A Qualitative and Quantitative Study of Renin in the Different Layers of the Rabbit Uterus

Bing, Jèns; Faarup, Poul

doi:10.1111/apm.1966.67.2.169

Cited by 29 publications

(8 citation statements)

References 6 publications

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“…In the rat uterine wall the concentrations of active renin and prorenin were low (Nielsen et al 1991a). In the rabbit uterus very high concentrations of active renin and prorenin, which increases during pregnancy, have been demonstrated in both myometrium and endometrium (Bing & Faarup 1966;Dzau et al 1987).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the increased plasma prorenin in humans during pregnancy (Skinner et al 1975) and in relation to ovulation (Sealey et al 1985) is probably due to an increased secretion from the uteroplacental unit (Brar et al 1986) and the ovaries ). The renin-angiotensin system has been most extensively studied in relation to reproduction in humans, but it has also been demonstrated in different reproductive tissues and fluids from animals such as cat (Stakemann 1960;Rubattu et al 1991), rabbit (Gross et al 1964;Bing & Faarup 1966), dog (Hondari et al 1969), mouse (Rix et al 1980;Jacobsen & Poulsen 1984), rat (Gutman & Mazur-Ruder 1976;Nielsen et al 1991a), sheep (Rawashdeh et al 1991), cattle (Hagemann et al 1992) and pig (Gould et al 1964;Hagemann et at. 1992).…”

Section: Introductionmentioning

confidence: 99%

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Renin and Prorenin in Reproductive Tissues During Gestation in Pigs and Cattle

Hagemann¹,

Dantzer²,

Nielsen³

et al. 1993

Clin Exp Pharma Physio

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1. High concentrations of prorenin and active renin were previously found in ovarian follicular fluid from cattle but not from pigs. In the present study female reproductive tissues and fluids from cattle and pigs during gestation were investigated to clarify a possible species difference in active renin and prorenin concentrations. 2. Very high concentrations of active renin but no prorenin were found in corpus luteum from both species. 3. Relatively low concentrations of active renin, in the same order as in maternal blood plasma, were found in myometrium, endometrium, placenta and fetal membranes from both species. Prorenin was undetectable in these tissues except for bovine myometrium and porcine endometrium in some animals. 4. The concentrations of active renin and prorenin in amnionic fluid from both species were below the maternal plasma values. In allantoic fluid the concentrations were higher than in amnionic fluid. 5. The plasma concentrations of active renin and prorenin did not change during gestation in pigs. This finding is in contrast to the observations in humans and does not support a systemic effect of prorenin during gestation. 6. The presence of renin in the reproductive tissues, especially the very high concentrations in the corpus luteum, indicates a local function of the renin-angiotensin system during gestation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renin and Prorenin in Reproductive Tissues During Gestation in Pigs and Cattle

Hagemann¹,

Dantzer²,

Nielsen³

et al. 1993

Clin Exp Pharma Physio

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“…During pregnancy, the concentration of renin in the uterus increases, especially at the end of pregnancy [Bing and Faarup, 1966],…”

Section: Discussionmentioning

confidence: 99%

Morphological aspect of the juxtaglomerular apparatus and adrenal zona glomerulosa during pregnancy in rabbits

Mrsevic¹,

Lačković²,

Mujović³

et al. 1980

Cells Tissues Organs

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The juxtaglomerular apparatus and zona glomerulosa were studied histologically in rabbits during the whole pregnancy period. The granularity of the kidney juxtaglomerular cells diminishes up to 25 days at which time it reaches control values. After delivery, the juxtaglomerular index increases significantly and rises above control values. The width of the adrenal zona glomerulosa is smaller in the first half of pregnancy in comparison with controls. In the second half it rises significantly. After delivery it greatly surpasses control values.

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“…41,42 Renin is now recognised as being widely distributed, and is detectable in, for example, also heart, 43 blood vessels, 43 adrenal cortex, 44 ovary, 45 amniotic fluid, 46 testis, 47 epididymis, 47 eye, 48 and brain.…”

Section: Renin In Extrarenal Tissuesmentioning

confidence: 99%