A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer

Wong, Kee H.; Kuciejewska, Aleksandra; Sharabiani, Mansour Taghavi Azar; Ng-Cheng-Hin, B.; Hoy, Sonja; Hurley, Tara; Rydon, Joanna; Grove, Lorna; Santos, Antônio Cardozo dos; Ryugenji, Motoko; Bhide, Shreerang A.; Nutting, Chris; Harrington, Kevin; Newbold, Kate

doi:10.1016/j.radonc.2016.06.015

Cited by 31 publications

(47 citation statements)

References 18 publications

(20 reference statements)

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“…In all studies, the oncologic treatment method is described: chemotherapy [2], combined chemotherapy and radiotherapy [3,10,11], radiotherapy [11], chemotherapy [12,13,14], combined chemotherapy and radiotherapy [15,16], radiotherapy [17,18], combined chemotherapy and radiotherapy [18], chemotherapy [19], combined chemotherapy and radiotherapy [20], radiotherapy [20], chemotherapy [21], combined chemotherapy and radiotherapy [22,23], radiotherapy [24], combined chemotherapy and radiotherapy [25], radiotherapy [26], combined chemotherapy and radiotherapy [27], chemotherapy [28]. …”

Section: Methodsmentioning

confidence: 99%

Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

et al. 2019

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Background and objectives: Oral mucositis is one of the main adverse events of cancer treatment with chemotherapy or radiation therapy. It presents as erythema, atrophy or/and ulceration of oral mucosa. It occurs in almost all patients, who receive radiation therapy of the head and neck area and from 20% to 80% of patients who receive chemotherapy. There are few clinical trials in the literature proving any kind of treatment or prevention methods to be effective. Therefore, the aim of this study is to perform systematic review of literature and examine the most effective treatment and prevention methods for chemotherapy or/and radiotherapy induced oral mucositis. Materials and methods: Clinical human trials, published from 1 January 2007 to 31 December 2017 in English, were included in this systematic review of literature. Preferred reporting items for systematic reviews and meta-analysis (PRISMA) protocol was followed while planning, providing objectives, selecting studies and analyzing data for this systematic review. “MEDLINE” and “PubMed Central” databases were used to search eligible clinical trials. Clinical trials researching medication, oral hygiene, cryotherapy or laser therapy efficiency in treatment or/and prevention of oral mucositis were included in this systematic review. Results: Results of the studies used in this systematic review of literature showed that laser therapy, cryotherapy, professional oral hygiene, antimicrobial agents, Royal jelly, L. brevis lozenges, Zync supplementation and Benzydamine are the best treatment or/and prevention methods for oral mucositis. Conclusions: Palifermin, Chlorhexidine, Smecta, Actovegin, Kangfuxin, L. brevis lozenges, Royal jelly, Zync supplement, Benzydamine, cryotherapy, laser therapy and professional oral hygiene may be used in oral mucositis treatment and prevention.

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Section: Methodsmentioning

confidence: 99%

Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

et al. 2019

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“…A search for recently published articles about SCPR identified a large RCT, which concluded that SCPR was ineffective in the management of OM in H&N cancer patients treated with RT/RT-CT [83]. A recent RCT in pediatric patients [84] and comparative studies about SCPR indicated conflicting results about the effectiveness in preventing OM [23,85].…”

Section: Discussionmentioning

confidence: 99%

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Yarom

Hovan²,

Bossi

et al. 2019

Support Care Cancer

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Purpose To update the clinical practice guidelines for the use of natural and miscellaneous agents for the prevention and/or treatment of oral mucositis (OM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible. Results A total of 78 papers were identified within the scope of this section, out of which 29 were included in this part, and were analyzed with 27 previously reviewed studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. The previous Recommendation against the use of parenteral glutamine for the prevention of OM in hematopoietic stem cell transplantation (HSCT) patients was reestablished. A previous Suggestion for zinc to prevent OM in H&N cancer patients treated with radiotherapy or chemoradiotherapy was reversed to No Guideline Possible. No guideline was possible for other interventions. Conclusions Of the vitamins, minerals, and nutritional supplements studied for the management of OM, the evidence supports a Recommendation against parenteral glutamine in HSCT patients and a Suggestion in favor of oral glutamine in H&N cancer patients for the management of OM.

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“…Benzydamine (a locally acting topical nonsteroidal anti‐inflammatory) was also demonstrated to decrease OM when compared to saline mouth wash daily during RT with the greatest effect in reducing oral pain . Caphasol, which is marketed to lubricate the mouth for xerostomia, did not result in any decrease in mucositis when provided during RT . Finally, in a single dose study, the use of doxepin (a tricyclic antidepressant) or “Magic Mouth Wash” (lidocaine‐containing rinse) each compared to placebo noted decreased oral pain in the first 60 minutes with either experimental agent, whereas those receiving doxepin had increased fatigue compared to placebo …”

Section: Discussionmentioning

confidence: 99%

“…42 Caphasol, which is marketed to lubricate the mouth for xerostomia, did not result in any decrease in mucositis when provided during RT. 43 Finally, in a single dose study, the use of doxepin (a tricyclic antidepressant) or "Magic Mouth Wash" (lidocaine-containing rinse) each compared to placebo noted decreased oral pain in the first 60 minutes with either experimental agent, whereas those receiving doxepin had increased fatigue compared to placebo. 44 Taken together, the results reported here are suggestive of a protective effect of D-met in preventing OM.…”

Section: Discussionmentioning

confidence: 99%

Double‐blind placebo‐controlled multicenter phase II trial to evaluate D‐methionine in preventing/reducing oral mucositis induced by radiation and chemotherapy for head and neck cancer

et al. 2018

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A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer

Abstract: Caphosol did not reduce the incidence or duration of severe OM during and after radiotherapy in HNC.

Cited by 31 publications

References 18 publications

Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Double‐blind placebo‐controlled multicenter phase II trial to evaluate D‐methionine in preventing/reducing oral mucositis induced by radiation and chemotherapy for head and neck cancer

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