A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): Relationship to juvenile hormone biosynthesis?

Burtenshaw, Sally M.; Su, Peipei; Zhang, J.R.; Tobe, Stephen S.; Dayton, Louisa; Bendena, William G.

doi:10.1016/j.peptides.2007.10.030

Cited by 39 publications

(32 citation statements)

References 27 publications

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“…The data indicate that FAMeT does not have an FA methyltransferase function in S. gregaria. Moreover, together with the previous studies on FAMeT in D. melanogaster (Burtenshaw et al, 2008;Zhang et al, 2010), there is reasonable evidence from different insect species showing that FAMeT is not what its name indicates.…”

Section: Discussionsupporting

confidence: 54%

“…However, subsequent studies in other Crustacea (Litopenaeus vannamei, Homarus americanus, Cancer pagurus) and insect species (Ceratitis capitata, Nilaparvata lugens and Melipona scutellaris) did not verify this activity (Holford et al, 2004;Hui et al, 2008;Liu et al, 2010;Ruddell et al, 2003;Vannini et al, 2010;Vieira et al, 2008). Moreover, two recent studies in D. melanogaster have shown that DmFAMeT is not involved in JH biosynthesis (Burtenshaw et al, 2008;Zhang et al, 2010).…”

Section: Introductionmentioning

confidence: 96%

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Final steps in juvenile hormone biosynthesis in the desert locust, Schistocerca gregaria

Marchal

Zhang

Badisco

et al. 2011

Insect Biochemistry and Molecular Biology

111

105

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 96%

Final steps in juvenile hormone biosynthesis in the desert locust, Schistocerca gregaria

Marchal

Zhang

Badisco

et al. 2011

Insect Biochemistry and Molecular Biology

111

105

View full text Add to dashboard Cite

“…In the fruit fly, D. melanogaster , a recombinant FAMeT (rFAMeT) was cloned, expressed, and a specific antiserum was generated. Immunohistochemical analysis confirmed the presence of FAMeT in the CA portion of the ring gland, but rFAMeT presented no enzymatic activity in a radiochemical assay, inferring that D. melanogaster FAMeT has little, if any role in sesquiterpenoid biosynthesis [31]. Notwithstanding, the Dm JHAMT gene is predominantly expressed in the fly CA.…”

Section: Discussionmentioning

confidence: 86%

Juvenile Hormone Biosynthesis Gene Expression in the corpora allata of Honey Bee (Apis mellifera L.) Female Castes

et al. 2014

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Juvenile hormone (JH) controls key events in the honey bee life cycle, viz. caste development and age polyethism. We quantified transcript abundance of 24 genes involved in the JH biosynthetic pathway in the corpora allata-corpora cardiaca (CA-CC) complex. The expression of six of these genes showing relatively high transcript abundance was contrasted with CA size, hemolymph JH titer, as well as JH degradation rates and JH esterase (jhe) transcript levels. Gene expression did not match the contrasting JH titers in queen and worker fourth instar larvae, but jhe transcript abundance and JH degradation rates were significantly lower in queen larvae. Consequently, transcriptional control of JHE is of importance in regulating larval JH titers and caste development. In contrast, the same analyses applied to adult worker bees allowed us inferring that the high JH levels in foragers are due to increased JH synthesis. Upon RNAi-mediated silencing of the methyl farnesoate epoxidase gene (mfe) encoding the enzyme that catalyzes methyl farnesoate-to-JH conversion, the JH titer was decreased, thus corroborating that JH titer regulation in adult honey bees depends on this final JH biosynthesis step. The molecular pathway differences underlying JH titer regulation in larval caste development versus adult age polyethism lead us to propose that mfe and jhe genes be assayed when addressing questions on the role(s) of JH in social evolution.

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“…FAMeT has been found to exist in insects and crustaceans (Hui et al , 2010), and evidence from D. melanogaster has suggested that FAMeT has a minor role in JH biosynthesis, but it may play a major role in JH signaling (Burtenshaw et al , 2008; Zhang et al , 2010). Our data revealed that in the B. mori genome, there are seven FAMeT- like genes, each of which contains two typical Methyltransf_FA and DM9 domains.…”

Section: Resultsmentioning

confidence: 99%

“…However, JHAMT and FAMeT, two enzymes involved in the methyl esterification of FA, were predicted in B. mori and other insects (Table 2 and Table S2). Previous studies in D. melanogaster have reported that FAMeT was likely not involved in JH biosynthesis (Burtenshaw et al , 2008; Zhang et al , 2010). However, another analysis speculated that FAMeT-mediated methyl esterification should exist in insects and crustaceans (Hui et al , 2010).…”

Section: Discussionmentioning

confidence: 96%

Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects

et al. 2014

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Juvenile hormone (JH) contributes to the regulation of larval molting and metamorphosis in insects. Herein, we comprehensively identified 55 genes involved in JH biosynthesis, metabolism and signaling in the silkworm (Bombyx mori) as well as 35 in Drosophila melanogaster, 35 in Anopheles gambiae, 36 in Apis mellifera, 47 in Tribolium castaneum, and 44 in Danaus plexippus. Comparative analysis showed that each gene involved in the early steps of the mevalonate (MVA) pathway, in the neuropeptide regulation of JH biosynthesis, or in JH signaling is a single copy in B. mori and other surveyed insects, indicating that these JH-related pathways or steps are likely conserved in all surveyed insects. However, each gene participating in the isoprenoid branch of JH biosynthesis and JH metabolism, together with the FPPS genes for catalyzing the final step of the MVA pathway of JH biosynthesis, exhibited an obvious duplication in Lepidoptera, including B. mori and D. plexippus. Microarray and real-time RT-PCR analysis revealed that different copies of several JH-related genes presented expression changes that correlated with the dynamics of JH titer during larval growth and metamorphosis. Taken together, the findings suggest that duplication-derived copy variation of JH-related genes might be evolutionarily associated with the variation of JH types between Lepidoptera and other insect orders. In conclusion, our results provide useful clues for further functional analysis of JH-related genes in B. mori and other insects.

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A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): Relationship to juvenile hormone biosynthesis?

Cited by 39 publications

References 27 publications

Final steps in juvenile hormone biosynthesis in the desert locust, Schistocerca gregaria

Final steps in juvenile hormone biosynthesis in the desert locust, Schistocerca gregaria

Juvenile Hormone Biosynthesis Gene Expression in the corpora allata of Honey Bee (Apis mellifera L.) Female Castes

Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects

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