A randomised trial of 5% minoxidil versus combination of 5% minoxidil and oral spironolactone in treatment of female pattern hair loss

Palaskar, Nachiket; Chaudhari, Nitin D; Balpande, Garima Laxminarayan; Khatu, Swapna S

doi:10.18203/issn.2455-4529.intjresdermatol20194565

Cited by 1 publication

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“…The recommended first-line treatment for many of patients with FPHL is 5% minoxidil solution/foam. 19 Minoxidil is a peripheral vasodilator drug; it relaxes vascular smooth muscles directly lowering systolic and diastolic blood pressure. This action is due to the activation of calcium channels.…”

Section: Discussionmentioning

confidence: 99%

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Treatment with oral vitamin D alone, topical minoxidil, or combination of both in patients with female pattern hair loss: A comparative clinical and dermoscopic study

Hassan

Sadoma

Elbatsh

et al. 2022

J of Cosmetic Dermatology

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Background One of the most common dermatological complaints among female is female pattern hair loss (FPHL). Serum vitamin D is a factor lately taken into consideration in approaching patients complaining of hair loss. Aim To evaluate the serum level of 25‐hydroxy vitamin D in patients with FPHL and to evaluate the efficacy of vitamin D therapy alone or combined with minoxidil in the treatment of this disease. Methods 45 patients with FPHL and 15 controls to measure serum level of vitamin D were enrolled in the study. Patients then were subdivided into 3 groups: group I received topical minoxidil and oral vitamin D, group II received topical minoxidil, and group III received oral vitamin D for 6 months. Clinical and dermoscopic evaluation was done for the three groups before and after treatment. Results Vitamin D level was significantly decreased in patients compared to controls. After treatment, as regard Ludwig scale, there was statistically significant improvement in group I than II while no significant improvement was found in group III. Dermoscopy revealed that thin hair and single‐hair unit were significantly improved in groups I and II, while it was not significantly improved in group III. Conclusion Oral vitamin D combination to topical minoxidil is recommended to treat patients with FPHL; they had better results than vitamin D or topical minoxidil alone.

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Section: Discussionmentioning

confidence: 99%

“…It is theorized that minoxidil may prolong the anagen phase of hair follicles, shorten the telogen phase, induce enlargement of miniaturized follicles, thereby contributing to the conversion of miniaturized hairs to terminal hair. The recommended first‐line treatment for many of patients with FPHL is 5% minoxidil solution/foam 19 …”

Section: Discussionmentioning

confidence: 99%