A quantitative analysis of growth control in the<i>Drosophila</i>eye disc

Vollmer, Jannik; Fried, Patrick; Sánchez-Aragón, Máximo; Lopes, Carla S.; Casares, Fernando; Iber, Dagmar

doi:10.1242/dev.129775

Cited by 32 publications

(66 citation statements)

References 40 publications

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“…According to an alternative model, uniformly declining growth results from a combination of Dpp signaling and mechanical feedbacks12153233. Finally, we have recently shown that the growth rate of the apical area in the Drosophila eye imaginal disc declines inversely proportional to the total apical area, which is consistent with a dilution-based mechanism for growth control34.…”

supporting

confidence: 69%

“…We have previously shown that the declining area growth rate in the eye disc can be described by an area-dependent decline34 of the form…”

Section: Resultsmentioning

confidence: 99%

“…To this end, we simulated the growth model in Eq. (1) with the growth laws that we had previously considered as candidates for growth control in the Drosophila eye disc34. In addition, we considered biphasic growth, which had previously been shown to describe wing disc growth2, and logistic growth, which had previously been shown to describe the regeneration kinetics of newt limbs14.…”

Section: Resultsmentioning

confidence: 99%

“…At the same time, there could be other growth laws that also reproduce the data and that we have not yet identified. It will be interesting whether the same mechanism limits growth in all organs and species or whether distinct mechanisms have evolved1728343940.…”

Section: Resultsmentioning

confidence: 99%

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An Unbiased Analysis of Candidate Mechanisms for the Regulation of Drosophila Wing Disc Growth

Vollmer

Iber

2016

Sci Rep

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The control of organ size presents a fundamental open problem in biology. A declining growth rate is observed in all studied higher animals, and the growth limiting mechanism may therefore be evolutionary conserved. Most studies of organ growth control have been carried out in Drosophila imaginal discs. We have previously shown that the area growth rate in the Drosophila eye primordium declines inversely proportional to the increase in its area, which is consistent with a dilution mechanism for growth control. Here, we show that a dilution mechanism cannot explain growth control in the Drosophila wing disc. We computationally evaluate a range of alternative candidate mechanisms and show that the experimental data can be best explained by a biphasic growth law. However, also logistic growth and an exponentially declining growth rate fit the data very well. The three growth laws correspond to fundamentally different growth mechanisms that we discuss. Since, as we show, a fit to the available experimental growth kinetics is insufficient to define the underlying mechanism of growth control, future experimental studies must focus on the molecular mechanisms to define the mechanism of growth control.

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supporting

confidence: 69%

“…We have previously shown that the declining area growth rate in the eye disc can be described by an area-dependent decline34 of the form…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

An Unbiased Analysis of Candidate Mechanisms for the Regulation of Drosophila Wing Disc Growth

Vollmer

Iber

2016

Sci Rep

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“…Pupal wing discs were dissected at 30 and 48 hours post puparium formation. Staining and confocal imaging was carried out as described [26].…”

Section: Imaging Of Tissue Samplesmentioning

confidence: 99%

Minimisation of surface energy drives apical epithelial organisation and gives rise to Lewis’ law

Kokic

Iannini

Villa-Fombuena

et al. 2019

Preprint

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100

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The packing of cells in epithelia exhibits striking regularities, regardless of the organism and organ. One of these regularities is expressed in Lewis' law, which states that the average apical cell area is linearly related to the number of neighbours, such that cells with larger apical area have on average more neighbours. The driving forces behind the almost 100-year old Lewis' law have remained elusive. We now provide evidence that the observed apical epithelial packing minimizes surface energy at the intercellular apical adhesion belt. Lewis' law emerges because the apical cell surfaces then assume the most regular polygonal shapes within a contiguous lattice, thus minimising the average perimeter per cell, and thereby surface energy. We predict that the linear Lewis' law generalizes to a quadratic law if the variability in apical areas is increased beyond what is normally found in epithelia. We confirm this prediction experimentally by generating heterogeneity in cell growth in Drosophila epithelia. Our discovery provides a link between epithelial organisation, cell division and growth and has implications for the general understanding of epithelial dynamics.

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The fly eye: Through the looking glass

Kumar

2017

Developmental Dynamics

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The developing eye-antennal disc of Drosophila melanogaster has been studied for more than a century, and it has been used as a model system to study diverse processes, such as tissue specification, organ growth, programmed cell death, compartment boundaries, pattern formation, cell fate specification, and planar cell polarity. The findings that have come out of these studies have informed our understanding of basic developmental processes as well as human disease. For example, the isolation of a white-eyed fly ultimately led to a greater appreciation of the role that sex chromosomes play in development, sex determination, and sex linked genetic disorders. Similarly, the discovery of the Sevenless receptor tyrosine kinase pathway not only revealed how the fate of the R7 photoreceptor is selected but it also helped our understanding of how disruptions in similar biochemical pathways result in tumorigenesis and cancer onset. In this article, I will discuss some underappreciated areas of fly eye development that are fertile for investigation and are ripe for producing exciting new breakthroughs. The topics covered here include organ shape, growth control, inductive signaling, and right-left symmetry. Developmental Dynamics 247:111-123, 2018. © 2017 Wiley Periodicals, Inc.

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A quantitative analysis of growth control in theDrosophilaeye disc

Cited by 32 publications

References 40 publications

An Unbiased Analysis of Candidate Mechanisms for the Regulation of Drosophila Wing Disc Growth

An Unbiased Analysis of Candidate Mechanisms for the Regulation of Drosophila Wing Disc Growth

Minimisation of surface energy drives apical epithelial organisation and gives rise to Lewis’ law

The fly eye: Through the looking glass

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