A quassinoid glycoside from the roots of Eurycoma longifolia

Reverse Phase High Performance Liquid Chromatography for the Quantification of Eurycomanone in <i>Eurycoma longifolia</i> Jack (Simaroubaceae) Extracts and their Commercial Products

“…E. longifolia is available commercially as capsules of raw root powder, capsules of root water extract, mixed with other aphrodisiac herbs, or as additive with tea and coffee [7]. Various bioactive compounds have been identified in E. longifolia such as 9-hydroxycanthin-6-one, 9-hydroxycanthin-6-one noxide, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one n-oxide, β-carboline-1-propionic acid, β-7-methoxycarboline-1-propionic acid, eurycomanol, eurycomanol-2-O-β-D-glucoside, 13-β-l,8dihydroeurycomanol, 14,15-dihydroxyklaineanone and eurycomanone [8][9][10][11]. Eurycomanone is the main compound in E. longifolia.…”

Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats

“…The fruit is ovoid, 1-2 cm long and 0.5-1 cm broad; its colour moves from green to blackish-red when it ripes. Phytochemical studies on this plant revealed the presence of various quassinoids, squalene derivatives, biphenylneolignans, tirucallanetype triterpenes, canthine-6-one and ␤-carboline alkaloids (Chan et al, 1989;Itokawa et al, 1992;Ang et al, 2000b). In South East Asia all the parts of Eurycoma longifolia, in particular the roots, have long been used medicinally for the treatment of different illness such as fever, intestinal worms, mouth ulcers, headache and many other general pains (Perry and Metzger, 1980).…”

Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum

“…The roots of Eurycoma longifolia Jack from the Simaroubaceae family, known locally as Tongkat Ali or Pasak Bumi in Indonesia, growing wildly in the jungle slopes of Malaysia, are popularly sought after as an essential ingredient in Malay herbal medicine for intermittent fever (malaria) (Gimlette and Thomson, 1977;Perry and Metzger, 1980).The plant contains a series of quassinoids, which are mainly responsible for its bitter taste and some have been reported as active against the in vitro culture of malarial parasites, Plasmodium falciparum (Chan et al, 1986(Chan et al, , 1989Kardono et al, 1991;Phillipson and Wright, 1991;Ang et al, 1995;Jiwajinda et al, 2002). The present work investigated further the antiplasmodial activity of these quassinoids, eurycomanone (1), 14,15␤-dihydroxyklaineanone (2), eurycomanol (5) and eurycomalactone (6), together with the others, 13,21-dihydroeurycomanone (3), 13␣(21)-epoxyeurycomanone (4) and an alkaloid, 9-methoxycanthin-6-one (7) from this plant, their activity not previously described, following the method of Plasmodium falciparum lactate dehydrogenase assay (Makler and Hinrichs, 1993; against the chloroquine-resistant Gombak A isolate and chloroquine-sensitive D10 strain (Fig.…”