Introduction: Amputation is a trauma that involves important functional, psychological and social sequelae. The International Classification of Functioning, Disability and Health (ICF) is based on the biopsychosocial model and enables understanding functioning and disability through the interaction of its components. Objective: This study’s aim was to depict functioning and disability using the ICF conceptual interaction model from the perspective of individuals who suffered a lower limb amputation. Methods: The qualitative approach was used and included a semi-structured interview held with six participants. Results: All the participants used assistive devices such as crutches, wheelchairs or walkers: three used prostheses and the other three emphasized their difficulty in acquiring prostheses from the Social Security Service or Public Health System. Social support, especially that provided by family and friends, is a major facilitator. The importance of acquiring and adapting prostheses to enable the rehabilitation of amputees became clear; however, rehabilitation is not restricted to the acquisition of prostheses. A rehabilitation program directed to restoring functionality is needed. Conclusion: The multidirectional approach using the ICF’s conceptual interaction model enabled important insights concerning public health issues, such as obstacles related to the access to rehabilitation services and a lack of preparedness on the part of health professionals in relation to care provided to amputees.