A pulsed time‐of‐flight mass spectrometer for liquid secondary ion mass spectrometry

Olthoff, James K.; Lys, Ihor; Cotter, Robert J.

doi:10.1002/rcm.1290020902

Cited by 30 publications

(11 citation statements)

References 9 publications

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“…(A recent article by Fenselau on MALDI MS and strategies for protein analysis is recommended for interested readers [4].. The growth of this technique has been further accelerated by innovative MS methods for polymer analysis, including new matrices for analyzing high-mass compounds (5-7); reproducible sample preparation procedures (8); improved instrumentation, including postsource decay (9); delayed extraction (10)(11)(12)(13); and enhanced ion optics and improved data-processing software…”

Section: Overview Of Maldimentioning

confidence: 99%

Peer Reviewed: Characterizing Synthetic Polymers by MALDI MS

Odom²

1998

Anal. Chem.

105

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Section: Overview Of Maldimentioning

confidence: 99%

Peer Reviewed: Characterizing Synthetic Polymers by MALDI MS

Odom²

1998

Anal. Chem.

105

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“…At the same time, the inability to provide efficient differential pumping on TOF instruments may exclude the use of the high flow rate (1 mL/min) thermospray techniques, and therefore makes the continuous-flow probe (1)(2)(3)(4)(5), combined with ion or atom bombardment, a more attractive approach.…”

Section: Resultsmentioning

confidence: 99%

A continuous‐flow probe high performance liquid chromatography interface to a liquid secondary‐ion time‐of‐flight mass spectrometer

Chen

Cotter

Caprioli

1988

Rapid Comm Mass Spectrometry

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NEOPENTANE IN CI MASS SPECTROMETRYthese aged filaments would have burned out soon after switching to even higher emission current settings. The total "on" times for the filaments were 34 h 55 min in the presence of isobutane and 65 h 40 min when neopentane was used, indicating a doubling of lifetime.Sustained operation of coiled tungsten filaments in the presence of either gas resulted in increased brittleness, requiring careful handling during source cleaning. There was usually less observable carbon deposition on the ceramics and block adjacent to the filament with neopentane than with isobutane.In summary, replacing isobutane with neopentane as a chemical ionization reagent gas increases the lifetime of tungsten filaments significantly without compromising the quality of mass spectra and without significant additional cost. The possibilities for using the time-of-flight analyzer as a liquid chromatography detector are evaluated using a continuous flow probe and keV ion bombardment on a specially designed time-of-flight instrument.We recently the design and performance of a liquid secondary-ion time-of-flight mass spectrometer (liquid-SIMS TQF) for the analysis of large and/or thermally labile samples. The instrument incorporated the two-stage ion extraction and "time-lag focusing" design of Wiley and McLaren3 for simultaneous time, spatial and energy focusing. In this case, however, low voltage pulsed-ion extraction from a grounded ion source was employed, to be compatible with the introduction of a liquid sample matrix, to provide maximum spatial focusing for secondary ions desorbed from an irregular surface, and to permit the use of broad (1-10 ps), high flux (1-15 pA/cm2) primary ion pulses. Additionally, this configuration permitted the recording of analog signals during each time-of-flight cycle, so that complete mass spectra are obtained in several seconds by averaging the signal from several cycles at high repetition rate. Thus, this configuration was developed as a ~iiore appropriate analyzer for liquid SIMS than the constant field, high voltage extraction configurations employed in plasma desorption mass spectrometry (PDMS)4 and static SIMS' TQF instruments, where samples must be deposited as thin layers on an ' Author to whom correspondence should be addressed. equipotential surface and mass spectra are obtained through the accumulation of many time-interval measurements.6Holland et aL7 have noted that TQF mass spectrometry combined with gas chromatography may ultimately provide a method for GUMS analysis with very high sensitivity and low chromatographic distortion. Their approach, known as "time array" detection, relies upon the recording of analog data at very high repetition rate. In addition to high speed and high ion transmission, TOF mass analyzers are capable of recording ions over a wide mass range. Thus, it would appear that such analyzers would also be ideal for use as detectors for high performance liquid chromatography, employing soft ionization interfaces to permit the recording of mole...

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“…The time needed until they reach the detector depends on their mass-to-charge ratio. Ions with a small weight travel faster and hit the detector earlier than heavier ions (Olthoff et al, 1988). TOF methodology is used in a linear fashion or, aided by electrostatic grids and lenses, as a reflectron.…”

Section: Time Of Flight (Tof) Mass Analysermentioning

confidence: 99%

Mass spectrometry-based proteomics and its potential use in haematological research

Fröbel¹,

Lehr

Haas

et al. 2009

Archives of Physiology and Biochemistry

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In the last decade proteomics has made great progress reaching throughput and comprehensiveness comparable to genomics technologies. Mass spectrometry plays a key role in proteomics and has become an indispensable method for molecular and cellular biology because many cellular changes in response to internal or external stimuli can only be detected at the proteome level. Furthermore, different from genomics which depends on the availability of DNA or RNA, proteomics is not restricted to cellular samples, but also allows the analysis of biological fluids like serum, plasma or urine. This article provides an overview of the recent developments in proteomics techniques useful for haematological research.

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A pulsed time‐of‐flight mass spectrometer for liquid secondary ion mass spectrometry

Cited by 30 publications

References 9 publications

Peer Reviewed: Characterizing Synthetic Polymers by MALDI MS

Peer Reviewed: Characterizing Synthetic Polymers by MALDI MS

A continuous‐flow probe high performance liquid chromatography interface to a liquid secondary‐ion time‐of‐flight mass spectrometer

Mass spectrometry-based proteomics and its potential use in haematological research

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