A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature

Rao, Kvl Narasinga; Konar, Subhas; Gangadharan, Jagathlal; Vazhayil, Vikas; Somanna, Sampath

doi:10.4103/0976-3147.169869

Cited by 29 publications

(29 citation statements)

References 7 publications

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“…Several previous studies have reported metastases of ovarian choriocarcinoma to distant sites (11). For instance, Rao et al reported a solitary brain metastasis in a patient with non-gestational ovarian choriocarcinoma after two years of treatment (2). In addition, bilateral pulmonary metastases in a patient after the completion of chemotherapy was reported (6,12).…”

Section: Discussionmentioning

confidence: 99%

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Primary Pure Non-Gestational Ovarian Choriocarcinoma: A Case Report

et al. 2017

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Introduction: Pure non-gestational ovarian choriocarcinoma is a rare malignant condition with aggressive behavior. The tumor arises from germ cells of ovarian. Few cases have been reported in the literature. We present a case of pure ovarian choriocarcinoma with disseminated tumor in pelvic. Case Presentation: A 16-year-old girl was referred to Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran in April 2016 with acute abdominal pain, abdomino pelvic mass and vaginal bleeding. In addition, an extremely high level of sub unit of human chorionic gonadotropin β-hCG was detected. Based on the emergency condition, she underwent laparotomy and left salpingo-oophorectomy with suboptimal resection of the tumor. Histopathology revealed a tumor compatible with pure nongestational ovarian choriocarcinoma. Adjuvant chemotherapy was performed based on 4 courses of bleomycin-etoposide-cisplatin (BEP) regimen. She is now under chemotherapy. Conclusions:We recommend the use of minimally invasive, fertility-preserving surgeries in patients with non-gestational ovarian choriocarcinomas.

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Section: Discussionmentioning

confidence: 99%

“…In a detailed summary and analysis, about 30 cases of pure non-gestational choriocarcinoma were reported (2). Nongestational ovarian choriocarcinoma usually occurs along with other germ cell tumors.…”

Section: Introductionmentioning

confidence: 99%

Primary Pure Non-Gestational Ovarian Choriocarcinoma: A Case Report

et al. 2017

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“…9 Non gestational choriocarcinomas are resistant to single-agent chemotherapy and have a worse prognosis as compared to gestational choriocarcinomas. 10 Morphologically, the presence of a well developed corpus luteum of pregnancy adjacent to the tumour may be indicative of a gestational origin. 7 This was not seen in our case.…”

Section: Discussionmentioning

confidence: 99%

Primary pure non-gestational choriocarcinoma of ovary: a rare case report

Rawal

Ahluwalia

Yadav

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Germ cell malignancies represent 15% of ovarian cancers. Choriocarcinoma is a malignant tumour with trophoblastic differentiation. It may be gestational or non-gestational and may be a primary tumour or metastatic from other organs. Pure non-gestational choriocarcinoma is an extremely rare neoplasm, with reports of only a few cases. This study reports a rare case of non-gestational pure choriocarcinoma in a postmenarcheal young female and describes details of the tumour, including the clinicopathological findings. A young female presented with sudden onset anxiety, abdominal distention, severe abdominal pain, and severe pallor. Clinically, she was diagnosed as a case of ruptured ectopic pregnancy, and was taken up for emergency laparotomy. A right ovarian mass of 5X7 cm was seen, which was ruptured and was bleeding profusely. Right salpingo-oophorectomy was done, and it was diagnosed histopathologically as primary pure non-gestational choriocarcinoma of ovary. This case report describes the histopathological and immunohistochemical findings of this rare entity, as well as the various methods to differentiate between cases of non-gestational and gestational choriocarcinoma of the ovary. This is important as non-gestational choriocarcinoma has a poorer prognosis in comparison with gestational. Also, the treatment regimen for the two differs.

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“…The majority of NGCO cases have been confirmed by post-surgical pathological diagnoses (4). The major treatment for NGOC is surgery combined with chemotherapy, but patients often have a poor prognosis (3,4).…”

Section: Introductionmentioning

confidence: 98%

“…The rate of occurrence in pure primary NGOC is <1% (3). The clinical manifestations of NGCO include vaginal bleeding, abdominal pain and pelvic masses, so the majority of cases are misdiagnosed and are initially treated for ovarian tumor torsion or ovarian cancer (3,4).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological analysis of non-gestational ovarian choriocarcinoma: Report of two cases and review of the literature

et al. 2016

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Abstract. The aim of the present study was to analyze the clinicopathological features of two cases of non-gestational ovarian choriocarcinoma (NGCO). The histopathological, immunohistochemical and clinical features of two cases of NGCO in the left ovaries of two 13 year-old female patients were investigated and the relevant literature was reviewed. In both cases, the tumor masses exhibited cribriform, papillary and nested cellular growth patterns, and hemorrhage and necrosis were evident. In case one, the patient also exhibited a sex cord tumor with annular tubules (SCTAT) in the right ovary. To the best of our knowledge, the synchronous occurrence of these two tumor types has not been reported previously. Immunohistochemically, the tumor cells of choriocarcinoma in both cases were positive for human chorionic gonadotropin and cytokeratin, while those of SCTAT were positive for CD56 and CD99. NGCO is an extremely rare germ cell tumor of high-grade malignancy, and STCAT is even rarer. Early metastasis of NGCO is common and the disease has a poor prognosis. In the present study, one patient succumbed within 4 months of diagnosis with NGCO and the other patient was lost to follow-up after 12 months.

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A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature

Cited by 29 publications

References 7 publications

Primary Pure Non-Gestational Ovarian Choriocarcinoma: A Case Report

Primary Pure Non-Gestational Ovarian Choriocarcinoma: A Case Report

Primary pure non-gestational choriocarcinoma of ovary: a rare case report

Clinicopathological analysis of non-gestational ovarian choriocarcinoma: Report of two cases and review of the literature

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