1981
DOI: 10.1080/01971528108062989
|View full text |Cite
|
Sign up to set email alerts
|

A Radioimmunoassay to Measure Cyclosporin a in Plasma and Serum Samples

Abstract: A radioimmunoassay for the immunosuppressant drug Cyclosporin A has been developed which makes possible the monitoring of the drug by direct measurements in clinical plasma and serum samples. The antisera have been produced in rabbits using the hemisuccinate derivative of a structural analogue of Cyclosporin A as a hapten. The assay has both adequate specificity and sensitivity for Cyclosporin A to be suitable for the routine monitoring of therapy. Some degree of cross-reactivity has been shown to occur with f… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
38
0
1

Year Published

1984
1984
1990
1990

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 268 publications
(39 citation statements)
references
References 6 publications
0
38
0
1
Order By: Relevance
“…measurements has been reported previously (Donatsch et al, 1981;Carruthers et al, 1983;Kennedy et al, 1984). Based on RIA studies with serum, Donatsch et al (1981) attributed this to the cross reactivity of metabolite 17 with the cyclosporin antibody.…”
Section: Discussionmentioning
confidence: 70%
See 3 more Smart Citations
“…measurements has been reported previously (Donatsch et al, 1981;Carruthers et al, 1983;Kennedy et al, 1984). Based on RIA studies with serum, Donatsch et al (1981) attributed this to the cross reactivity of metabolite 17 with the cyclosporin antibody.…”
Section: Discussionmentioning
confidence: 70%
“…Based on RIA studies with serum, Donatsch et al (1981) attributed this to the cross reactivity of metabolite 17 with the cyclosporin antibody. However, since we found essentially no metabolite 17 or 18 in serum, the differences between RIA and h.p.l.c.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Initially, CsA analysis was based on radioimmunoassay (r.i.a. ), which uses a rabbit polyclonal antibody, which cross-reacts to a large extent with metabolites of CsA (Donatsch et al, 1981;Robinson et al, 1983). Some of the metabolites may have weak immunosuppressive properties, while others appear to be inactive (Freed et al, 1987;Hartman & Jardine, 1987;Hartman et al, 1985;Maurer, 1985).…”
Section: Introductionmentioning
confidence: 99%