five important compounds were identified: Hyperoside (CID5281643); avicularin (CID5490064); sylibin (CID5213); harpagoside (CID5481542) and quercetagetin (CID5281680). The compounds formed intermolecular interaction with the binding pocket of the target via conserved amino acid residues (Val314, Gly183, Thr49, Asn52, Gly183, Ser315, Ser317, and Asn48). The MMGBSA analysis of the complexes yielded high free binding energies. Four (CID5281643, CID5490064, CID5213, and CID5481542) of the identified compounds were found to be stable within the PfHT1 binding pocket throughout the 100 nanoseconds simulation run time. The four compounds demonstrated higher affinity for PfHT1 than the human major glucose transporter (hGLUT1). This investigation demonstrates the inhibition potential of sylibin, hyperoside, harpagoside, and avicularin against PfHT1 receptor. Robust preclinical investigations are required to validate the chemotherapeutic properties of the identified compounds.

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A pulse radiolysis study of hyperoside isolated from Hypericum mysorense

Cited by 7 publications

References 54 publications

Superoxide Ion: Generation and Chemical Implications

Superoxide Ion: Generation and Chemical Implications

The Fabrication of Multiple Stimuli-Responsive Film Electrode and Logic Gates of Rutin

Molecular docking, simulation and binding free energy analysis of small molecules as PfHT1 inhibitors

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