Pan-sharpening is the process of fusing higher spatial resolution panchromatic (PAN) with lower spatial resolution multispectral (MS) imagery to create higher spatial resolution MS images. Here, our overall objective was to pan-sharpen Landsat-8 images and calculate vegetation greenness (i.e., normalized difference vegetation index (NDVI)), canopy structure (i.e., enhanced vegetation index (EVI)), and canopy water content (i.e., normalized difference water index (NDWI))-related variables. Our proposed methods consisted of: (i)