A quantum dot-based lateral flow immunoassay for the sensitive detection of human heart fatty acid binding protein (hFABP) in human serum

Savin, Mihaela; Mihailescu, Carmen-Marinela; Matei, Iulia; Stan, Dana; Moldovan, Carmen; Ion, Marian; Ion, Baciu

doi:10.1016/j.talanta.2017.10.045

Cited by 50 publications

(25 citation statements)

References 21 publications

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“…By using the lateral flow immunoassay method, the detection of human heart fatty acid‐binding protein (hFABP) was done by the Savin et al . Furthermore, the method used fluorescent labeling of water‐soluble CdTe dots linked covalently to anti‐hFABP antibodies and provide a rapid method for the quantification of hFABP in human serum [112] …”

Section: Applications Of Carbon Dotsmentioning

confidence: 99%

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi‐Sensing Platform

et al. 2021

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Carbon has always found a spotlight in human life either in the form of graphite, diamonds, activated charcoal, carbon nanotubes, or carbon dots (CDs). Carbon quantum dots (CQDs) or CDs became the centre of attraction because of their potential applications in biomedical field such as bio‐imaging, drug nanocarriers, gene therapeutics, photosensitizing agents, theranostics and provides other multifunctional diagnostic platforms. There are numerous advantages of CDs due to their biocompatibility, reduced toxicity, water‐solubility, ease of scale‐up, and, most notably their fluorescence properties contrary to other carbon nanostructures. In last few years, significant efforts have been put by various research teams to synthesize and develop nanostructured materials possessing specific functional properties and characteristics. This work focus on the recent developments in the synthetic approaches applied for CDs using environment‐friendly sources. This review also highlights the mechanistic aspects, applications of CDs in biomedicine and a multi‐sensing platform along with challenges and future perspectives of this promising field. The authors believe that this review will help audible researchers to select a suitable environment‐friendly approach for the synthesis of CDs from green sources with required functions and properties. It will also guide researchers to develop a more convenient, efficient, and environment‐friendly method for the synthesis of new tunable carbon dots.

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Section: Applications Of Carbon Dotsmentioning

confidence: 99%

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi‐Sensing Platform

et al. 2021

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“…Even being portable, such fluorescence readers are still bulky and can only operate for few hours without a power supply. Less reported but remarkable examples of handheld devices [122,123,125,129] and smartphone-based fluoresce readers [127,130] can also be found in literature. Copyright 2015 RSC); c) Schematic illustration of the ratiometric QD-FRET assay for DNA diagnostic of spinal muscular atrophy disorder and E. coli (Reprinted with permission from [129].…”

Section: Qd-based Microfluidic Paper Devicesmentioning

confidence: 99%

Quantum Dot bioconjugates for diagnostic applications

Díaz‐González

Escosura‐Muñiz

Fernández-Argüelles

et al. 2020

Topics in Current Chemistry Collections

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Quantum Dots (QDs) are a special type of engineered nanomaterials with outstanding optoelectronic properties make them as a very promising alternative to conventional luminescent dyes for biomedical applications, including biomolecule targeting, luminescence imaging as well as in drug delivery.A key parameter to ensure successful biomedical applications of QDs is that the surface of these nanomaterials should be modified with appropriate functional groups to ensure stability in aqueous solutions and conjugated with recognition elements capable to ensure an efficient tagging of the biomolecules of interest.Here, we present a review summarizing most relevant strategies for QDs surface modification and for their conjugation to biomolecules for preparation of nanoplatforms for luminescent biomolecule sensing and imaging-guided targeting. Applications of conjugations of photoluminescent QDs with different biomolecules in both in vitro and in vivo chemical sensing, immunoassays or luminescence imaging are revised. Recent progress in application of functionalized QDs in ultrasensitive detection in bioanalysis, diagnostics and imaging strategies developments are here included. Finally, some key future research goals in the progress of bioconjugation of QDs for diagnosis are identified, including novel synthetic approaches, the need of exhaustive characterization of bioconjugates or the design of signal amplification schemes.

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“…Selectivity is one of the most critical analytical parameters to assess the efficiency of a new fluorescent sensor [61,62]. In order to the capability of the method for DZN detection, the interference of some common existing substances in the environmental water samples such as metal ions and other commonly used pesticides and herbicides were investigated on the sensing system.…”

Section: Interference and Selectivity Studiesmentioning

confidence: 99%

Preparation, characterization and cell cytotoxicity of Pd-doped CdTe quantum dots and its application as a sensitive fluorescent nanoprobe

Najafi

Safari

Amani

et al. 2019

J Mater Sci: Mater Electron

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Dopants strongly affect properties and optical behaviors of quantum dots, therefore doped-QDs considered as a novel class of luminescent materials. Following development doping approach and using Pd 2+ ions as a dopant, for the first time, in this study, a facile preparation of Pd-doped CdTe QDs was reported with thioglycolic acid as a stabilizer. The essential parameters of the synthesis conditions such as dopant concentration, reaction time and optical properties of the Pd: CdTe QDs was studied. The Pd: CdTe QDs with excellent photostability and biocompatibility, exhibited a greenish emission at 529 nm. Interestingly, these nanoparticles display high fluorescence sensitivity to diazinon (DZN). Under optimal conditions, a proposed sensor was designed based on Pd: CdTe QDs which represented a wide range of linear response (2.3-100 µM), low detection limit [3.3 nM, (S/N = 3)], high stability, and selectivity. Additionally, the newly sensing nanoprobe was used for the determination of DZN in environmental water samples with satisfactory results.

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A quantum dot-based lateral flow immunoassay for the sensitive detection of human heart fatty acid binding protein (hFABP) in human serum

Cited by 50 publications

References 21 publications

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi‐Sensing Platform

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi‐Sensing Platform

Quantum Dot bioconjugates for diagnostic applications

Preparation, characterization and cell cytotoxicity of Pd-doped CdTe quantum dots and its application as a sensitive fluorescent nanoprobe

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