A Química Na Avaliação Do Impacto À Saúde Humana Diante Da Exposição Aos Pesticidas

Abstract

THE CHEMISTRY IN THE HUMAN HEALTH RISK ASSESSMENT DUE PESTICIDES EXPOSURE. Pesticides are widely used worldwide in urban and rural environments. Since most pesticides are not selective for target species the concern about possible impacts on human health has increased for the workers exposed to these substances (occupational exposure) and for the general population (environmental exposure). Epidemiological studies, in vivo and in vitro have associated several diseases with pesticide exposure, such as cancer, diabetes, Parkinson’s, and others. Therefore, chemistry plays an important role in evaluation of external (food and drinking water) and internal (human biomonitoring) exposure to pesticides through of analytical methodologies, for instance, chromatography coupled with mass spectrometry, proving to be an important complement in the evaluation of risks of pesticides in human health.

Análise dos principais impactos ambientais na Serra Gravatá, Município de Jardim, Ceará

“…Vale ressaltar, que existe também uma forma bastante prejudicial de tratar a lavoura, que é através da utilização de fertilizantes, pesticidas, herbicidas e inseticidas no controle de pragas (Medeiros et al, 2021). Com isso os principais problemas relacionados aos solos são: perda do solo em alguns locais, áreas inutilizadas, a redução da fertilidade do solo, compactação do solo, degradação da paisagem, deslizamentos e a perda da fauna.…”

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

“…Human exposure to these compounds occurs acutely or chronically and can occur through the skin, respiratory and oral routes, food, water, or accidental ingestion (Table 4) (2,6,152). In addition, people may be in direct contact with pesticides during the preparation and use of pesticides and/or indirectly through breathing residual concentrations in the air or found on surfaces, food, and dust (100).…”

“…Pesticide-induced effects have been the subject of many published in vitro and in vivo studies aimed at expanding the scientific basis of current risk assessment procedures by allowing a better understanding of the mechanism of chemical-induced toxicity and its safety levels. These experimental studies show that pesticides alter DNA, leading to mutations and chromosomal aberrations that lead to the development of cancers and other diseases (2). The articles in our search that address in vitro and in vivo studies used for this review are listed in Tables 5, 6.…”

“…Most of them are considered persistent organic pollutants that can accumulate in the ecosystem and remain in the environment for considerable periods due to their lipophilic characteristic and long half-life (1)(2)(3).…”

Discussion about the new legal framework for agrotoxics in Rio Grande do Sul

“…No momento atual, inúmeros estudos analisam a relação entre a contaminação por agrotóxicos com diversos tipos de câncer, problemas psiquiátricos, suicídio e outras patologias que podem acometer o indivíduo humano. Medeiros et al (2021) No terceiro momento do desenvolvimento do estudo foi realizada uma revisão sistemática através da pesquisa em plataformas digitais de pesquisa acadêmica por meio da utilização de algumas combinações de palavras em português e inglês. Entre as palavras-chave utilizadas nas combinações estão: agrotóxico, saúde humana, danos 2002).…”