A Qualitative Systematic Review of the Role of N-Methyl-d-Aspartate Receptor Antagonists in Preventive Analgesia

McCartney, Colin J. L.; Sinha, A.K.; Katz, Joel

doi:10.1213/01.ane.0000108501.57073.38

Cited by 292 publications

(195 citation statements)

References 145 publications

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“…[9][10][11][12][13][14] These discrepancies may be due to the large interstudy variability in surgical procedures, patient population, dose of ketamine administered, timing of administration, and study design. 15,16 In studies that fail to demonstrate a preventive effect of a low-dose ketamine on postoperative pain, the question of whether a lack of efficacy on central sensitization is linked to insufficient pre-or postoperative blockade remains unresolved. Pre-emptive analgesia requires that a preoperative analgesic intervention reduce pain or analgesic consumption to a greater extent than the identical intervention administered after surgery.…”

Section: Methodsmentioning

confidence: 99%

Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery

Lebrun¹,

Elstraete²,

Sandefo³

et al. 2006

Can J Anesth/J Can Anesth

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Purpose: The aim of this study was to assess the effect of pre-vs postincisional low-dose iv ketamine on postoperative pain in outpatients scheduled for oral surgery under general anesthesia. Methods:Eighty-four patients were randomly assigned to receive intravenously saline before and after surgery in Group 1, ketamine 300 µg·kg -1 iv before and saline after surgery in Group 2, saline before and ketamine 300 µg·kg -1 iv after surgery in Group 3. Postoperative analgesia consisted of iv proparacetamol and ketoprofen. Rescue analgesia consisted of nalbuphine 200 µg·kg -1 iv. Analgesia at home consisted of oral ketoprofen, and acetaminophen with codeine as rescue analgesia. A telephone interview was conducted on the first and second postoperative days.Results: There were no significant differences between groups with respect to pain scores, the number of patients requiring nalbuphine in the postanesthesia care unit (PACU), (36.7%, 38.7%, and 39.5% for Groups 1, 2, and 3 respectively), or nalbuphine consumption in the PACU (66.5 µg·kg -1 ± 16.8, 75.9 µg·kg -1 ± 17.5, 66.7 µg·kg -1 ± 21.6 for Groups 1, 2, and 3 respectively). The number of rescue analgesic tablets taken at home, and time to first request for rescue analgesia, sedation scores, or side-effects were similar amongst groups. No patient required nalbuphine in the ambulatory care unit. Conclusions: There was no benefit to pre-emptive administration of ketamine 300 µg·kg -1 iv whether administered pre-or postoperatively. (36,7 %, 38,7 %, et 39,5 % respectivement pour les Groupes 1, 2 et 3), la consommation de nalbuphine (66,5 µg·kg -1 ± 16,8, 75,9 µg·kg -1 ± 17,5, 66,7 µg·kg -1 ± 21,6 respectivement pour les Groupes 1, 2 et 3), le nombre de comprimés de secours à domicile : 6 (2,13), 7 (2,20), et 7 (1,12) Objectif

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Section: Methodsmentioning

confidence: 99%

Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery

Lebrun¹,

Elstraete²,

Sandefo³

et al. 2006

Can J Anesth/J Can Anesth

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“…Двадцать че-тыре исследования соответствовали критериям включения, из них в 14 (58 %) показан положитель-ный эффект кетамина на снижение послеопераци-онной боли и/или снижение потребления анальгети-ков. Дозы кетамина, используемые в анализируемых исследованиях, колебались от 0,15 до 1 мг/кг [46]. В Кокрейновском обзоре Bell и соавт.…”

Section: применение кетамина в периоперационном периодеunclassified

Роль Кетаміну У Періопераційному Знеболюванні (Огляд)

Klygunenko¹,

Khalimonchyk²

2022

ЕМ

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“…[44] In a qualitative systematic review the effect of N-methyl-D-aspartate (NMDA) receptor antagonists on reducing postoperative pain, the evidence in favor of preventive analgesic action was strongest in the case of dextromethorphan and ketamine, with 67% and 58%, respectively, of studies suggesting a reduction in pain beyond the clinical duration of action of the given drug. [45] NMDA receptor antagonists seem to be a promising therapy for NP but additional studies are required to explore the therapeutic potential of NMDA receptor antagonists in neuropathic pain and till now they have shown mixed results, although ketamine seems to be the most promising.…”

Section: Nmda Receptor Antagonistsmentioning

confidence: 99%