A quantitative near-infrared spectroscopy study: A decrease in cerebral hemoglobin oxygenation in Alzheimer’s disease and mild cognitive impairment

Arai, Heii; Takano, Maki; Miyakawa, Koichi; Ota, Tsuneyoshi; Takahashi, Tadashi; Asaka, Hirokazu; Kawaguchi, Tsuneaki

doi:10.1016/j.bandc.2005.12.012

Cited by 90 publications

(90 citation statements)

References 20 publications

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“…According to the representative hemodynamic time-course model that reported in former study [8], we considered an image pixel as activated if the [oxy-Hb] concentration change showed a steady rise after the onset of the stimuli, lasting a plateau period for a while and then dropped gradually to the initial line. We selected the channels that almost fit the above-mentioned pattern and in which the hemoglobin concentration change was most prominent to further analyze.…”

Section: E Data Analysismentioning

confidence: 99%

NIRS Measurement of Hemodynamic Evoked Responses in the Primary Sensorimotor Cortex

Xu¹,

Takata²,

et al. 2007

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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To investigate the relationship between neuronal activity and hemodynamics, we carried out a near-infrared spectroscopy (NIRS) study to measure the regional changes of hemoglobin concentration associated with cortical activation in the human sensorimotor cortex (SMI) to both voluntary and nonvoluntary tasks. We measured the hemodynamic evoked responses to voluntary finger movement and nonvoluntary electrical stimulation applied on the fingers (thumb and ring finger, respectively). Measurements were performed on 6 healthy right-handed volunteers using block paradigms and we analyzed both the spatial/temporal features and the magnitude of the optical signal induced by cerebral activation during these protocols. We constantly observed an increase in the cerebral concentration of oxygenated hemoglobin at the cortical side contralateral to the stimulated side. Our findings are in agreement with results in positron emission tomography (PET), functional magnetic resonance imaging (fMRI) and EEG (Electroencephalogram).

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Section: E Data Analysismentioning

confidence: 99%

NIRS Measurement of Hemodynamic Evoked Responses in the Primary Sensorimotor Cortex

Xu¹,

Takata²,

et al. 2007

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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“…Therefore, the significance of an effective Hb modulator is by no means less than Hb itself in transporting oxygen. For instance, a markedly reduced cerebral Hb oxygenation level was observed for patients with AD, causing improper activation of brain function in the degenerating brain area 40, 41 . Two recent studies further established the close correlations between age-related 2,3-BPG metabolism disorder and neurodegenerative diseases, including both AD and non-AD dementia 39, 42 .…”

Section: Introductionmentioning

confidence: 99%

Phthalide Derivatives from Angelica Sinensis Decrease Hemoglobin Oxygen Affinity: A New Allosteric-Modulating Mechanism and Potential Use as 2,3-BPG Functional Substitutes

Chen

Zulfajri

et al. 2017

Sci Rep

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Angelica sinensis (AS), one of the most versatile herbal medicines remains widely used due to its multi-faceted pharmacologic activities. Besides its traditional use as the blood-nourishing tonic, its anti-hypertensive, anti-cardiovascular, neuroprotective and anti-cancer effects have been reported. Albeit the significant therapeutic effects, how AS exerts such diverse efficacies from the molecular level remains elusive. Here we investigate the influences of AS and four representative phthalide derivatives from AS on the structure and function of hemoglobin (Hb). From the spectroscopy and oxygen equilibrium experiments, we show that AS and the chosen phthalides inhibited the oxygenated Hb from transforming into the high-affinity “relaxed” (R) state, decreasing Hb’s oxygen affinity. It reveals that phthalides cooperate with the endogenous Hb modulator, 2,3-bisphosphoglycerate (2,3-BPG) to synergetically regulate Hb allostery. From the docking modeling, phthalides appear to interact with Hb mainly through its α1/α2 interface, likely strengthening four (out of six) Hb “tense” (T) state stabilizing salt-bridges. A new allosteric-modulating mechanism is proposed to rationalize the capacity of phthalides to facilitate Hb oxygen transport, which may be inherently correlated with the therapeutic activities of AS. The potential of phthalides to serve as 2,3-BPG substitutes/supplements and their implications in the systemic biology and preventive medicine are discussed.

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“…AD studies have reported a reduction of prefrontal oxygenation in both the frontal and parietal lobes in AD groups during verbal fluency tasks [29,30]. In addition, another AD study found activation deficits in the parietal cortex during a visuospatial task in an AD group [31].…”

Section: Fig5mentioning

confidence: 99%

Moderate Exercise Improves Cognitive Performance and Decreases Cortical Activation in Go/No-Go Task

Murata¹

2015

BAOJMN

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Background: A lot of studies have reported that physical activity has a beneficial influence not only on physical and mental disorders but also on cognitive and brain function. Performance of a go/no-go task improves after exercise. However, few studies have compared neural activity in a go/no-go task performed before and after exercise to identify brain regions that may respond to exercise and underlie this result. Therefore, the purpose of this study was to examine the brain blood flow and compare the cortical activation pattern during a go/no-go task performed before and after exercise.

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A quantitative near-infrared spectroscopy study: A decrease in cerebral hemoglobin oxygenation in Alzheimer’s disease and mild cognitive impairment

Cited by 90 publications

References 20 publications

NIRS Measurement of Hemodynamic Evoked Responses in the Primary Sensorimotor Cortex

NIRS Measurement of Hemodynamic Evoked Responses in the Primary Sensorimotor Cortex

Phthalide Derivatives from Angelica Sinensis Decrease Hemoglobin Oxygen Affinity: A New Allosteric-Modulating Mechanism and Potential Use as 2,3-BPG Functional Substitutes

Moderate Exercise Improves Cognitive Performance and Decreases Cortical Activation in Go/No-Go Task

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