A qualitative study of soluble fibrin monomer complexes in normal labour and abruptio placentae

Estellés, Amparo; Aznar, José A.; Gilabert, J.

doi:10.1016/0049-3848(80)90347-3

Cited by 9 publications

(5 citation statements)

References 9 publications

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“…Fletcher & Alkjaersig (17), using the same techniques, found plasma fibrinogen complexes in the first trimester, similar to that seen in control nonpregnant women, increasing throughout pregnancy up to the eighth month, dropping at term, then rising again over the first two post-partum months. Estelles et al (16) found qualitative differences in the soluble fibrin monomer complexes (SFMC) of abruptio placenta when compared with normal labor.…”

Section: Discussionmentioning

confidence: 99%

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Caires

Arocha-Piñango

Rodríguez

et al. 1984

Acta Obstet Gynecol Scand

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Factor VIIIR:Ag and Factor VIII:C levels were found to be significantly increased during pregnancy, labor and puerperium, but not to the extent observed by European and American authors. The ratio Factor VIIIR:Ag/Factor VIII:C was elevated only between the third and sixth hour of labor with respect to early labor, and during parturition and early puerperium with respect to late labor. However, this ratio was in the same range as the normal non-pregnant controls, but in the cases of complicated pregnancy, the ratio reached values much higher than the normal. It was concluded that determination of the ratio appears to be of little value in normal cases but may be of use when there are obstetrical complications. Studies are being performed to try to explain the limited rise in Factor VIII:Ag and Factor VIII:C levels observed in our cases.

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Section: Discussionmentioning

confidence: 99%

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Caires

Arocha-Piñango

Rodríguez

et al. 1984

Acta Obstet Gynecol Scand

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“…The presence of SFMC and fibrinoligomers in patients with 'dead fetus syndrome' has already been described [17], and it has been reported that these SFMC may precede other alterations in hemostasis [6,17], When these complexes are studied in obstetric pa tients by polyacrylamide gel electrophoresis, it has been observed that three electropho retic bands with molecular weights greater than that of fibrinogen may appear [14]. The second of these bands is composed of crosslinked fibrin material [18].…”

Section: Discussionmentioning

confidence: 99%

“…SFMC were evaluated by 3.5% SDS-polyacrylamide gel electrophoresis, as previously described [ 13,14], The SFMC were quantified as percentages, taking the fibrinogen band as 100%. Fibrinogen-related anti gen was identified by intragel immunoprécipitation [14].…”

Section: Methodsmentioning

confidence: 99%

Soluble Fibrin Monomer Complexes and Other Hemostatic Parameters in Patients with Intrauterine Fetal Death

Gilabert¹,

Estellés²,

Aznar³

et al. 1985

Gynecol Obstet Invest

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Hemostatic parameters, especially soluble fibrin monomer complexes, have been studied in 114 patients with intrauterine fetal death. The patients were classified into three groups according to the duration of fetal retention. A correlation was observed between a longer duration of fetal retention and the hemostatic alteration. Moreover, in the groups of patients in which this hemostatic disorder was more evident, an improvement in these alterations was detected after fetal evacuation. A hemorrhagic picture with consumption of coagulation factors and cross-linked fibrin oligomers was detected after uterine evacuation in only 1 case and required an emergency hysterectomy and the administration of blood and plasma. In the rest of the patients, fetal evacuation was sufficient to normalize the parameters and no hemorrhagic complications were observed. The favorable evolution and minimal hemostatic alterations in the majority of the patients with intrauterine fetal death, when early obstetric management was established, are discussed.

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“…The major role for plasminogen is clearing the circulatory system of blood clots [3]–[5]. Plasminogen is thought to play a key role in the tissue remodeling that occurs during pregnancy [6], [7] and that which occurs during the metastasis of tumors [8], [9]. Lastly, plasminogen is thought to help in the propagation of bacterial infections [10]–[12] as well as diseases associated with prions [13]–[15].…”

Section: Introductionmentioning

confidence: 99%

Reduction of Canine Plasminogen Leads to an Expanded Molecule which Precipitates

Kornblatt

2009

PLoS ONE

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Canine plasminogen is made up of seven domains. In each domain there are several cysteines that are linked by disulfide bonds. Reduction of a limited number of the cystines destabilizes the protein such that it precipitates. The bond or bonds that are broken provide about 14 kcal of stabilization energy. Circular dichroism and dynamic light scattering indicate that there is probably an intermediate that is formed prior to precipitation and that the intermediate is somewhat larger than the compact form of plasminogen.

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A qualitative study of soluble fibrin monomer complexes in normal labour and abruptio placentae

Cited by 9 publications

References 9 publications

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Factor VIIIR: Ag/Factor VIII:C and their Ratio in Obstetrical Cases

Soluble Fibrin Monomer Complexes and Other Hemostatic Parameters in Patients with Intrauterine Fetal Death

Reduction of Canine Plasminogen Leads to an Expanded Molecule which Precipitates

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